A5012109034- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Multisensory perception and integration
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Cardiac Arrest and Resuscitation
- Ocular Disorders and Treatments
- Respiratory Support and Mechanisms
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Tactile and Sensory Interactions
- Trauma Management and Diagnosis
- Musculoskeletal pain and rehabilitation
- Bat Biology and Ecology Studies
- Airway Management and Intubation Techniques
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine regulation and behavior
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
Université du Québec à Trois-Rivières
2014-2023
Hôpital Arnaud de Villeneuve
2022
Université de Montréal
2022
Hôpital du Sacré-Cœur de Montréal
2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2022
Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
2018
Département de Chimie Moléculaire
2007
Tel Aviv University
1989-2002
University of Lausanne
1992-1999
Mice homozygous for the barrelless ( brl ) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed “barrels” in primary somatosensory cortex. Deoxyglucose uptake demonstrated that topology cortical whisker representation is nevertheless preserved. Anterograde tracers revealed a spatial segregation thalamic afferents into individual barrel territories, and single-cell recordings temporal discrimination center from surround information. Thus, structural inputs...
Abstract The blind mole rat Spalax ehrenbergi is a subterranean rodent that shows striking behavioral, structural, and physiological adaptations to fossorial life including highly degenerated eyes optic nerves behavioral audiogram indicates high specialization for low‐frequency hearing. A 2‐deoxyglucose functional mapping of acoustically activated structures, in conjunction with Nissl/Klüver‐Barrera‐stained material, revealed typical mammalian auditory pathway some indications specialized...
PREVIOUSLY we have shown that the dorsal lateral geniculate body (LGB), which is strictly visual in sighted mammals, receives a strong auditory input naturally blind mole rat (Spalax ehrenbergi). Here show with 2-deoxyglucose technique and single-unit recordings this species initially non-degenerated cortex, as defined by its connection LGB, also activated modality. These findings suggest cross-modal compensation may occur natural consequence of degeneration sense organ.
When some infant mammals are placed outside their nest, a sequence of exploratory behavior occurs, displaying regular buildup and spread activity. This "warm-up" involves repetition movement along specific dimensions an orderly transition from one dimension to the next, with cephalocaudal recruitment body limb segments. A similar principle organization applies neurological recovery lateral hypothalamic akinesia.
Abstract The purpose of this study was to identify and compare the afferent projections primary visual cortex in intact enucleated C57BL/6 mice ZRDCT/An anophthalmic mice. Early loss sensory‐driven activity blind subjects can lead activations by haptic or auditory stimuli. This intermodal activation following onset blindness is believed arise through either unmasking already present cortical connections, sprouting novel connections enhancement connections. Studies humans have similarly...
End-tidal CO2 (EtCO2) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO2, and this could reflect variable degrees of patency.To understand the impact closure during CPR, relationship between capnogram shape, closure, delivered ventilation.This study had three parts: 1) a clinical analyzing capnograms after intubation patients with out-of-hospital cardiac arrest receiving...
Abstract The mole rat ( Spalax ehrenbergi ) is a subterranean rodent whose adaptations to its fossorial life include an extremely reduced peripheral visual system and auditory suited for the perception of vibratory stimuli. We have previously shown that in this blind dorsal lateral geniculate nucleus, primary thalamic nucleus sighted mammals, activated by In report we focus on manifestation cross‐modal compensation at cortical level. Cyto‐ myeloarchitectural analyses occipital area showed...
Previous studies have reported that visual impairment can affect the quality of life leading to mental health disorders. This study aimed investigate associations between vision impairment, depression and anxiety using a mouse model congenital blindness. We phenotyped 15 anophthalmic 17 sighted adult mice in battery tests for depression-like behaviors: open field test, elevated plus maze, coated splash forced swim test. found that: (1) Anxiety levels were significantly lower when compared...
Abstract The occipital cortex, normally visual, can be activated by auditory or somatosensory tasks in the blind. This cross‐modal compensation appears after early late onset of blindness with differences activation between and could support hypothesis a reorganization sensory pathways blind that does not occur later blindness. Using immunohistochemistry c‐Fos protein following white noise stimulus injections anterograde tracer dextran‐biotin inferior colliculus, we studied how occurrence...
Visual cortical areas are activated by auditory stimuli in blind mice. Direct heteromodal connections have been shown between the primary cortex (A1) and visual (V1), A1 secondary (V2). Auditory afferents to V2 terminate close proximity neurons that project V1, potentially constitute an effective indirect pathway V1. In this study, we injected a retrograde adenoviral vector expresses enhanced green fluorescent protein under synapsin promotor V1 biotinylated dextran amine as anterograde...
Several studies show direct connections between primary sensory cortices involved in multisensory integration. The purpose of this study is to understand the microcircuitry reciprocal visual and somatosensory cortices. laminar distribution retrogradely labeled cell bodies V1 cortex both (S1BF) outside (S1) barrel field was studied provide layer indices order determine whether are feedforward, feedback or lateral type. Single axons were reconstructed size their swellings stereologically...
Abstract Enrichment of the environment is an effective means enhancing neuronal development and plasticity but its effect on cross‐modal compensation resulting from sensory deprivation has never been investigated. The present study used c‐Fos immunohistochemistry dextran–biotin tracing to examine reorganization modalities in brain anophthalmic mutant mice (ZRDCT/An) raised either enriched or standard environments. Auditory stimulation was found elicit strong activation thalamic cortical...
Bronchti, Gilles; SchÖnenberger, Norbert; Welker, Egbert; der Loos, Hendrik Van Author Information
The long-distance corticocortical connections between visual and nonvisual sensory areas that arise from pyramidal neurons located within layer V can be considered as a subpopulation of feedback connections. purpose the present study is to determine if cortical project onto cortex (V1) constitute homogeneous population cells. Additionally, we ask whether dendritic arborization relates target, modality, hierarchical level, or laterality source area. Complete 3D reconstructions arbors...
REST[ES] is the first Canadian human taphonomic facility (HTF) dedicated to research and training relating decomposition in a northern temperate climate. The following paper outlines measures taken successfully establish, open operate this novel HTF with particular focus on: project team partnerships, location, approvals permits, infrastructure social acceptability. It intended that our experience of establishing may serve as an example help others establishment future HTFs, thus...
Abstract Background Cardiopulmonary resuscitation (CPR) decreases lung volume below the functional residual capacity and can generate intrathoracic airway closure. Conversely, large insufflations induce thoracic distension jeopardize circulation. The capnogram (CO 2 signal) obtained during continuous chest compressions reflect closure, we hypothesized here that it also indicate distension. Objectives To test whether a specific may identify CPR to assess impact of on gas exchange...
It is well established that early blindness results in behavioural adaptations. While the functional effects of visual deprivation have been researched, anatomical studies are scarce. The aim this study was to investigate whole brain structural plasticity a mouse model congenital blindness. Volumetric analyses were conducted on high-resolution MRI images and histological sections from same brains. These morphometric measurements compared between anophthalmic sighted ZRDBA mice obtained by...