A5102985168- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin C and Antioxidants Research
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
University of Michigan
2021-2022
Abstract Objective The intersection between immunology and metabolism contributes to the pathogenesis of obesity‐associated metabolic diseases as well molecular control inflammatory responses. metabolite itaconate cell‐permeable derivatives have robust anti‐inflammatory effects; therefore, it is hypothesized that cis‐aconitate decarboxylase (Acod1)‐produced has a protective, effect during diet‐induced obesity disease. Methods Wild‐type Acod1 −/− mice were subjected obesity. Glucose was...
Abstract Objective Excess dietary fat and sodium (NaCl) are both associated with obesity metabolic dysfunction. In mice, high NaCl has been shown to block high‐fat (HF) diet–induced weight gain. Here, the impact of an HF/NaCl diet on function in absence was investigated. Methods Wild‐type mice were administered chow, (4%), HF, diets. Metabolic analysis performed by measuring fasted blood glucose insulin levels tolerance test test. Results After 10 weeks diets, male female HF gained weight,...