A5042631712- Chemical Reactions and Isotopes
- Biochemical effects in animals
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Mass Spectrometry Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Muon and positron interactions and applications
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Regulation of Appetite and Obesity
- Synthesis and Biological Evaluation
- Human Health and Disease
- Mental Health Research Topics
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Fluorine in Organic Chemistry
- Diet, Metabolism, and Disease
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Chemical Synthesis and Characterization
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
Kurchatov Institute
2016-2025
Czech Academy of Sciences, Institute of Molecular Genetics
2021-2025
Institute of Molecular Genetics
2015-2024
Mental Health Research Center of Russian Academy of Medical Sciences
2017-2023
Russian Academy of Sciences
2013-2022
Institute of Physiologically Active Compounds
1998-2020
Ministry of Health of the Russian Federation
2019
Lomonosov Moscow State University
2002-2013
A. N. Nesmeyanov Institute of Organoelement Compounds
1999-2013
N.D. Zelinsky Institute of Organic Chemistry
2013
The data from the spectrum measurement of tritium decay in a valine molecule carried out wide energy range (3.4 keV) with Institute Theoretical and Experimental Physics spectrometer are analyzed. combined analysis both these previous cycle gives neutrino mass ${30.3}_{\ensuremath{-}8}^{+2}$ eV. model-independent interval $17<{M}_{\ensuremath{\nu}}<40$ eV is derived difference doublet $^{3}\mathrm{H}$-$^{3}\mathrm{He}$.
The phytohormone abscisic acid (ABA) plays an important role in plant growth and response to abiotic stress factors. At the same time, its accumulation soil can negatively affect seed germination, inhibit root increase sensitivity pathogens. ABA is inert compound resistant spontaneous hydrolysis biological transformation scarcely understood. Recently, strain Rhodococcus sp. P1Y was described as a rhizosphere bacterium assimilating sole carbon source batch culture affecting concentrations...
Clinical studies have shown the similarity of spectrum physiological effects Selank and classical benzodiazepines, such as diazepam phenazepam. These data suggest that there is a similar basis their mechanism action. To test this hypothesis we studied effect GABA on expression genes involved in neuroreсeption neurotransmission. We analyzed 84 (e.g., major subunit receptor, transporters, ion channels, dopamine serotonin receptors) frontal cortex rats 1 3 hours after administration or (300...
The work is devoted to the screening study of psychotropic activity regulatory peptides a number glyprolins and melanocortins in conditions thyroid hyperfunction. Material methods. was carried out on male rats divided into groups: I – intact (control); II individuals with experimental hyperthyroidism; III, IV, V, VI, VII VIII animals induced hyperthyroidism receiving Thr-Lys-Pro-Arg-Pro-Gly-Pro, ACTH(4-7)-Pro-Gly-Pro, ACTH(6-9)-Pro-Gly-Pro, Pro-Gly-Pro, Pro-Gly-Pro-Leu, Arg-Pro-Gly-Pro,...
The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, molecular mechanisms underlying its action remain obscure. Our genome-wide study was designed to investigate response transcriptome ischemized rat cortex tissues vivo. gene-expression alteration caused by compared with gene expression "ischemia" group animals at 3 and 24 h after permanent middle cerebral artery occlusion (pMCAO). predominantly enhanced genes...
Natural regulatory peptides are biologically active compounds that produced by various cells and provide a link among the main systems of body. The field research into biologic activity endogenous is extremely vast. These affect cardiovascular, immune, reproductive, endocrine, digestive, other systems, alter energy metabolism, especially effective in regulation central nervous system. Despite wide range preventive therapeutic effects natural proteins, their application clinical practice...
Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in treatment patients with severe impairment cerebral blood circulation. However, its molecular mechanisms action within are not yet fully understood. Previously, we transient middle artery occlusion (tMCAO) model to study damaging...
The present concept of relative instability regulatory peptides (RPs) in organisms must be amended. recently characterized family glyprolines and some other prolyl-glycyl-proline (PGP)-containing oligopeptides show the stability quite comparable with those major pharmacological preparations. ability to pass gastro-enteric tract barriers opens ways per-oral administration this new group drugs such as semax, selank their fragments. most interesting approach is creation hybrid ("chimeric")...
Abstract Modern theories about the processes that take place inside solvent‐free catalyst systems are considered and various factors have an effect on successful introduction of tritium into organic compounds summarized. Obtaining labelled using systems, liquid‐phase methods, isotopic exchange with tritiated water all regarded as manifestations same set occurrences in presence tritium, a substrate catalyst. The use methods has made possible practically any type biologically active compound....
Nearly 30 synthetic nucleosides were tested with human recombinant poly(ADP-ribose) polymerase 1 as potential inhibitors of this enzyme. The most active compounds some disaccharide analogues thymidine: 3′-O-β-D-ribofuranosyl-5-iodo-dUrd (2d; IC50 = 45 μM), 3′-O-β-D-ribofuranosyl-2′-deoxythymidine (2e; 38 and oxidized (4; 25 μM). These also reduced H2O2-induced synthesis in cultured ovarian carcinoma (SKOV-3) cells a dose-dependent manner. Furthermore, 2d or 2e until concentration mM did not...
Comparative analysis of the hypocholesterolemic and antithrombotic action small regulatory glyproline peptides (Pro-Gly-Pro, Arg-Pro-Gly-Pro Pro-Gly-Pro-Leu) was performed on an experimental hypercholesterolemia model rats. Repeated intranasal introduction to fat-diet-fed animals led more active functioning anticoagulation system (the anticoagulant fibrinolytic properties plasma increased platelet aggregation decreased) normalization total cholesterol level as a parameter lipid metabolism....
To compare the efficacy and tolerability of monotherapy with phenazepam to complex treatment peptide preparation selank in patients anxiety disorders.Authors explored anxiolytic effect (30 patients) (40 anxiety-phobic, hypochondriac somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2). Therapeutic was assessed clinically HDRS, CGI Spilberger scales. Tolerability evaluated using UKU scale. Stroop test verbal fluency were used. Quality life SF-36.The positive achieved earlier...
Natural melanocortins (MCs) have been used in the successful development of drugs with neuroprotective properties. Here, we studied behavioral effects and molecular genetic mechanisms two synthetic MC derivatives-ACTH(4–7)PGP (Semax) ACTH(6–9)PGP under normal acute restraint stress (ARS) conditions. Administration Semax or (100 μg/kg) to rats 30 min before ARS attenuated ARS-induced alterations. Using high-throughput RNA sequencing (RNA-Seq), identified 1359 differentially expressed genes...