A5019077741- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Hippo pathway signaling and YAP/TAZ
- Genetics and Neurodevelopmental Disorders
- PI3K/AKT/mTOR signaling in cancer
- Functional Brain Connectivity Studies
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
- Tuberous Sclerosis Complex Research
New York University
2019-2024
Brown University
2012-2020
Abstract Sensory input arrives from thalamus in cortical layer (L) 4, which outputs predominantly to superficial layers. L4 L2 thus constitutes one of the earliest feedforward networks. Despite extensive study, transformation performed by this network remains poorly understood. We use two-photon calcium imaging record neural activity L2-4 primary vibrissal somatosensory cortex (vS1) as mice perform an object localization task with two whiskers. Touch responses sparsen and become more...
Abstract Most sensory information destined for the neocortex is relayed through thalamus, where considerable transformation occurs 1,2 . One powerful means of involves interactions between excitatory thalamocortical neurons that carry data to cortex and inhibitory thalamic reticular nucleus (TRN) regulate flow those 3-6 Despite enduring recognition its importance 7-9 , understanding TRN cell types, their organization, functional properties has lagged systems they control. Here we address...
SUMMARY Sensory input arrives from thalamus in cortical layer (L) 4, which it flows predominantly to superficial layers, so that L4 L2 constitutes one of the earliest feedforward networks. Despite extensive study, transformation performed by this network remains poorly understood. We use two-photon calcium imaging L2-4 primary vibrissal somatosensory cortex (vS1) record neural activity as mice perform an object localization task with two whiskers. find touch responses sparsen but become more...
The majority of cortical synapses are local and excitatory. Local recurrent circuits could implement amplification, allowing for pattern completion other computations 1 . Cortical contain subnetworks, consisting neurons with similar receptive fields elevated connectivity relative to the network average 2,3 Understanding performed by these subnetworks during behavior has been hampered fact that encoding different types information spatially intermingled distributed over large brain volumes...