A5080883732- Facial Trauma and Fracture Management
- Dental Radiography and Imaging
- Traumatic Ocular and Foreign Body Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthodontics and Dentofacial Orthopedics
- Oral and Maxillofacial Pathology
- Maternal and Perinatal Health Interventions
- Nursing Roles and Practices
- Head and Neck Surgical Oncology
- Dental Implant Techniques and Outcomes
- Facial Nerve Paralysis Treatment and Research
- Facial Rejuvenation and Surgery Techniques
- Pelvic and Acetabular Injuries
- Neurofibromatosis and Schwannoma Cases
- Phagocytosis and Immune Regulation
- Ocular Oncology and Treatments
- Surgical Simulation and Training
- Sinusitis and nasal conditions
- Calcium signaling and nucleotide metabolism
- IgG4-Related and Inflammatory Diseases
- Osteomyelitis and Bone Disorders Research
- Vascular Malformations Diagnosis and Treatment
- Delphi Technique in Research
- Gender, Labor, and Family Dynamics
- Trigeminal Neuralgia and Treatments
KU Leuven
2016-2025
Cliniques Universitaires Saint-Luc
2022-2023
UCLouvain
2022
Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)-mediated Ca2+-signaling. A peptide tool (Bcl-2/IP3R Disruptor-2; BIRD-2) was developed to abrogate the interaction of with IP3Rs targeting Bcl-2′s BH4 domain. BIRD-2 triggers cell death primary CLL cells DLBCL lines....
Abstract Background/aim Paediatric maxillozygomatic complex (MZC) fractures are uncommon, and there is a scarcity of data regarding their surgical treatment. The aim this study was to analyse choices outcomes open reduction internal fixation (ORIF) for MZC among 14 maxillofacial centers around the world. Materials Methods This multicentric retrospective observational included patients ≤16 years age with quadripod treated ORIF from January 2011 December 2022. following were collected: age,...
The training and preferences of surgeons influence the type surgical treatment for mandibular fractures. This multicentre prospective study analyzed current strategies outcomes fractures with open reduction internal fixation (ORIF).
Abstract This study aims to evaluate and compare the usability performance of mixed reality (MR) technology versus conventional methods for preoperative planning patient-specific reconstruction plates orbital fractures. A crossover design was used MR with three-dimensional (3D) printing approaches in maxillofacial traumatology treatments. The primary focus on user-friendliness accuracy planning. Secondary outcomes included investigating time differences between two evaluating potential...
Mandibular fractures are common maxillofacial injuries among children and adolescents, but treatment remains controversial. The aim of this study was to analyse the methods outcomes open reduction internal fixation (ORIF) for non-condylar mandibular in paediatric patients 14 centres. Patients ≤16 years age undergoing ORIF between 2011 2022 were included. Age, gender, dentition stage, site type fracture, surgical approach, material, thickness, number plates, outcome recorded. 179 (mean age,...
This study aims to quantify the facial symmetry of surgically treated zygomaticomaxillary complex (ZMC) fractures through a new reliable three-dimensional evaluation method, which is crucial for improving post-operative aesthetic and functional outcomes. Healthy patients with ZMC were retrospectively reviewed. Using Brainlab Elements® zygomatic bone orbit each patient was segmented mirrored. Subsequently, mirrored side matched other via volume-based registration, using as reference....
The aim of this 11-year retrospective multicentric study is to evaluate the policy 14 maxillofacial surgery divisions in terms titanium plate removal from paediatric patients who had undergone open reduction and internal fixation (ORIF) treat fractures. Patients ≤ 16 years undergoing surgical treatment for fractures middle lower third face between January 2011 December 2022, with a minimum follow-up 6 months, were included. Age (group A: years, B: 7–12 C: 13–16 years), sex, fracture location...
Background: Mandibular condyle fractures in pediatric patients can lead to crippling sequelae such as ankylosis, pain and facial deformity if not managed properly. However, there is no consensus on the best approach for treating these children. Objective: This study aimed describe management of mandibular growing across 14 maxillofacial departments worldwide. Methods: A retrospective multicenter was conducted children adolescents aged 0 16 who had at least one fracture. included underwent...
