A5034799601- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Enhanced Recovery After Surgery
- Palliative Care and End-of-Life Issues
- Global Cancer Incidence and Screening
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Endometriosis Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Renal cell carcinoma treatment
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Gynecological conditions and treatments
- Economic and Financial Impacts of Cancer
University of Alabama at Birmingham
2016-2025
Gynecologic Oncology Group
2004-2023
Community Link
2021
University of Alabama
1975-2016
The Ohio State University
2009-2011
Washington University in St. Louis
2007
Clayton College of Natural Health
2006
Weatherford College
2005
To determine whether the addition of bevacizumab to paclitaxel and carboplatin for primary treatment advanced ovarian cancer can be cost effective.A cost-effectiveness analysis compared three arms Gynecologic Oncology Group (GOG) 218 study (paclitaxel plus [PC], PC [PCB], PCB maintenance [PCB+B]). Actual estimated costs potential complications were established each strategy. Progression-free survival (PFS) bowel perforation rates taken from recently reported results GOG 218. Sensitivity was...
In Brief OBJECTIVE: To prospectively evaluate in a blinded fashion the accuracy of frozen section endometrial cancer. METHODS: Sixty patients with cancer or complex atypical hyperplasia were consecutively enrolled. Intraoperatively, was obtained, processed, and stored for interpretation by pathologists. Final pathologic diagnosis conducted usual pathologists to results. Histologic grade myometrial invasion on correlated final pathology. RESULTS: Median age 61 years (range, 39–82 years)....
Our purpose was to study the safety, distribution, pharmacokinetics, immunogenicity, and tumor response of intraperitoneal <sup>212</sup>Pb-TCMC-trastuzumab (TCMC is S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane) in patients with human epidermal growth factor receptor type 2 (HER-2)–expressing malignancy. <b>Methods:</b> In a standard 3 + phase 1 design for dose escalation, delivered intraperitoneally less than 4 h after administration...
Purpose: One-year monitoring of patients receiving intraperitoneal (IP) 212 Pb-TCMC-trastuzumab to provide long-term safety and outcome data. A secondary objective was study 7 tumor markers for correlation with outcome. Methods: Eighteen relapsed intra-abdominal human epidermal growth factor receptor-2 expressing peritoneal metastases were treated a single IP infusion Pb-TCMC-trastuzumab, delivered <4 h after 4 mg/kg IV trastuzumab. Seven studied Results: Six dose levels (7.4, 9.6, 12.6,...
While high-grade serous ovarian carcinoma (HGSOC) is the most common histologic subtype of cancer, significant tumor heterogeneity exists. In addition, chemotherapy induces changes in gene expression and alters mutational profile. To evaluate notion that patients with HGSOC could be better classified for optimal treatment based on expression, we compared genetic variants [by DNA next-generation sequencing (NGS) using a 50 Ion Torrent panel] (using NanoString PanCancer 770 Panel) from 20...
The objective of this study was to evaluate the treatment outcomes and risk factors women with surgical stage I endometrial adenocarcinoma who were initially treated surgery alone subsequently developed isolated vaginal recurrences. Patients diagnosed from 1975 2002 identified tumor registry databases at seven institutions. All patients including a total hysterectomy, bilateral salpingo-oophorectomy, pelvic (+/- para-aortic) lymph node dissection, peritoneal cytology did not receive...