Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a type 2 diabetes mellitus (T2DM) treatment with demonstrated weight loss benefits in clinical trials. However, the extent to which real-world patients T2DM achieve clinically meaningful (≥5%) has not been well characterized. Analysis of data suggests adherence injectable GLP-1 RAs is suboptimal and discontinuation following first year therapy poorly Research design methods A retrospective cohort study among initiating RA...

Estimates of psoriatic arthritis (PsA) prevalence among psoriasis patients vary widely (5-40%). The time to development PsA in with plaque also remains unclear.To examine whether length since diagnosis affects risk developing PsA, and assess differences quality life (QoL), work-related issues, comorbidities healthcare resource utilization (HCRU) for vs. psoriasis.This large cross-sectional observational study was conducted the UK, Italy, France, Spain Germany 2006. Dermatologists who...

Abstract Background Pruritus is a clinically important symptom of psoriasis that has major impact on quality life (QoL). Objective The objective this study was to examine pruritus and QoL in patients with moderate‐to‐severe treated etanercept (ETN) the PRISTINE clinical trial. Methods Patients were randomized (1 : 1, double‐blind) ETN 50 mg QW or BIW for 12 weeks, followed by weeks. reported as 0 (no itching) 5 (severe itching). Associations examined between Psoriasis Area Severity Index,...

To assess adherence and discontinuation of injectable glucagon-like peptide-1 receptor agonists (GLP-1 RA) at 12 24 months among adult type 2 diabetes mellitus (T2DM) patients in the United States initiating GLP-1 RA using administrative claims-based database, Optum Clinformatics® Data Mart 7.1.A retrospective study was conducted from 01/2009 to 12/2017. Patients were required be continuously enrolled for prior their first prescription. Proportion days covered (PDC) prescription claims ≥0.80...

Moderate/severe psoriasis combined with psoriatic arthritis (PsA) impairs health-related quality of life (QoL). Etanercept, a fully human tumour necrosis factor-α receptor fusion protein, is approved for treatment both diseases.To compare patient-reported health outcomes (PROs) two etanercept regimens in patients moderate/severe and PsA.In this randomized, double-blind, multicenter study, participants received 50 mg twice weekly (BIW; n = 379) or (QW; 373) 12 weeks open-label QW additional...

<i>Objective:</i> To assess baseline patient-reported outcomes (PROs) and PRO improvement in patients with psoriasis administered etanercept 50 mg once weekly (QW). <i>Methods:</i> Adult moderate-to-severe plaque participated a 12-week, double-blind, controlled trial which they received QW (n = 96) or placebo 46), followed by open-label extension (etanercept-etanercept, n 90; placebo-etanercept, 36). Patients completed the Dermatology Life Quality Index (DLQI),...

Efficacy of biologic therapies for psoriasis has been demonstrated in randomized trials, but effectiveness real-world settings yet to be fully determined.To compare clinical improvement and treatment satisfaction with versus other patients plaque psoriasis.European dermatologists recruited into an observational study. Dermatologists reported disease severity before after starting current therapy; satisfaction.These analyses included 2151 patients: topicals, n = 453; phototherapy, 666;...

Background This cross-sectional study estimated prevalence and health-related burden of possible refractory or unexplained chronic cough (RCC). Methods secondary analysis survey data from France, Germany, Italy, Spain included respondents who self–reported current (CC; ≥8 weeks) no smoking/vaping, lung cancer history, interstitial disease, angiotensin-converting enzyme inhibitor/oral steroid use. Respondents scored ≥4 (of 10) on a severity visual analog scale did not report “a great deal”...

Cardiometabolic, clinical and quality-of-life (QoL) measures were assessed before after etanercept treatment in patients who had moderate-to-severe plaque psoriasis with without psoriatic arthritis (PsA) the PRISTINE trial. Adult randomized to receive 50 mg once weekly or twice double-blind for 12 weeks; all subsequently received open-label through week 24. Metabolic syndrome was identified 44 41% of PsA, elevated blood pressure 73 56% (p < 0.05) diabetes 21 9% 0.01), respectively....

While glycemic control is key in effective type 2 diabetes mellitus management, many patients fail to reach their individualized goal. This analysis aimed describe a real-world picture of management: hemoglobin A1c (HbA1c) goals, rate goal attainment, HbA1c at each line therapy, and patient awareness Secondly, we understand physician satisfaction with amongst aware vs. those unaware Analysis physicians the next ten consulting conducted Europe USA including medical record data...

Objective: To determine the effects of budesonide and formoterol administered via one pressurized metered-dose inhaler (budesonide/formoterol pMDI) on patient-reported outcomes (PROs) to contributions those in adults with asthma.Research design methods: A 12-week, random­ized, double-blind, double-dummy, placebo-controlled, multicenter study was conducted 480 patients aged ≥ 12 years mild-to-moderate persistent asthma. After a 2-week run-in period during which current asthma therapy...

BACKGROUND: Statins are effective in helping prevent cardiovascular disease (CVD). However, studies suggest that only 20%-64% of patients taking statins achieve reasonable low-density lipoprotein cholesterol (LDL-C) thresholds. On-treatment levels LDL-C remain a key predictor residual CVD event risk. OBJECTIVES: To (a) determine how many on achieved the therapeutic threshold < 100 mg per dL (general cohort) and 70 (secondary prevention cohort, or subcohort, with preexisting CVD); (b)...

Belimumab is an approved therapy for the treatment of systemic lupus erythematosus (SLE). This study examined real-world utilization patterns belimumab and standard SLE therapies in patients after regulatory approval United States.A retrospective, observational users HealthCore Integrated Research Database was conducted using administrative claims data (GlaxoSmithKline Clinical Study Register ID: 114955). The overall population analysis composed who were prescribed belimumab, had ≥6 months...

Psoriasis and psoriatic arthritis (PsA) impair quality of life, including reduction in employment or job duties. The PRESTA (Psoriasis Randomized Etanercept STudy Patients with Psoriatic Arthritis) study, a randomized, double-blind, two-dose trial, examined the efficacy etanercept treatment patients moderate-to-severe plaque psoriasis PsA main results have been presented previously. This analysis status, duties sick days, pre-defined endpoints PRESTA, among this patient population....

Abstract Aims To assess low-density lipoprotein cholesterol (LDL-C) treatment target attainment among myocardial infarction (MI) patients according to the European Society of Cardiology (ESC)/European Atherosclerosis (EAS) dyslipidaemia guidelines from 2011 (LDL-C &amp;lt; 1.8 mmol/L or ≥50% LDL-C reduction) and 2016 reduction). Methods results Using nationwide registers, we identified 44 890 aged 21–74 admitted for MI, 2013–17. We included those attending follow-up visits at 6–10 weeks (n =...

Endometriosis, usually considered to lie within the field of gynecologist, presents a problem for general surgeon when site disease is umbilicus. The recent increase in number reported cases seems indicate much better understanding condition. I wish report 1 case and present short summaries pathogenesis, pathologic picture, diagnosis treatment this Ninety-six from literature are chronologically. A complete bibliography appended. PATHOGENESIS varied names applied diseases grouped by Sampson...

Background: The aim of this study was to extend previous findings and determine the value prompt initiation maintenance treatment (MT) following COPD exacerbations requiring hospitalization or an emergency department (ED) visit. Patients methods: Administrative claims data (collected between January 1, 2009 June 30, 2012) from employer-sponsored commercially insured population were retrospectively used identify patients with a exacerbation resulting in ED initiating approved MT for within 30...