A5059138509- Reproductive Biology and Fertility
- Bacillus and Francisella bacterial research
- Legionella and Acanthamoeba research
- Angiogenesis and VEGF in Cancer
- Hematopoietic Stem Cell Transplantation
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- Reproductive Physiology in Livestock
- Poxvirus research and outbreaks
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Polyomavirus and related diseases
- Vibrio bacteria research studies
- Pluripotent Stem Cells Research
- Viral Infections and Outbreaks Research
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- TGF-β signaling in diseases
- Ovarian function and disorders
- Virus-based gene therapy research
- Yersinia bacterium, plague, ectoparasites research
- Viral gastroenteritis research and epidemiology
- Hip disorders and treatments
Osaka University
2022-2025
Yamaguchi University
2014-2024
Nagoya University
2024
Showa University
2023
Hokkaido University
2018
Tokyo University of Agriculture
2018
Sapporo Medical University
2005-2017
Gifu Municipal Hospital
2013
Obihiro University of Agriculture and Veterinary Medicine
2006-2012
Kurume University
2001-2012
Abstract The pathogenesis of Mycoplasma pneumoniae infection is considered to be in part attributed excessive immune responses. Recently, lipoproteins from mycoplasmas have been reported induce NF-κB activation. In this study, we examined the ability M. activate NF-κB, and active component responsible for activation was identified. Lipid-associated membrane proteins were found through TLR 2 a human monocytic cell line, THP-1. subunit b F0F1-type ATPase (F0F1-ATPase). F0F1-ATPase assumed...
The Pseudomonas aeruginosa-derived alkaline protease (AprA), elastase A (LasA), B (LasB) and IV are considered to play an important role in pathogenesis of this organism. Although the sequence analysis P. aeruginosa genome predicts presence several genes encoding other potential proteases genome, little has been known about involving pathogenesis. Recently, Porphyromonas gingivalis gingipains Serratia marcescens serralysin have shown activate protease-activated receptor 2 (PAR-2), thereby...
ABSTRACT Mycoplasma pneumoniae causes pneumonia, tracheobronchitis, pharyngitis, and asthma in humans. The pathogenesis of M. infection is attributed to excessive immune responses. We previously demonstrated that lipoproteins induced inflammatory responses through Toll-like receptor 2 (TLR2). In the present study, we strong macrophages derived from TLR2 knockout (KO) mice. Cytokine production KO was increased compared with wild-type (WT) Heat-killed, antibiotic-treated, overgrown failed...
The Serratia marcescens-derived protease serralysin is considered to play an important role in the pathogenesis of infection. Protease-activated receptor 2 (PAR-2) activated by trypsin and also several other trypsin-like serine proteases, leading modulation inflammatory immune responses. However, little known about activation PAR-2 bacterial proteases its roles In this study, we investigated whether S. marcescens activates host responses through PAR-2. Our results demonstrated that induces...
The present study characterizes gliding motility mutants of Mycoplasma mobile which were obtained by UV irradiation. They identified their abnormal colony shapes in 0·1% agar medium, showing a reduced number satellite colonies compared to the wild-type. A total ten isolated based on phenotype. Using dark-field and electron microscopy, two classes mutants, group I II, defined. Cells had irregular, flexible sometimes elongated head-like structures showed tendency aggregate. Neither binding...
The interaction between angiogenic factors and related receptors is closely associated with follicular angiogenesis. present study was performed to determine the relationships capillary network mRNA expression of several during porcine development. Ovaries in gilts were collected 72 h after eCG (1250 IU) treatment for histological observation. Granulosa cells thecal tissues small (diameter, <4 mm), medium 4–5 or large >5 mm) individual follicles detection vascular endothelial growth factor...
