A5011038101- Zoonotic diseases and public health
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Brucella: diagnosis, epidemiology, treatment
- Vector-Borne Animal Diseases
- Primate Behavior and Ecology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Wildlife Ecology and Conservation
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Vector-borne infectious diseases
- Disaster Response and Management
- Parasitic Infections and Diagnostics
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Burkholderia infections and melioidosis
- Child Nutrition and Water Access
- Antibiotic Use and Resistance
- Parasite Biology and Host Interactions
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
Makerere University
2015-2025
Partners for Health and Development in Africa
2023
University of Minnesota
2014-2022
Collaborative Research Group
2022
Faculty of Public Health
2019-2020
Twin Cities Orthopedics
2020
Office of Readiness and Response
2019
Mbale Hospital
2019
Busitema University
2019
Kampala University
2017
Abstract: Habitat overlap can increase the risks of anthroponotic and zoonotic pathogen transmission between humans, livestock, wild apes. We collected Escherichia coli bacteria from mountain gorillas ( Gorilla gorilla beringei ) in Bwindi Impenetrable National Park, Uganda, May to August 2005 examine whether habitat influences rates patterns humans apes livestock might facilitate transmission. genotyped 496 E. isolates with repetitive extragenic palindromic polymerase chain reaction...
Abstract We conducted a prospective study of bacterial transmission among humans, nonhuman primates (primates hereafter), and livestock in western Uganda. Humans living near forest fragments harbored Escherichia coli bacteria that were ≈75% more similar to from those than nearby undisturbed forests. Genetic similarity between human/livestock primate increased ≈3-fold as anthropogenic disturbance within moderate high. Bacteria by humans approximately twice red-tailed guenons, which habitually...
Background Giardia duodenalis is prevalent in tropical settings where diverse opportunities exist for transmission between people and animals. We conducted a cross-sectional study of G. people, livestock, wild primates near Kibale National Park, Uganda, human-livestock-wildlife interaction high due to habitat disturbance. Our goal was infer the cross-species potential using molecular methods investigate clinical consequences infection. Methodology/Principal Findings Real-time PCR on DNA...
The last two decades has witnessed a disruption of socio-economic, security and political foundation worldwide due to surging health events arising at the ecosystem, animal human interface. unprecedent magnitude these led adoption One Health approach. Several theoretical definitions an operational one were released help common user understand To provide evidence impact implementing approach assess process outputs, definition intervention is required. We are proposing characteristics which...
ABSTRACT Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants. Here we isolated three novel bunyaviruses from mosquitoes sampled in Côte d'Ivoire, Ghana, Uganda. The viruses define a highly diversified monophyletic sister clade to all members genus Orthobunyavirus virtually equidistant orthobunyaviruses tospoviruses. Maximal amino acid identities between homologous putative proteins group ranged 12 25%. type isolates, tentatively named Herbert...
Background Cryptosporidium is one of the most common parasitic diarrheal agents in world and a known zoonosis. We studied people, livestock, non-human primates region Kibale National Park, Uganda. Land use change near park has resulted fragmented forest patches containing small, remnant populations wild that interact intensively with local people livestock. Our goal was to investigate risk factors for infection assess cross-species transmission using molecular methods. Methodology/Principal...
Brucellosis is one of the most common zoonotic infections globally. Lack knowledge about brucellosis may affect health-seeking behavior patients, thus leading to sustained transmission in these communities. Our study assessed and perceptions among pastoral communities adjacent Lake Mburo National Park (LMNP), Kiruhura District, Uganda. A community cross-sectional questionnaire survey involving 371 randomly selected household heads from three sub-counties neighboring LMNP were interviewed...
Nonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins human immunodeficiency viruses type 1 (HIV-1) and HIV-2. However, incomplete taxonomic geographic sampling potential hosts, especially African colobines, has left full range primate retrovirus diversity unexplored. Blood samples collected from 31 wild-living red colobus monkeys (Procolobus [Piliocolobus] rufomitratus tephrosceles)...
Most alphaviruses are transmitted by arthropods and infect vertebrate hosts. An exception is Eilat virus (EILV), the only described alphavirus with a host range restricted to insects. We established new generic reverse transcription PCR assay for tested 8860 tropical mosquitoes. detected novel alphavirus, tentatively named Taï Forest (TALV), in Culex decens mosquitoes collected Ivory Coast. The full genome was sequenced, closest similarity found EILV. Pairwise amino acid identities EILV...
