We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with risk type 2 diabetes (T2D) South Korea. Records 10,806,716 adults aged ≥ 20 years without a history T2D between 2009 2015 were retrieved from database Korean National Health Insurance Service analyzed. Changes metabolic monitored over two-year period follow-up occurring at an average 4.087 years. During period, 848,859 individuals diagnosed T2D. The was lowered decrease number MetS baseline...

The purpose of this study was to evaluate the association between blood manganese levels and prevalence chronic diseases in Korean population.This a cross-sectional based on National Health Nutrition Examination Survey (KNAHNES). included 3996 participants 20 years age or older whose had been measured. were also evaluated for presence five diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, stroke.Blood significantly lower diabetes group compared with non-diabetes...

p300/CBP-associated factor (PCAF), a histone acetyltransferase, is involved in many cellular processes such as differentiation, proliferation, apoptosis, and reaction to cell damage by modulating the activities of several genes proteins through acetylation either histones or transcription factors. Here, we examined pathogenic role PCAF its potential novel therapeutic target progression renal tubulointerstitial fibrosis induced non-diabetic unilateral ureteral obstruction (UUO) male C57BL/6...

Acute kidney injury (AKI) is characterized by an abrupt decline of excretory function. The incidence AKI has increased in the past decades. Patients diagnosed with often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from to chronic disease (CKD). Although recent studies have demonstrated strong association between progression CKD, our understanding complex relationship CKD still evolving. No cohort study succeeded painting...

Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role anthocyanins in diabetic nephropathy is poorly understood. We investigated whether anthocyanin-rich Seoritae extract (SE) can potentially prevent oxidative stress lipotoxicity, which the main causes renal damage nephropathy, via activation AMP-activated protein kinase (AMPK) consequent effects on its target molecules. Four groups male...

Objective— Recent data suggest that visit-to-visit variability of cholesterol is associated with cardiovascular events. We evaluated the role lipid as a determinant end-stage renal disease (ESRD). Approach and Results— Using nationally representative from Korean National Health Insurance System, 8 493 277 subjects who were free ESRD underwent ≥3 health examinations during 2005 to 2010 followed end 2015. Total (TC) was measured using coefficient variation, SD, independent mean. The primary...

This study examined the association between baseline BMI, percentage weight change, and risk of dementia in patients newly diagnosed with type 2 diabetes.Using South Korean National Health Insurance Service-National Screening Cohort database, we identified 167,876 subjects aged ≥40 years new-onset diabetes 2007 2012. Their changes were monitored for ∼2 after diagnosis, follow-up assessments occurring an average 3.5 years. The hazard ratios (HRs) Bonferroni-adjusted 95% CIs all-cause...

Because weight control is a cornerstone of diabetes management, it important to understand the relationship change risk cardiovascular disease (CVD) among patients with type 2 mellitus (DM). We aimed investigate whether changes in early after diagnosis influence incidence CVD and all-cause mortality DM. Using nationally representative data from Korean National Health Insurance System, 173,246 subjects new-onset DM who underwent health examinations during 2007–2012 were included. Weight was...

Intradialytic hypotension (IDH) is a serious complication of hemodialysis (HD) that associated with increased risks cardiovascular morbidity and mortality. However, its accurate prediction remains clinical challenge. The aim this study was to develop deep learning-based artificial intelligence (AI) model predict IDH using pre-dialysis features.Data from 2007 patients 943 220 HD sessions at seven university hospitals were used. performance the learning compared three machine models (logistic...

Malnutrition is a major issue in patients with chronic kidney disease (CKD), adversely affecting morbidity, mortality, functional activity and patients' quality of life. Our knowledge the pathogenic mechanisms malnutrition CKD, including endstage renal disease, has been improved. This led to development clinical practice guidelines for nutritional care CKD which provide framework issues facing physiccians. Extensive research field nutrition resulted formation general guidelines, although...

Renal interstitial fibrosis is a common final pathological process in the progression of kidney disease. This primarily due to oxidative stress, which contributes renal inflammation and fibrosis. Nuclear factor-erythroid-2-related factor 2 (Nrf2) known coordinate induction genes that encode antioxidant enzymes. We investigated effects oleanolic acid, Nrf2 activator, on stress-induced fibrosis.One day before unilateral ureteral obstruction (UUO) performed C57BL/6 mice, acid treatment was...

