A5101623511- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Hippo pathway signaling and YAP/TAZ
- Angiogenesis and VEGF in Cancer
- Acute Lymphoblastic Leukemia research
- Seaweed-derived Bioactive Compounds
- Infectious Diseases and Mycology
- Artificial Intelligence in Healthcare
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Microscopic Colitis
- Mosquito-borne diseases and control
- Reproductive System and Pregnancy
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Echinoderm biology and ecology
- Nail Diseases and Treatments
- SARS-CoV-2 detection and testing
- Impact of AI and Big Data on Business and Society
- Protein Hydrolysis and Bioactive Peptides
- Cerebral Palsy and Movement Disorders
- Kruppel-like factors research
- Tuberculosis Research and Epidemiology
The University of Texas MD Anderson Cancer Center
2024
Adamas University
2022-2023
Houston Methodist
2020-2023
University College of Medical Sciences
2019
National Institute of Immunology
2017
Govind Ballabh Pant Hospital
2013
University of Waterloo
2009
Artificial intelligence (AI) is a branch of computer science that allows machines to work efficiently, can analyze complex data. The research focused on AI has increased tremendously, and its role in healthcare service emerging at greater pace. This review elaborates the opportunities challenges pharmaceutical research. literature was collected from domains such as PubMed, Science Direct Google scholar using specific keywords phrases ‘Artificial intelligence’, ‘Pharmaceutical research’,...
In the last few years there has been an increasing incidence of infection due to non-neoformans Cryptococcus spp. especially in immunocompromised host. laurentii is a which rarely known cause bacteremia and pulmonary humans. Here we report case fungemia laurentii.
To study the involvement of specific Wnt(s) ligand during trophoblastic BeWo cell differentiation.BeWo cells on treatment with forskolin/human chorionic gonadotropin (hCG) were studied for fusion by desmoplakin I+II staining and/or hCG secretion ELISA. Levels Wnt10b/β-catenin/glial missing a (GCMa)/syncytin-1 qPCR/Western blotting in forskolin-/hCG-treated control siRNA and Wnt10b silenced cells.BeWo (5 IU/mL) led to 94-fold increase transcript. silencing showed significant decrease...
The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities the immunosuppressive microenvironment. We have explored possibility that drivers might be responsible for immune cell dysregulation shapes protumor performed a transcriptome analysis coding non-coding RNAs (ncRNAs) during in Rag2−/−γc−/− MEC1-based xenotransplantation model. DLEU2/miR-16 locus was found downmodulated monocytes/macrophages leukemic mice. To validate role this cluster tumor...
Previously, we reported that post-translational modifications (PTMs) of MAGI1, including S741 phosphorylation and K931 de-SUMOylation, both which are regulated by p90RSK activation, lead to endothelial cell (EC) activation. However, roles for MAGI1-PTMs in regulating EC permeability remain unclear despite MAGI1 being a junctional molecule. Here, show thrombin (Thb)-induced permeability, detected the electric cell-substrate impedance sensing (ECIS) based system, was decreased overexpression...
Background The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implicated D-flow-induced endothelial-to-mesenchymal transition (endoMT), but precise counteracting this process remains unclear. Method We developed phospho-specific S344 antibody generated knock-in...
The ProFitter 3-D Cross Trainer is a labile surface device used in the clinic and claimed to train spine stability. purpose of this study was quantify mechanics (compression shear forces stability), together with muscle activation (surface electromyography) torso hip, during three exercises. Trunk activity relatively low while exercising on (<25%MVC). Gluteus medius phasic horizontal sliding position, especially for an experienced participant. Sufficient spinal stability achieved all...
<p>Supplementary Figures S1-S17</p>
<div>Abstract<p>Chronic lymphocytic leukemia (CLL) is a B-cell neoplasia characterized by protumor immune dysregulation involving nonmalignant cells of the microenvironment, including T lymphocytes and tumor-associated myeloid cells. Although therapeutic agents have improved treatment options for CLL, many patients still fail to respond. Some also show immunosuppression. We investigated trabectedin, marine-derived compound with cytotoxic activity on macrophages in solid tumors....
Clostridioides difficile, previously known as Clostridium has been recognized an emerging nosocomial pathogen in recent years.Among hospitalized patients, it's a leading cause of increased mortality and morbidity.Earlier C. difficile infection (CDI) was not for high morbidity prolonged hospital stay.But, last few decades due to uncontrolled usage antibiotic immunosuppressive drugs, CDI frequency severity.Besides nonmodifiable risk factors, exposure antibiotics is single most modifiable...
Aims: To investigate the role of Checkpoint Kinase 1 (CHK1)-associated SENP2 S344 phosphorylation in laminar flow (LF)-regulated Endothelial-Mesenchymal Transition (EndMT) inhibition and underlying mechanisms. Methods: We generated deSUMOylation enzyme sentrin-specific isopeptidase 2 (SENP2) S343A (equivalent to human S344) knock-in (KI) endothelial cell (EC)-specific knock-out (SENP2 EKO) mice detect EC activation, EndMT, atherogenesis vitro vivo . also performed next-generation RNA...