Heat stress inhibits ovarian follicular development in mammalian species. We hypothesized that heat the function of granulosa cells and suppresses development. To test this, immature female rats were injected with pregnant mare serum gonadotropin (PMSG) at 48 h after start temperature treatment (control: 25 degrees C, 50% RH; stress: 35 70% Relative Humidity). The ovaries follicles different developmental stages analyzed for receptor levels aromatase activity; estradiol measured fluid....
Abstract Legionella pneumophila , the causative agent of Legionnaires’ disease, replicates within alveolar macrophages and free-living amoebae. However, lifestyle L. in environment remains largely unknown. Here we established a novel natural host model endosymbiosis using ciliate Paramecium caudatum . We also identified endosymbiosis-modulating factor A (LefA), which contributes to change life stage from lysis, enabling escape environment. isolated strains they exhibited cytotoxicity toward...
Pseudomonas aeruginosa-derived large extracellular protease (LepA) and hemolytic phospholipase C (PlcH) are considered to play an important role in the pathogenicity of this organism. Although bacterial growth appears be closely related virulence, little is known about whether LepA PlcH participate virulence P. aeruginosa. In study, we investigated contribute aeruginosa using a wild-type strain mutants. The rate isogenic lepA single mutant was lower than that minimal medium containing serum...
Growth differentiation factor-9 (GDF-9) and bone morphogenetic proteins (BMPs) are crucial factors in follicular growth development. GDF-9 BMPs initiate signaling by assembling type I (ALK-3, ALK-5 ALK-6) II (BMPRII) receptors. However, the mechanism regulating expression of these receptors process bovine follicle development is still unknown. The aim present study was to clarify involvement receptor systems for selection examining effects FSH estradiol-17β (E2) on regulation BMPRII, ALK-3,...
Radiation-induced cavernous hemangioma (RICH) is a late complication of cerebral radiation therapy. Long-term survivors hematopoietic stem cell transplantation (HSCT) who underwent therapy could be at increased risk for RICH. We investigated records 68 patients HSCT during childhood or adolescence and were assessed by magnetic resonance imaging (MRI), including T2*-weighted the brain, annually 5 years over range 6 to 29 after HSCT. developed scoring grading system RICH monitor process...
Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. Despite extensive research on Hp glycosylation as glyco-biomarker for cancers, understanding glycosylated modifications in sepsis patients (SPs) remains limited. Our study reveals elevated levels terminal fucosylation at Asn207 Asn211 SP plasma, along heightened responses, compared to healthy controls (trial registration NCT05911711)....
Summary Mycoplasmas are known to enhance human immunodeficiency virus (HIV) replication, and mycoplasma‐derived lipid extracts have been reported activate nuclear factor‐κB (NF‐κB) through Toll‐like receptors (TLRs). In this study, we examined the involvement of TLRs in activation HIV long‐terminal repeats (LTR) by mycoplasma their active components responsible for TLR activation. Lipid‐associated membrane proteins (LAMPs) from two species ( Mycoplasma fermentans M. penetrans ) that...
To address the role of follicular angiogenesis in determination ovulatory follicles and effects different vascular endothelial growth factor (VEGF) isoforms on development, mature female rats were treated with an angiogenic inhibitor (TNP-470), also VEGF 120 or 164 at dosages (0.4, 0.8, 4.0 8.0 μg/kg body weight) for 3 days during estrous cycle. Ovarian angiogenesis, population large ovulation examined. (0.8 μg/kg) (8.0 treatments stimulated theca interna layer, while TNP-470 treatment...
Growth differentiation factor-9 (GDF-9) is a growth factor secreted by oocytes in growing ovarian follicles. To investigate the function of GDF-9 pigs, we first cloned porcine complementary DNA (cDNA), and then injected its gene fragments into ovary gilts. Porcine has open reading frame (ORF) homologies 81.4%, 84.6%, 84.2%, 72.7% 72.6% with human, bovine, ovine, rat mouse counterparts respectively. Regarding deduced amino-acid sequence mature protein, corresponding reach 92.1%, 97.8%, 97.0%,...