Koji Kitaoka
A5087594683- Cancer Immunotherapy and Biomarkers
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Protein Hydrolysis and Bioactive Peptides
- Immune cells in cancer
- Immunotherapy and Immune Responses
Kyoto University
2022-2024
Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors aged mice by increasing mitochondrial function and activating CD8+ T cells. Treatment of naïve cells with acutely enhanced fatty acid oxidation. conjugated to beads bound trifunctional protein (MTP). In MTP complex, synthesized purified from Escherichia coli, α β subunits strong affinity allosterically their enzymatic activities. cell-specific deletion...
<title>Abstract</title> Glycolysis and mitochondrial fatty acid oxidation (FAO) regulate CD8+ T cell differentiation fate. However, how glycolysis FAO balance are associated with T-cell exhaustion remains unknown. PD-1 signal inhibits enhances FAO. We find that cells in the tumors adhered to attenuated despite high expression, which was defined as “metabolic exhaustion.” Active aldehydes, final products of lipid peroxidation, accumulate proportion their depth mouse human tumor tissues....