A5101778472- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and biological activities of Ficus species
- Ginger and Zingiberaceae research
- Berberine and alkaloids research
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Quantum optics and atomic interactions
- Medicinal Plant Pharmacodynamics Research
- Natural Antidiabetic Agents Studies
- Atomic and Subatomic Physics Research
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Drilling and Well Engineering
- Hydraulic Fracturing and Reservoir Analysis
- Psychosomatic Disorders and Their Treatments
- Flavonoids in Medical Research
- Mangiferin and Mango Extracts
- Freezing and Crystallization Processes
- Optical Polarization and Ellipsometry
- Pain Management and Placebo Effect
- Glycosylation and Glycoproteins Research
- Plant and Fungal Species Descriptions
- Curcumin's Biomedical Applications
- Medicinal Plants and Bioactive Compounds
Harbin Institute of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2023
Peking Union Medical College Hospital
2009-2023
Northeast Forestry University
2019
Harbin University
2019
Academy of Medical Sciences
2009-2018
Texas Tech University
2009
The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). present study investigated the neuroprotective potential quercetin, natural AMPK activator. Streptozotocin (STZ)-induced rats that developed DPN phenotype were orally administrated with quercetin (30 and 60 mg/kg per day) for 6 weeks. morphologic changes sciatic nerves (SN), pathological structure neurons dorsal root ganglion (DRG),...
OBJECTIVE This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi [SZ-A]) in treatment type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS was a multicenter, randomized, double-blind, double-dummy, parallel controlled noninferiority clinical trial that conducted for 24 weeks. A total 600 patients were randomly allocated SZ-A group (n = 360) or acarbose 240). The primary end point change glycosylated hemoglobin (HbA1c) compared with baseline. In addition,...
To investigate the association between serum adiponectin levels and diabetic peripheral neuropathy (DPN) in Chinese type 2 diabetes (T2D) patients. Two hundred nineteen T2D patients aged 40-79 years were divided into two groups according to whether they had DPN. The systemic of five biomarkers measured using a human adipokine multiplexed bead-based immunoassay. Diabetic diagnostic criteria included both common DPN symptoms neurological screening tests. Most features (n=98) non-DPN (n=121)...
To investigate the neuroprotective effect of puerarin on rat hippocampal neurons cultured in high glucose medium, and to examine role p38 mitogen activated protein kinase (p38 MAPK) c-Jun N-terminal (JNK) signaling pathways this effect. Primary cultures were prepared from newborn Sprague Dawley rats. Neuron-specific enolase immunocytochemistry was used identify neurons. The with normal medium (control group) or high-glucose (high-glucose group), (puerarin a MAPK inhibitor (SB239063; JNK...
<italic>tert</italic>-Butyloxycarbonyl (TBOC) substituted quinacridone (QA) derivative TBOC-QA was synthesized <italic>via</italic> a one-step simple chemical reaction and showed intense emission in both solution the solid state.
To observe the effects of Bushen Huoxue Formula (Formula for reinforcing kidney and activating blood circulation) on learning memory function cerebral neurotransmitters in diabetic mice. Forty ICR mice were randomized into normal control group, model Nimotop group Chinese medicine 10 each group. Tail intravenous injection alloxan was applied to prepare model. Four weeks later, intragastric administration isometric distilled water other two groups respectively given 8 weeks. The changes sugar...
To investigate effect of icariin on apoptosis in hippocampal neurons cultured high glucose, and the possible mechanism behind action.Hippocampus was obtained from newborn 24 h Sprague-Dawley rats then primarily cultured. Then were divided into normal control group, glucose + protein kinase B (Akt) inhibitor group Akt agonist group. After each different conditioned medium for 72 h, we detected with flow cytometry, expression Akt, p-Akt, B-cell lymphoma-2 (Bcl-2) Bcl-2 associated X (Bax)...