A5082708152- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Vector-Borne Animal Diseases
- Study of Mite Species
- Influenza Virus Research Studies
- Yersinia bacterium, plague, ectoparasites research
- Bird parasitology and diseases
- interferon and immune responses
- Immune Response and Inflammation
- Leptospirosis research and findings
- Dengue and Mosquito Control Research
- Bacterial Identification and Susceptibility Testing
- Brucella: diagnosis, epidemiology, treatment
- Data-Driven Disease Surveillance
- Inflammasome and immune disorders
- Respiratory viral infections research
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Bartonella species infections research
- Diphtheria, Corynebacterium, and Tetanus
- Microscopic Colitis
- Inflammatory Bowel Disease
Levine Children's Hospital
2025
University of Liverpool
2022-2024
University of Malaya
1993-2023
University Malaya Medical Centre
2015-2023
King Saud University
2023
Imam Mohammad ibn Saud Islamic University
2023
Al Baha University
2023
National University of Malaysia
2022
Monash University Malaysia
2014-2017
Sultanah Aminah Hospital
2001-2017
Ticks are vectors in the transmission of many important infectious diseases human and animals. can be readily found semi-forested areas such as settlements indigenous people Malaysia, Orang Asli. There is still minimal information available on bacterial agents associated with ticks Malaysia. We performed a survey communities collected from domestic animals two Asli villages 62 ticks, microscopically molecularly identified related to Haemaphysalis wellingtoni, hystricis bispinosa. Bacterial...
While fleas are often perceived simply as a biting nuisance and cause of allergic dermatitis, they represent important disease vectors worldwide, especially for bacterial zoonoses such plague (transmitted by rodent fleas) some the rickettsioses bartonelloses. The cosmopolitan cat ( Ctenocephalides felis ) dog canis fleas, well orientis (restricted to tropical subtropical Asia), breed in human dwellings cat-scratch fever (caused Bartonella spp.) Rickettsia spp., including (agent flea-borne...
Recent studies have shown that ticks harbor Coxiella-like bacteria, which are potentially tick-specific endosymbionts. We recently described the detection of bacteria and possibly Coxiella burnetii in found from rural areas Malaysia. In present study, we collected ticks, including Haemaphysalis bispinosa, hystricis, Dermacentor compactus, steini, Amblyomma sp. wildlife domesticated goats four different locations 16s rRNA genomic sequences were detected by PCR 89% tested. Similarity analysis...
The innate immune response to virus must be balanced eliminate infection yet limit damaging inflammation. A critical arm of the antiviral is launched by retinoic acid-inducible-gene I (RIG-I) protein. RIG-I activated viral RNA then associates with mitochondrial signaling (MAVS) protein subsequently induce potent inflammatory cytokines. Here, we demonstrate E3 ubiquitin ligase 1 (MUL1) a crucial moderator signaling. MUL1 localized mitochondria where it interacts MAVS and catalyzes...
Chigger mites are vectors of the bacterial disease scrub typhus, caused by Orientia spp. The bacterium is vertically transmitted in vector and horizontally to terrestrial vertebrates (primarily wild small mammals), with humans as incidental hosts. Previous studies have shown that size chigger populations correlated density mammals typhus-endemic regions. Here, we explore interactions between chiggers two oil palm plantations located Perak Johor states Peninsular Malaysia. location also...
Spirochetes from the Borrelia genus are known to cause diseases in humans, namely Lyme disease and relapsing fever. These organisms commonly transmitted humans by arthropod vectors including ticks, mite, lice. Here, we report molecular detection of a sp. Haemaphysalis hystricis Supino tick collected wildlife an Orang Asli settlement Selangor, Malaysia. Phylogenetic analyses partial 16s rRNA flaB gene sequences revealed that is closely related fever group borreliae, lonestari, miyamotoi,...
Abstract BACKGROUND Upadacinitib (UPA), a narrow spectrum Janus kinase inhibitor, is an FDA-approved therapy for adults with inflammatory bowel disease (IBD). It not currently approved pediatric IBD and instead must be used as off-label therapy. This case series describes single-center experience using UPA in adolescents salvage acute severe colitis (ASC) to provide clinical data safety efficacy. METHODS was descriptive of six patients aged 12 16 years who were started on ASC between...
