A5102003754- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Diabetes Treatment and Management
- Cervical Cancer and HPV Research
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Renin-Angiotensin System Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition, Genetics, and Disease
- Hemophilia Treatment and Research
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Synthesis and biological activity
- Curcumin's Biomedical Applications
- Cancer-related Molecular Pathways
- Atherosclerosis and Cardiovascular Diseases
Era's Lucknow Medical College and Hospital
2016-2025
King George's Medical University
2007-2022
Pir Mehr Ali Shah Arid Agriculture University
2021-2022
University of Tennessee Health Science Center
2022
Hunter Holmes McGuire VA Medical Center
2010
Virginia Commonwealth University
2010
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global health issue and develops into broad range of illnesses from asymptomatic to fatal diseases. SARS-CoV-2 is associated with oxidative stress that triggers cytokine production, inflammation, other pathophysiological processes. Glutathione-S-transferase (GST) an important enzyme catalyzes the conjugation glutathione (GSH) electrophiles protect cell damage...
Cancer progression is linked to abnormal epigenetic alterations such as DNA methylation and histone modifications. Since alterations, unlike genetic changes, are heritable reversible, they have been considered interesting targets for cancer prevention therapy by dietary compounds luteolin. In this study, modulatory behaviour of luteolin was analysed on HeLa cells. Various assays including colony forming migration assays, followed biochemical enzymes methyltransferase, methyl transferase,...
Abstract Background Coronavirus disease 2019 (COVID-19) is an ongoing pandemic which has emerged as a new challenge for the medical sciences. Severity of COVID-19 mostly determined with overexpressed proinflammatory cytokines eventually leading to endothelial dysfunction causing vital organ injury, especially in lungs. It been postulated that various genetic mutations might be associated increased risk severity COVID-19. This study was thus carried out determine association rs1800896 and...
Coronavirus disease-2019 (COVID-19) is pro-inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin-6, a cytokine secreted macrophages, which mediates an inflammatory response, frequently increased and associated with the severity in COVID-19 patients. The differential expression of IL6 patients may be presence single nucleotide polymorphisms (SNPs) regulatory region genes. aim this study to investigate role two promoter gene (-597G > A -174G C) COVID-19....
Background: Hypertension has a multi-factorial background based on genetic and environmental interactive factors. ACE, FABP2 GST genes have been suggested to be involved in the development of hypertension. However, results inconsistent.Aim: The present study was carried out investigate association ACE (rs4646994), (rs1799883) (GSTM1 null or positive genotype GSTT1 genotype) polymorphism with essential HTN cases controls.Subjects methods: This includes 138 hypertension (HTN) patients 116...
Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels blood sugar associated with long-term damage, organs failure, especially the eyes, heart, kidneys, vessels and nerves whose frequency has increased progressively worldwide. The aims this study were evaluate plasma miRNA-126, miRNA-486, miRNA-223 miRNA-375 newly diagnosed T2DM susceptible healthy control individuals. In study, we...
Diabetic dyslipidemia is one of the leading causes coronary artery disease (CAD) death. Genetic and environmental factors play an important role in development type 2 diabetes mellitus (T2DM) dyslipidemia. The present study was aimed to investigate association ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) FTO (rs9939609) genes polymorphism T2DM with Totally, 559 subjects including 221 cases dyslipidemia, 158 without 180 controls were enrolled. evaluated by polymerase chain reaction...
Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world with expected doubling of incidence to millions affected individuals last decades. At present, adequate data are not available regarding ACE and FABP2 polymorphisms their susceptibility T2DM cases North Indian population. Thus we conceived need for further study (I/D) (Ala54Thr) genes polymorphism its population.In this study, a total 300 subjects (including 190 110 controls) participated. gene controls were...