A5008071991- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Calcium signaling and nucleotide metabolism
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes and associated disorders
- Lysosomal Storage Disorders Research
- Cardiac Fibrosis and Remodeling
- melanin and skin pigmentation
- Muscle metabolism and nutrition
- Immune cells in cancer
- Infrared Thermography in Medicine
- Fatty Acid Research and Health
- Retinal Development and Disorders
- Connexins and lens biology
German Center for Diabetes Research
2016-2025
Heinrich Heine University Düsseldorf
2016-2025
Deutsches Diabetes-Zentrum e.V.
2016-2025
German Institute of Human Nutrition
2016-2025
Friedrich Schiller University Jena
2010-2015
University of Hohenheim
2008-2013
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production ROS during phosphorylation. The hypothesis exists that mitochondria are involved formation lipofuscin, an autofluorescent protein aggregate accumulates progressively over time lysosomes post-mitotic senescent cells. To investigate influence involvement lipofuscinogenesis, we analyzed lipofuscin amounts as well mitochondrial function young In addition used model Lon...
The overall decrease in proteolytic activity aging can promote and accelerate protein accumulation metabolic disturbances. To specifically analyze changes macroautophagy (MA) we quantified different autophagy-related proteins (ATGs) young, adult old murine tissue as well young senescent human fibroblasts. Thus, revealed significantly reduced levels of ATG5-ATG12, LC3-II/LC3-I ratio, Beclin-1 p62 brain investigate the role mTOR, itself its target p70S6 kinase 4E-BP1 were quantified....
AGEs (advanced glycation-end products) accumulate during aging and several pathologies such as Alzheimer's disease diabetes. These protein products are known to inhibit proteolytic pathways. Moreover, be involved in the activation of immune responses. In present study we demonstrate that induce expression immunoproteasomal subunits. To elucidate a molecular basis underlying observed effects were able an Jak2 (Janus kinase 2)/STAT1 (signal transducer activator transcription 1) pathway....
Abstract Research in aging often refers to animal models, particularly C57BL/6J (B6J) mice, considered gold standard. However, B6J mice are distributed by different suppliers, which results divers substrains exhibiting notable phenotypic differences. To ensure a suitable phenotype of cardiac aging, we performed heart analyses young (5 months) and old (24 from two substrains: B6JRj (Janvier) B6JCrl (Charles River). In hearts both substrains, myocardial fibrosis increased with age; however,...