ABSTRACT Transjugular intrahepatic portosystemic shunt (TIPS) creation is an effective approach to address the complications of portal hypertension. This case report describes adolescent boy who underwent TIPS with expanded polytetrafluorethylene-lined stent graft for hypertension secondary sinusoidal obstruction syndrome. He subsequently developed microangiopathic hemolytic anemia, uncommon complication covered stents that not well reported in pediatric population. Despite its rarity and...
INTRODUCTION/BACKGROUND Adrenal tuberculosis (TB) is a rare but serious form of extrapulmonary TB, accounting for 7% to 20% primary adrenal insufficiency (PAI) cases worldwide. It typically results from haematogenous spread, leading granulomatous inflammation, caseous necrosis and progressive destruction. Despite appropriate anti-TB therapy, PAI can develop weeks months later due ongoing damage. CASE A 68-year-old Malay male with type 2 diabetes mellitus, hypertension ischaemic heart disease...
INTRODUCTION/BACKGROUND Primary hyperparathyroidism (PHPT) due to parathyroid adenoma often requires parathyroidectomy. However, surgery may not be feasible in high-risk patients. Thermal ablation techniques, such as microwave (MWA), offer a minimally invasive alternative. We present case of an elderly woman who was successfully treated with for severe hypercalcemia caused by adenoma. METHODOLOGY An 81-year-old semi-dependent female diagnosed hormone (PTH)-dependent 2020 calcium level at 3.4...
Abstract Outbreaks involving the Asian genotype Chikungunya virus (CHIKV) caused over one million infections in Americas recently. The outbreak was preceded by a major nationwide Philippines. We examined phylogenetic and phylogeographic relationships of representative CHIKV isolates obtained from 2012 Philippines with other collected globally. isolated Philippines, China, Micronesia Caribbean regions were found closely related, herein denoted as Cosmopolitan (CACV). Three adaptive amino acid...
The Borrelia genus consists of spirochete bacteria known to cause Lyme disease (LD) and relapsing fever in humans. pathogens are commonly transmitted via arthropod vectors such as ticks, mites, or lice. Here, we report the molecular screening LD group sp. from ticks (Acari: Ixodidae) collected rodents trapped recreational forests a semiurban residential area Selangor state Malaysia. Of 156 adult surveyed, 72 were determined positive for by polymerase chain reaction (PCR). All PCR-positive...
Wolbachia are intracellular endosymbionts of several invertebrate taxa, including insects and nematodes. Although DNA has been detected in ticks, its presence is generally associated with parasitism by insects. To determine whether or not can infect grow tick cells, cell lines from three species, Ixodes scapularis, ricinus Rhipicephalus microplus, were inoculated strains wStri wAlbB isolated mosquito lines. Homogenates prepared fleas collected cats Malaysia into an I. scapularis line....
Lyme disease has been well-described in the North America and European countries. However, information is still very limited developing countries including Malaysia. The Orang Asli (OA), indigenous people of Peninsular Malaysia reside mostly forest fringe areas abundant with vector for disease. Here, we described seroprevalence Borellia burgdorferi (B. burgdorferi) among OA demographic variables that could be associated seroprevalence.A total 16 villages distributed across 8 states...
Neoschoengastia gallinarum is widely distributed in Asia, preferentially parasitising birds, and heavy infestations have clinical impacts on domestic fowl. In common with other trombiculid mites, the genetic diversity potential variation host preferences or pathology induced by N. are poorly understood. This study aimed to unravel geographical population structure of collected from galliform birds Peninsular Malaysia Thailand inference concatenated mitochondrial-encoded cytochrome c oxidase...
Mosquito-borne diseases are rapidly spreading in all regions of the world with an estimation 2.5 billion people globally at risk. The recent surge dengue outbreaks has caused severe affliction to Malaysian society. Hence, ability predict a outbreak and mitigate its damage loss proactively is very critical. In this paper, we study possibility applying machine learning (ML) deep (DL) approaches number confirmed fever (DF) cases Kuala Lumpur. We identified several contribution factors correlate...
Scrub typhus is a zoonosis caused by 3 species of Orientia bacteria, including Candidatus chuto. This known only from human case in Dubai and infections wildlife Kenya. We report molecular detection O. chuto 2 wild rodent Saudi Arabia.