Abstract Saffron is consumed as food and medicine to treat several illnesses. This study elucidates the saffron effectiveness on diabetic parameters in-vitro combined with resistance exercise in-vivo . The antioxidant properties of was examined. Insulin secretion glucose uptake were examined by cultured RIN-5F L6 myotubes cells. expressions GLUT2, GLUT4 AMPKα determined Western blot. Diabetic non-diabetic male rats divided into: control, training, extract treatment, training + treatment...

Introduction: Chronic wounds represent a major health burden worldwide. It has been hypothesized that the polymicrobial nature of plays an important role in their healing process. Thus, review pathogen frequency and susceptibility patterns is necessary to provide appropriate guidelines for antimicrobial usage. Methodology: In this study, microbiota resistance both acute chronic wound patients treated at University Malaya Medical Centre, Malaysia, were compared. Wound swabs from 84 with...

The present study investigated the antioxidant capacity and total content of phenolic compounds in an ethanolic extract leaves, stems fruits ofAndrographis paniculata, a medicinal plant. activity samples was evaluated by red cell hemolysis assay, free radical scavenging superoxide dismutase activities. Folin–Ciocalteu reagent assay used to estimate extracts. Leaf extracts showed highest potential followed stem fruit with rabbit erythrocytes assays. However, A.paniculata fruit exhibited DPPH...

Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose lipid homeostasis. Meta-analyses showed that hypoadiponectinemia hyperresistinemia strongly associated with increased risk of resistance, type 2 diabetes (T2DM), metabolic syndrome (MS) cardiovascular disease. The aim this study was to propose a novel adiponectin-resistin (AR) index by taking into account both adiponectin levels povide better indicator the homeostasis disorders. In addition, resistance...

Abstract The aim of this study was to investigate the responses atherosclerosis plaque biomarkers purslane seed consumption and aerobic training in women with T2D. 196 T2D were assigned into; (1) placebo (PL), (2) training+placebo (AT + PL), 3) seeds (PS), training+purslane PS). program (2.5 g lunch 5 dinner) carried out for 16 weeks. components identified quantified by GC–MS. Blood samples withdrawn via venipuncture examine blood glucose, low-density lipoprotein (LDL), high-density (HDL),...

Increased plasma plasminogen activator inhibitor-1 (PAI-1) activity and decreased tissue (tPA) could be considered a true component of the metabolic syndrome (MetS) associated with an increased risk developing cardiovascular diseases (CVD) fibrinolytic abnormalities. The aim this study was to investigate association tPA its inhibitor PAI-1 type 2 diabetes (T2D) MetS interrelationship between PAI-1and activities antigens in Malaysian T2D normal subjects. levels tPA/PAI-1 complex as well serum...

BackgroundLantibiotics are small lanthionine-containing bacteriocins produced by lactic acid bacteria. Salivaricin 9 is a newly discovered lantibiotic Streptococcus salivarius. In this study we present the mechanism of action salivaricin and some its properties. Also developed new methods to produce purify from strain NU10. Methodology / Principal FindingsSalivaricin was found be auto-regulated when an induction assay applied finding used develop successful production system in liquid...

P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, phytochemical constituents in vitro antioxidant activity of leaf aqueous extract were investigated together with its effect on oxidative stress enzymes levels diabetic rat kidney. Results . Treatment male rats (200 400 mg/kg) for 28 consecutive days prevents increase amount lipid peroxidation (LPO) product, malondialdehyde (MDA), diminution superoxide dismutase (SOD), catalase (CAT),...

We hypothesized that C. borivilianum root, known to improve male reproductive performance, prevents impairment in characteristics, morphology and elevation of oxidative stress sperm diabetics. therefore investigated the effect aqueous root extract on these parameters diabetic rat model. (250 500 mg/kg/day) or glibenclamide (600 μg/kg/day) were administered streptozotocin (STZ)-induced rats for 28 consecutive days. At end treatment, animals sacrificed collected. Sperm count percentages...

Abstract Background A plant mixture containing indigenous Australian plants was examined for synergistic antimicrobial activity using selected test microorganisms. This study aims to investigate antibacterial activities, antioxidant potential and the content of phenolic compounds in aqueous, ethanolic peptide extracts . Methods Well diffusion, minimum inhibitory concentration (MIC) bactericidal (MBC) assays were used against four pathogenic bacteria namely Staphylococcus aureus, Escherichia...

Single nucleotide polymorphisms (SNPs) at the adiponectin and resistin loci are strongly associated with hypoadiponectinemia hyperresistinemia, which may eventually increase risk of insulin resistance, type 2 diabetes (T2DM), metabolic syndrome (MS), cardiovascular disease. Real-time PCR was used to genotype SNPs (SNP+45T>G, SNP+276G>T, SNP+639T>C, SNP+1212A>G) (SNP-420C>G SNP+299G>A) genes in 809 Malaysian men (208 controls, 174 MS without T2DM, 171 T2DM MS, 256 MS) whose ages ranged...

The incidence of non-contact knee injury was found higher in female than male and is related to the phases menstrual cycle.This raised possibility that sex-steroids are involved mechanism underlying this via affecting expression receptors for relaxin, a peptide hormone known modulate ligament laxity.Therefore, study aims investigate effect on relaxin receptor isoforms (RXFP1 & RXFP2) ligaments tendons knee.Methods: Ovariectomized adult WKY rats were treated with different doses estrogen...

The effect of V. vinifera seeds on carbohydrate metabolizing enzymes and other the liver in diabetes is currently unknown. We therefore investigated changes activity levels these following seed extract administration to diabetic rats. Methods. ethanolic (250 500 mg/kg/day) or glibenclamide (600 μg/kg/day) was administered streptozotocin-induced male rats for 28 consecutive days. At end treatment, harvested various were determined. Levels thiobarbituric acid reactive substances (TBARS)...

Wide inter-ethnic allelic variations of the Angiotensin Converting Enzyme (ACE) i nsertion-deletion (I/D) gene polymorphism were thought to be responsible for conflicting gene-diabetic nephropathy disease association worldwide. We have investigated genetic susceptibility ACE diabetic in multiethnic Malaysian population.A total 137 healthy (control) and 256 subjects recruited. The further subdivided according their status based on urinary albumin-creatinine ratio (ACR) glomerular filtration...

Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, aim this study was investigate protective role C. asiatica on hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) leaf aqueous extract for four consecutive weeks. Following sacrifice,...

Background Genetic polymorphisms of the Dipeptidyl Peptidase 4 (DPP4) gene may play a role in etiology type 2 diabetes mellitus (T2DM). This study aimed to investigate possible association single nucleotide (SNPs) DPP4 Malaysian subjects with T2DM and evaluated whether they had an effect on serum levels soluble dipeptidyl peptidase (sDPP-IV). Method Ten SNPs were genotyped by TaqMan genotyping assays 314 235 controls. Of these, 71 metabolic syndrome (MetS) excluded from subsequent analysis....

The effect of C. borivilianum root on blood glucose, glycated hemoglobin (HbAIc), insulin and lipid profile levels in diabetes mellitus are not fully understood. This study therefore investigated the above parameters oxidative stress pancreas diabetes.C. aqueous extract (250 500 mg/kg/day) was administered to streptozotocin (STZ)-induced male diabetic rats for 28 days. Body weight, HbA1c, insulin, glucose homeostasis indices were determined. Histopathological changes i.e. peroxidation (LPO)...