Although percutaneous renal biopsy remains an essential tool in the diagnosis and treatment of diseases, recent times traditional procedure nephrologists has been performed by non-nephrologists rather than at many institutions. The present study assessed safety adequacy tissue yield during according to practitioners techniques based on ultrasound.This included 658 native biopsies from 2005 2010 a single centre. were or expert ultrasound radiologists using ultrasound-marked blind real-time...

Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against tissue injury by orchestrating antioxidant and detoxification responses oxidative stress. This study investigated whether upregulation of Nrf2-dependent signaling oleanolic acid (OA), which activate Nrf2, could attenuate renal inflammation fibrosis in cyclosporine (CsA)-induced kidney injury. Male ICR mice were divided into four treatment groups: Vehicle (VH, n = 6), VH + OA (n CsA 8), 8). For the OA-treated...

The objective of this study was to investigate the optimal blood pressure (BP) target prevent development cardiovascular diseases (CVDs) in Korean subjects with type 2 diabetes mellitus. Using National Health Insurance Service database, 262 725 mellitus who underwent regular health checks between 2009 and 2012 were included. Subjects previous CVDs excluded. Participants grouped by 10-mm Hg intervals observed systolic BP (SBP) 5-mm diastolic BP. There 124 466 deaths (5.50%), 67 235 cases...

Besides lowering glucose, empagliflozin, a selective sodium-glucose cotransporter-2 (SGLT2) inhibitor, have been known to provide cardiovascular and renal protection due effects on diuresis natriuresis. However, the natriuretic effect of SGLT2 inhibitors has reported be transient, long-term data related diuretic change are sparse. This study was performed assess 12-week treatment with empagliflozin (3 mg/kg) in diabetic OLETF rats by comparing it other antihyperglycemic agents including...

Autophagy is a cellular process that degrades damaged cytoplasmic components and regulates cell death. The homeostasis of endothelial cells (ECs) crucial for the preservation glomerular structure function in aging. Here, we investigated precise mechanisms autophagy renal genetic deletion Atg7 ECs Atg7flox/flox;Tie2-Cre mice accelerated aging-related glomerulopathy tubulointerstitial fibrosis. EC-specific aging induced detachment EC with disruption basement membrane (GBM) assembly increased...

Background Postoperative acute kidney injury (AKI) is a significant risk associated with surgeries under general anesthesia, often leading to increased mortality and morbidity. Existing predictive models for postoperative AKI are usually limited specific surgical areas or require external validation. Objective We proposed build prediction model using several machine learning methods. Methods conducted retrospective cohort analysis of noncardiac from 2009 2019 at seven university hospitals in...

Fecal calprotectin (FC) is a biomarker of intestinal inflammation widely used in the assessment gastrointestinal disorders. However, its role chronic kidney disease (CKD) remains unclear. Given growing recognition gut-kidney axis CKD pathophysiology, this study aimed to investigate association between FC levels, systemic inflammation, renal outcomes, and mortality patients. We enrolled total 515 patients who underwent fecal measurement 2016 2023. After applying exclusion criteria...

Background Fabry disease is a rare X-linked genetic lysosomal disorder caused by mutations in the GLA gene encoding alpha-galactosidase A. Despite some data showing that profibrotic and proinflammatory cytokines oxidative stress could be involved disease-related renal injury, pathogenic link between metabolic derangement within cells injury remains unclear. Methods Renal fibrosis was triggered unilateral ureteral obstruction (UUO) mice with to investigate mechanism leading diseased kidneys....

The aim of this study was to assess any potential additive effects a treatment combining aliskiren with paricalcitol on reducing renal fibrosis. C57BL/6J mice were treated individually and/or until 7 days after initiation unilateral ureteral obstruction (UUO).In obstructed kidneys UUO mice, monotherapy or significantly attenuated interstitial fibrosis, collagen IV accumulation, and α-smooth muscle actin- terminal deoxynucleotidyl transferase-mediated biotin nick end-labeling-positive cells....