A5017132629- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Autopsy Techniques and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury Research
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Traffic and Road Safety
- Cerebrovascular and genetic disorders
- Pharmacological Effects and Toxicity Studies
- Forensic Anthropology and Bioarchaeology Studies
- Injury Epidemiology and Prevention
- Esophageal and GI Pathology
- Forensic Entomology and Diptera Studies
- Trauma and Emergency Care Studies
- Peripheral Neuropathies and Disorders
- Lysosomal Storage Disorders Research
- Restless Legs Syndrome Research
Institute of Psychiatry and Neurology
2017-2025
Medical University of Warsaw
2016-2025
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity that may be caused by abnormal serotonergic signaling. Using combination of behavioral, biochemical, and imaging methods, we analyze 5-HT7R/MMP-9 signaling dendritic spine in the hippocampus mice treated with selective 5-HT7R agonist (LP-211) model chronic unpredictable stress (CUS)-induced depressive-like behavior. We show acute activation induces behavior an MMP-9-dependent manner post mortem brain...
The pathogenesis of neurovascular diseases and various types dementia is tightly connected to cerebral circulation. An area that requires further exploration the system deep perforating arteries-arteries branching directly from high-pressure intracranial arteries, supplying vital neural structures such as internal capsule, characterized by a diameter well below 1 mm, which makes them difficult visualize with standard radiological examinations. This study aimed analyze morphology perforator...
Coronavirus disease 2019 (COVID-19) poses a global challenge to healthcare and society in the early 21st century. We report neuropathological changes 52 patients aged between 22 years 88 (median 58 years) who were infected with CoV-2 coronavirus. Patients died under various circumstances had pre-existing diseases. The inclusion criteria for this study were: positive result nasopharyngeal swab SARS-CoV-2 RNA, diagnosis of pneumonia or nucleoproteins pulmonary tissue confirmed by...
Abstract Subacute sclerosing panencephalitis (SSPE) is a fatal, slowly progressive brain disorder caused by mutated measles virus. Both subacute inflammatory and neurodegenerative mechanisms appear to play significant roles in the pathogenesis. TAR DNA-binding protein 43 (TDP-43) inclusions are common co-pathology several disorders with diverse In present study, we examined brains of 16 autopsied SSPE patients for presence TDP-43 pathology possible associations tau pathology....
Despite advances in understanding various risk and prognostic factors, spontaneous intracerebral hemorrhage is connected to very high morbidity mortality, while the therapy mainly supportive. Understanding of pathophysiology initial hematoma expansion limited due insufficient clinical data lack a suitable animal model.We injected 40 anatomic specimens basal ganglia with contrast medium, scanned them micro-computed tomography scanner analyzed results radiological studies, direct histological...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated the onset of neurological and psychiatric symptoms during after phase illness. Inflammation hypoxia induced by SARS-CoV-2 affect brain regions essential for fine motor function, learning, memory, emotional responses. The mechanisms these central nervous system remain largely unknown. While looking causes deficits, we conducted a study on how affects neurogenesis. In this study, compared control group...
Introduction: Cerebrovascular diseases are a growing social and clinical problem, their pathogenesis is currently being thoroughly investigated. The intravascular anatomy of the cerebral circulation remains poorly understood, although an increasing number endovascular interventions conducted during course diagnosis treatment. purpose this study was to describe structures in vertebrobasilar system investigate hemodynamic consequences presence. Methods: Thirty anatomical specimens human brain...
Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis very small hearts. This study was carried out five French bulldog puppies all presenting with advanced four diagnosed pulmonary hypoplasia at autopsy. The body weight dogs ranged from 142 687 g lungs weighed 4.5 23.6 g. hearts vessels were filled barium contrast, micro-CT scans...
The release of brain-originated peptides such as tau protein (MAPT), S-100β, neurofilament light chain (NFL), and glial fibrillary acidic (GFAP) into the cerebrospinal fluid (CSF) has been positively correlated with head injuries in clinical basic research. In this study, we wanted to examine if selected CSF biomarkers (GFAP, NFL, myelin - MBP) injury may be useful post-mortem examination diagnosis forensic cases. study was carried out using cases sudden death (cardiopulmonary failure, no...
Introduction A substantial percentage of traffic crashes involve people under the influence ethyl alcohol. In such circumstances, we speak possible effect ethanol upon trauma outcomes. The present research aimed to assess state sobriety fatal pedestrian victims and correlation between level severity injuries. Research material method data was obtained from Warsaw Medical University's Department Forensic Medicine. analysis covered for period 2009–2013; it encompassed 158 hit by passenger...
Adult neurogenesis includes proliferation and differentiation of progenitor cells as well their migration maturation. In the adult human brain, two neurogenic regions, hippocampal dentate gyrus (DG) subventricular zone (SVZ) lateral ventricles, have been identified. gyrus, three types transcriptionally active in zone, four cells, including GFAP-positive neural stem (NSCs), differentiated.The aim study was to identify compare density between groups patients (7 men, 7 women, mean age 70 ±...
Introduction: The dominant cause of injuries in traffic crashes. A significant portion them affects victims under the influence ethyl alcohol. goal studies was to assess correlation between state sobriety and severity expressed by injury scales fatal pedestrian Research Material Method: data were obtained from Warsaw Medical University's Department Forensic Medicine. analysis covered for 2009–2013 included 200 hit passenger cars. assessment effect risk factors on terms such as Life Threat...
Background: Standard computed tomography (CT) images have earned a well-established position in neuroimaging. Despite that, CT is somehow limited by its resolution, which does not enable to distinctively visualise structures smaller than 300 μm diameter. Perforating arteries, most of measure 100–400 diameter, supply important subcortical (thalamus, basal ganglia, internal capsule). Consequently, pathologies affecting these vessels (e.g. lacunar strokes) can devastating clinical outcome. The...
Traumatic brain injury (TBI) is characterized by various micro- and macrostructural neuropathological changes which can be identified in the light microscope examination. The most common pathophenotype of TBI visualized postmortem assessment includes neuron with involvement all its structural regions followed progressive degeneration defined as traumatic axonal (TAI). This directly related disruption axolemmal cytoskeletal network architecture resulting breakdown, dissolution accumulation a...
AMA Wierzba-Bobrowicz T, Lewandowska E, Zaremba J, et al. Case reportFrontotemporal lobar degeneration with MAPT mutation in an Italian-Polish family. A case report. Folia Neuropathologica. 2014;52(4):457-466. doi:10.5114/fn.2014.47848. APA Wierzba-Bobrowicz, T., Lewandowska, E., Zaremba, J., Berdyński, M., Żekanowski, C., & Stępień, T. (2014). Neuropathologica, 52(4), 457-466. https://doi.org/10.5114/fn.2014.47848 Chicago Teresa, Eliza Jacek Mariusz Cezary Tomasz and Paulina Felczak 2014....