Antibiotic resistance is a global problem. This study, conducted in rural western Uganda, describes antibiotic patterns Escherichia coli bacteria near two forested national parks. Resistance was present not only people, but also their livestock and nearby wild nonhuman primates. Multidrug class 1 integrons containing genes that confer were common similar people animals. The percentage of resistant isolates decreased with increasing local price the antibiotic. this setting likely reflects...
For conservation purposes and due to growing ecotourism, free-ranging mountain gorillas (Gorilla gorilla beringei) have been habituated humans. Fecal specimens (n = 62) collected in January 1999 from of the Bwindi Mgahinga National Parks, Uganda, were tested for Campylobacter spp., Salmonella Shigella overall prevalence infection was 19%, 13%, 6%, respectively. The positive not related year habituation a group Salmonella, spp. infections distributed equally among age classes gorillas; most...
In June 2005, we collected 115 fecal samples from wild primates in western Uganda and examined them for Cryptosporidium sp. Giardia with the use of immunofluorescent antibody (IFA) detection. We sampled an undisturbed forest Kibale National Park 3 highly disturbed fragments outside park. Of samples, red colobus (Pilocolobus tephrosceles) red-tailed guenons (Cercopithecus ascanius) harbored species or Giardia, but black-and-white (Colobus guereza) did not. All primate were negative both...
Escherichia coli is a zoonotic bacterium that important to both public health and livestock economics. To date, most studies of E. transmission have been conducted in developed nations with industrialized agricultural economies. In this study, bacteria were collected from people two communities rural western Uganda order investigate patterns interspecific bacterial developing economy characterized by very close human-livestock associations. Six hundred seventy-two isolates genotyped using...
Background Antimicrobial resistance is a worldwide public health emergency that requires urgent attention. Most of the effort to prevent this coming catastrophe occurring in high income countries and we do not know extent problem low middle-income countries, largely because laboratory capacity coupled with lack effective surveillance systems. We aimed at establishing magnitude antimicrobial among Escherichia coli Klebsiella pneumoniae carried gut out-patients from pastoralist communities...
Brucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. The disease can result permanent disabling sequelae considerable medical expenses addition to loss income due working hours. A case-control study was conducted Nyabushozi, Kiruhura district, Uganda, so as determine the risk factors for transmission brucellosis humans these communities.We matched among participants previous who were positive by standard Serum Agglutination Test with...
Brucellosis is a zoonotic disease of veterinary, public health, and economic significance in most developing countries, yet there are few studies that show integrated human veterinary health care intervention focusing on integration at both activity actors levels. The aim our study, therefore, was to explore community perceptions animal vaccination education by workers the management brucellosis Uganda.This study used qualitative design where six Focus Group Discussions (FGDs) were...
Bacillus anthracis, the bacteria that causes anthrax, a disease primarily affects herbivorous animals, is soil borne endospore-forming microbe. Environmental distribution of viable spores determines risky landscapes for herbivore exposure and subsequent anthrax outbreaks. Spore survival longevity depends on suitable conditions in its environment. Anthrax endemic Queen Elizabeth Protected Area western Uganda. Periodic historical outbreaks with significant wildlife losses date to 1950s, but B....
A workforce with the adequate field epidemiology knowledge, skills and abilities is foundation of a strong effective animal health system. Field training conducted in several countries to meet increased global demand for such workforce. However, core competencies veterinary have not been identified agreed upon globally, leading development different curricula. Having set can harmonize training. The Food Agriculture Organization United Nations (FAO) initiated collective, iterative,...
If not treated, gastrointestinal parasites (GIPs) can negatively affect dog fitness, performance, and growth cause severe sickness and/or death. Dogs harbour responsible for zoonosis, this is likely to be worst in contiguity conservation areas having many parasite reservoirs. To understand the GIPs status Bwindi, Mgahinga, Queen Elizabeth western Uganda, faecal samples (n = 284) collected from domestic dogs July 2022 were subjected parasitological analysis using sodium nitrate floatation...
Introduction Bats play critical roles not only in sustaining ecosystems but also human livelihoods across different scales. Despite such values, their populations continue to be threatened mainly by activities causing decline. Moreover, recent zoonotic diseases outbreaks have increased negative attitudes towards this taxon further threatening populations. This study sought contribute bat conservation programs providing scientific data on community willingness pay for within Mount Elgon...