A5010135139- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Renal and related cancers
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Glaucoma and retinal disorders
- Cardiac electrophysiology and arrhythmias
- RNA Interference and Gene Delivery
- Cardiac Ischemia and Reperfusion
- Corneal surgery and disorders
- Burn Injury Management and Outcomes
- Immune cells in cancer
- Renal and Vascular Pathologies
- Corneal Surgery and Treatments
- Cardiac Imaging and Diagnostics
Aarhus University
2021-2025
University of Cologne
2017
Acute kidney injury (AKI) is an important risk factor for chronic disease (CKD), but the underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely understood. In this study, we aimed dynamic tracking remodeling to understand if focal upon AKI may spread over time. Here, present a model AKI, in which rendered only half ischemic. Using serial intravital 2-photon microscopy genetic identification cycling cells, tracked tissue post- non-ischemic regions simultaneously...
The spleen plays a key role in clearing blood-borne infections and is involved autoimmune hematological disorders. It undergoes extensive remodeling during inflammation immune reactions, but its localization the peritoneal cavity has hampered studies of these dynamic changes. Here, we establish validate protocol for serial 2-photon microscopy murine to capture processes living animal. As proof-of-principle, elucidate expansion contraction autoreactive germinal centers (GCs) induced by...
CpG-oligodeoxynucleotide (CpG ODN)-based toll-like receptor (TLR) agonists are promising immunostimulatory adjuvants, however, low entry into TLR-rich cellular endosomal compartments and poor lymphatic accumulation limit clinical translation. In this work, we introduce a recombinant human serum albumin (rHA)-CpG ODN covalent conjugate (rHA-CpG) designed to exploit the neonatal Fc (FcRn)-driven sorting pathway maximise CpG delivery TLR9-rich endosomes accumulate in lymph nodes. Site-selective...
Abstract Acute kidney injury (AKI) is an important risk factor for chronic disease (CKD), but the underlying mechanisms of failed tubule repair and AKI-CKD-transition are incompletely understood. In this study, we aimed dynamic tracking remodeling to understand if focal upon AKI may spread over time. Here present a novel model AKI, in which rendered only half ischemic. Using serial intravital 2-photon microscopy genetic identification cycling cells, tracked tissue post- non-ischemic regions...
Myofibroblasts were suggested to play a pivotal role in the transition of acute kidney injury (AKI) chronic disease, by engaging progressive and self-perpetuating tubulointerstitial fibrosis. Wound healing from AKI gives rise myofibroblast-activation renal interstitial PDGFRβ-cells. In this study, we exploited novel model partial ischemia reperfusion (IRI), track dynamic PDGFRbeta-cell interactions with injured non-injured tissue over time addressed question if how myofibroblast-derived...
Bordoni, Luca; Pohl, Layla; Kristensen, Anders M.; Kidmose, Hanne; Sardella, Donato; Schiessl, Ina Laboratory of Renal Cell Remodeling and Regeneration (The Schiessl-lab) Author Information