A5101531107- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Tattoo and Body Piercing Complications
- Cruise Tourism Development and Management
- China's Ethnic Minorities and Relations
- Oropharyngeal Anatomy and Pathologies
- Image and Object Detection Techniques
- Flavonoids in Medical Research
- Ureteral procedures and complications
- Sulfur Compounds in Biology
- Temporomandibular Joint Disorders
- Dental Anxiety and Anesthesia Techniques
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Kidney Stones and Urolithiasis Treatments
- Redox biology and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Quantum Mechanics and Non-Hermitian Physics
- Botulinum Toxin and Related Neurological Disorders
- Socioeconomic Development in Asia
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Shandong University of Traditional Chinese Medicine
2025
Guiyang Medical University
2022-2023
Guizhou University
2009-2023
Zunyi Medical University
2017-2023
Shanghai Jiao Tong University
2014-2022
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Zhejiang University of Technology
2022
Shanghai Chest Hospital
2022
Depression is characterized by oxidative stress in the brain. As crucial reductive biothiol, cysteine (Cys) directly regulates occurrence of Despite its significance, precise exploration Cys mouse brains remains a challenge, primarily owing to limitations Cys-monitoring tools, especially interference from unavoidable reaction with other biothiols. Thus, we developed novel two-photon fluorescence probe for based on new specific recognition site, thiobenzoate. Encountering Cys, carbon–sulfur...
Depression is associated with decreased expression of brain-derived neurotrophic factor (BDNF) which assembled in Golgi apparatus. The changes might be closely related to variation apparatus polarity. Thus, developing a nondestructive method detect polarity living cells and vivo can facilitate accurate diagnosis prognosis depression. Herein, we created new near-infrared Golgi-targetable fluorescent probe (Golgi-P) the merocyanine benzoyl difluoroboronate moieties sense changes. Golgi-P...
Background: Dendrobium nobile Lindl. alkaloids (DNLA) are effective in ameliorating cognitive deficit SAMP8, AβPP/PS1, and LPS-induced AD animal models, prevented Aβ-induced synaptic degeneration cultured hippocampal neurons. However, the underlying mechanisms remain unexplored. Objective: This study investigated protective effects of DNLA on damage an Aβ25-35-induced rat model, primary cortical neuron cultures, PC12 cells transfected with human AβPP695, focusing Wnt/β-catenin pathway....
Dendrobium nobile Lindl. alkaloids (DNLA), the active ingredients of a traditional Chinese medicine Dendrobium, have been shown to anti-oxidative effects, anti-inflammatory action, and protective effect on neurons against oxygen-glucose deprivation. However, it is not clear whether DNLA reduces amyloid-beta (Aβ)-induced neuronal injury. In this study, cortical were treated with at different concentrations (0.025, 0.25, 2.5 mg/L) for 24 hours, followed by administration Aβ25-35 (10 μM)....
Hepatic ischemia-reperfusion (IR) injury is a severe pathophysiological event during liver surgery or transplantation and could lead to failure even death. The energy supply of mitochondria plays an essential role in preventing IR injury. Mitochondrial DNA (mtDNA) involved maintaining the balance by participating oxidative phosphorylation process. However, exact relationship between mtDNA remains unclear reason lack accurate real-time analysis method. Herein, we fabricated...
Alzheimer's disease (AD) is a progressive neurological disease. Gut microbial dysbiosis associated with AD. This study involves the comparative assessment of spatial learning, β-amyloid peptide accumulation, and fecal microbiota alterations in 3×Tg-AD mice from 3 age groups: AD asymptomatic stage (3 m), presymptomatic (6 symptomatic (9 m). We demonstrate that memory deficits, brain Aβ weight gain gradually appear after 6 months age. However, total gut bacterial counts underwent changes to...
The Duffin-Kemmer-Petiau oscillator for spin 0 particle in noncommutative plane is analyzed and the energy eigenvalue of system obtained by employing functional analysis method. Furthermore, thermodynamic properties DKP are investigated via numerical method influence space on functions also discussed. We show that spectrum corresponding considered physical systems depend explicitly parameter<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract OBJECTIVES Combined large cell neuroendocrine carcinoma (C-LCNEC) is pulmonary (LCNEC) mixed with other components, such as adenocarcinoma (AD) and squamous (SCC). This study aimed to describe the distinct features between C-LCNEC different components explore treatment strategy. METHODS We retrospectively collected data of 96 patients who underwent surgical resection. Propensity score matching was used balance baseline characteristics LCNEC combined AD (LCNEC/AD) SCC (LCNEC/SCC)....
Abstract BACKGROUND Phenyllactic acid is an important monomer for bioplastics, food preservative, feed additive and pharmaceutical agent. However, bioproduction of phenyllactic suffers drawbacks regarding the high cost substrates, poor efficiency yield fermentation or conversion, therefore new strategies need to be investigated. RESULTS In this work, was developed by employing semi‐hydrophobic cryogels as cell entrapment matrices co‐culture Lactobacillus paracasei L. buchneri strains,...
We proposed a new strategy for <italic>in vivo</italic> evaluation of antidepressants through NIRF imaging mitochondrial Cys in the mouse brain.
Our study aimed to investigate the effects of alprostadil and Salvia miltiorrhiza extract on myocardial ischemia-reperfusion injury (IRI) related underlying molecular mechanisms. A IRI model was established in Wistar rats via surgical ligation left anterior descending coronary artery followed by loosening occlusion. The were divided into four groups: saline, sham, alprostadil, S. miltiorrhiza. Rats saline sham groups injected with normal tail vein once daily for 10 consecutive days. (20...
In 600 BC, the first pedicled direct cutaneous artery perforator flap-the supravicular flap was harvested by Sushruta. 1973, free superficial circumflex iliac in groin reported Daniel and Taylor. 1982, septocutaneous academician Zhong Shizhen. 1989, misculocutaneous Koshima. Reviewing history of surgery, there a fact that main evolutionary line course flap. future, clinical application traditional random (reticulated blood supply flap) axial will be more less, whereas flap, especially...
To determine the classification of masticatory myospasm by analyzing characteristics clinical appearances.Thirty-six cases from 2000 to 2010 were included. The data these patients analyzed, including patient information, history, characteristics, severity and frequency myospasmodic movement, electromyogram (EMG), efficacy botulinum toxin injection treatment.There 11 males 25 females, aged 15 71. According manifestation EMG findings, could be divided into two groups: 18 classified as jaw...