A5101653297- Chronic Kidney Disease and Diabetes
- Cancer Immunotherapy and Biomarkers
- Dialysis and Renal Disease Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Renal and related cancers
- Thermoregulation and physiological responses
- Renal cell carcinoma treatment
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Urological Disorders and Treatments
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Vascular Procedures and Complications
- Blood Coagulation and Thrombosis Mechanisms
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Potassium and Related Disorders
- Vascular anomalies and interventions
- Parvovirus B19 Infection Studies
- Advanced MRI Techniques and Applications
Tohoku Medical and Pharmaceutical University
2022-2025
Tohoku Medical and Pharmaceutical University Hospital
2022-2025
Nagoya University
2025
Gunma University
2024
Tohoku University
1967-2023
Toyohashi Municipal Hospital
2023
Osaka University
1984-2023
Konan Kosei Hospital
2020-2022
Toyota Memorial Hospital
2021
Oita University Hospital
2020
Nephrolithiasis is a common renal disease with no effective medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have diuretic and anti-inflammatory properties could prevent nephrolithiasis. Here, we investigated the potential of SGLT2 inhibition against nephrolithiasis using large-scale epidemiological data, animal models, cell culture experiments. This study included data diabetic patients (n = 1,538,198) available in Japanese administrative database...
The aortic regurgitant fraction was estimated noninvasively in 20 patients with regurgitation from systolic and pulmonary volume flow determined by duplex Doppler echocardiography. By assuming that an excess of the (AF) compared (PF) is due to flow, (RF) calculated as follows: RF(%) = (AF - PF)/AF X 100. flows were products integrals ejection velocities cross-sectional areas left right ventricular outflow tracts, respectively. estimate semiquantitative grading (1+ 4+) cineaortography...
The aim of this study was to assess the utility neutrophil-to-lymphocyte ratio (NLR), plate-let-to-lymphocyte (PLR), and systemic immune inflammation index (SII) as predictive biomarkers with oncological outcomes for metastatic renal cell carcinoma (mRCC) patients treated nivolumab ipilimumab (NIVO + IPI). We conducted a retrospective multicenter cohort assessing mRCC NIVO IPI at eight institutions in Japan. In study, follow-up period median 14 months. 1-year overall- progression-free...
Temozolomide (TMZ, 3,4-dihydro-3-methyl-4-oxoimidazo [5,1-d]-as-tetrazine-8-carboxamide) is a new alkylating agent with promising antitumour efficacy for malignant gliomas. The resistance of tumour cells to TMZ primarily associated levels the alkylguanine alkyltransferase (AGT). O6-benzylguanine (O6-BG), an inhibitor AGT, reduced TMZ. Recently, it has been demonstrated that chemosensitivity related decline in telomerase activity. However, unknown if sensitivity glioma correlates telomerase....
Abstract Renal congestion is an issue of cardiorenal syndrome in patients with heart failure. Recent clinical and basic studies suggest a renoprotective potential sodium–glucose cotransporter (SGLT) 2 inhibitors. However, the effect on renal its mechanism not fully understood. Thus, we aimed to clarify SGLT inhibition model. was induced left kidney male Sprague-Dawley rats by ligation inferior vena cava between veins. The SGLT2 inhibitor tofogliflozin or vehicle orally administered daily...
We investigated the temperature changes and their distribution in agar phantoms dog normal brains induced by 8 MHz radiofrequency interstitial hyperthermia observed histological changes, with respect to neurons myelinated nerve fibres, same heat source brains. also examined change of blood-brain barrier permeability using Evans blue solution. The heating limits brain were 42 degrees C for 45 min or 43 15 breakdown BBB was at 60 min.
Journal Article Accepted manuscript Serosal nodules and orange peritoneal dialysis effluent Get access Hiroki Ito, Ito Division of Nephrology Endocrinology, Faculty Medicine, Tohoku Medical Pharmaceutical University, Sendai, Miyagi, Japan Corresponding author: MD, PhD, 1-15-1, Fukumuro, Miyagino, 983-8536, Japan. Tel: +81–22–290–8850, Fax: +81–22–290–8860, email: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Kentaro Yano, Yano Takefumi Mori...
Purpose Spinal metastases are common and affect most patients with metastatic cancer. Surgery is crucial for managing symptoms such as pain paralysis but carries a high risk of complications, especially in the elderly. This study aimed to investigate impact short versus long fixation on outcomes mainly focused surgery-related complications elderly ≥60 years old undergoing surgery single-level spinal metastasis. Methods retrospective multicenter cohort study. We retrospectively analyzed data...