The best known café-au-lait syndrome is neurofibromatosis type 1 (NF1). Legius (LS) another, rarer with macules (CALMs). In young patients their clinical picture often indistinguishable. We investigated the presence of choroidal abnormalities in syndromes CALMs as a candidate tool for more efficient diagnosis. Thirty-four NF1 (14 truncating mutation, 14 non-truncating mutation and 6 unknown mutation) 11 LS. All underwent an ophthalmological examination. Infrared images were performed....
Retrospective study.Zygomaticomaxillary complex (ZMC) fractures are common facial injuries with heterogeneity regarding aetiologies, fracture types, infraorbital nerve (ION) involvement, and treatment methods. The aim of this study was to identify associations between neurological complications. Additionally, methods recovery time were investigated.Medical files 272 patients unilateral bilateral ZMC reviewed, whose cases managed from January 2014 2019 at the Department Oral Maxillofacial...
Trapdoor fractures of the orbital floor occur almost exclusively in paediatric population. Despite being widely discussed literature, their management remains controversial. The objective this retrospective study was to analyse surgical experiences on trapdoor maxillofacial centres participating WORMAT project. 14 collected data for patients aged ≤16 years operated between January 2011 and December 2022. demographic, cause type fracture, timing from injury surgery, approach, repair outcomes...
The treatment of mandibular condyle fractures remains a controversial topic in maxillofacial surgery. No uniform protocol is currently available.We performed retrospective monocentric cohort study patients with condylar and their treatment, including long-term follow-up by telephone, followed short review the literature.The available data on presenting at Leuven University Hospitals between January 1, 2009, December 31, 2015, were analyzed. Cause, age, sex, fracture level, degree...
Abstract Purpose Intraoperative stabilisation of bony fragments with maxillo‐mandibular fixation (MMF) is an essential step in the surgical treatment mandibular fractures that are treated open reduction and internal (ORIF). The MMF can be performed or without wire‐based methods, rigid manual MMF, respectively. aim this study was to compare use versus terms occlusal outcomes infective complications. Materials Methods This multi‐centric prospective involved 12 European maxillofacial centres...
Subperiosteal orbital abcess is a rarely reported complication of odontogenic infections and can be associated visual impairment neurological symptoms. Because fast infection spreading, delay in diagnosis treatment result permanent damage. A 55-year old presented with right-sided subperiosteal abscess originating from decayed first upper molar. The loss vision improved only after extraoral surgical drainage. Three years later, recurrent headaches, photobia ptosis still persist. Our case...
Recently, time-driven activity-based costing (TDABC) is put forward as an alternative, more accurate method to calculate the cost of a medical treatment because it allows assignment costs directly patients. The objective this paper application in order estimate childbirth at maternal department. Moreover, study shows how can be used outline vary according considered patient and disease characteristics. Through use process mapping, TDABC exactly identify which activities corresponding...
Cranial osteomyelitis is an uncommon, but important entity, particularly when misdiagnosed. This case report describes a 73-year-old woman with history of basal cell carcinoma in her right eyebrow. After treatment surgery and radiotherapy, two years later, she had undergone another operation for reconstruction orbital implants. The present study imaging aspects, options, follow-up incident that occurred seven after reconstruction. patient visited the emergency department, due to deep...
Objective: This study aims to quantify the facial symmetry of surgically treated zygomaticomaxillary complex (ZMC) fractures through a new reliable three-dimensional evaluation method, which is crucial for improving post-operative aesthetic and functional outcomes.Material methods: Healthy patients with ZMC were retrospectively reviewed. Using Brainlab Elements™ zygomatic bone orbit each patient was segmented mirrored. Subsequently, mirrored side matched other via volume-based registration,...
Abstract Background Recently, time-driven activity-based costing (TDABC) is put forward as an alternative, more accurate method to calculate the cost of a medical treatment because it allows assignment costs directly patients. The objective this paper demonstrate how overall childbirth at maternity department can be calculated by implementing TDABC analysis. In addition, study outlines utilized provide insights into patient and disease characteristics drive variability within cost. Through...