A5066999052- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Neuroendocrine regulation and behavior
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Bariatric Surgery and Outcomes
- Ion channel regulation and function
- Clinical practice guidelines implementation
- Neonatal Respiratory Health Research
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Streptococcal Infections and Treatments
- Healthcare Systems and Public Health
- Birth, Development, and Health
- Acute Myeloid Leukemia Research
- Surgical site infection prevention
- Breastfeeding Practices and Influences
- Respiratory viral infections research
- Urological Disorders and Treatments
- Neonatal and Maternal Infections
- Pregnancy and Medication Impact
- Receptor Mechanisms and Signaling
- Reproductive Health and Contraception
University of Oklahoma Health Sciences Center
2017-2025
Utah State University
2024
University of Oklahoma
2016-2024
Oklahoma City University
2016-2022
University of North Carolina at Chapel Hill
2017-2018
Duke University
2014-2015
MetroHealth Medical Center
2013-2014
Indiana University – Purdue University Indianapolis
2014
Case Western Reserve University
2014
MetroHealth
2013
Cervical ripening is often the first component of labor induction and used to facilitate softening thinning cervix in preparation for labor. Common methods cervical include both mechanical (e.g., Foley or Cook catheters) pharmacologic prostaglandins) methods. The choice method(s) should take into account patient's medical obstetric history, clinical characteristics, risk adverse effects if uterine tachysystole were occur. In this narrative review, we highlight differences between...
Little is known about the specific breastmilk components responsible for protective effects on infant obesity. Whether 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), an oxidized linoleic metabolite and activator of brown fat metabolism, present in human milk, or linked to adiposity, unknown.To examine associations between concentrations 12,13-diHOME milk adiposity.Prospective cohort study from 2015 2019, following participants birth 6 months age.Academic medical centers.Volunteer...
Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods identifying treating women at risk preterm labour are limited many still present requiring tocolytic therapy to suppress uterine contractility. The aim this study was assess utility Kv7 channel activators as potential smooth muscle (myometrium) relaxants tissues from pregnant mice women. Myometrium obtained early late lipopolysaccharide (LPS)-injected (day 15...
Implantation is a complex event demanding contributions from both embryo and endometrium. Despite advances in assisted reproduction, endometrial receptivity defects persist as barrier to successful implantation women with infertility. We previously demonstrated that maternal haploinsufficiency for the endocrine peptide adrenomedullin (AM) mice confers subfertility phenotype characterized by defective uterine sparse epithelial pinopode coverage. The strong link between AM suggested compelling...
The mechanisms that control the timing of labor have yet to be fully characterized. In a previous study, overexpression small conductance calcium-activated K(+) channel isoform 3 in transgenic mice, Kcnn3(tm1Jpad)/Kcnn3(tm1Jpad) (also known as SK3(T/T)), led compromised parturition, which indicates KCNN3 SK3) plays an important role delivery process. Based on these findings, we hypothesized SK3 expression must downregulated late pregnancy enable uterus produce forceful contractions required...
The composition and function of early life gut bacterial communities (microbiomes) have been proposed to modulate health for the long term. In addition bacteria, fungi (mycobiomes) also colonize implicated in disorders such as asthma obesity. Despite potential importance mycobiomes health, there has a lack study regarding their interkingdom interactions with bacteria during infancy. goal this was obtain more complete understanding microbial thought be relevant programming health. Breastmilk...
Exercise is recommended for postpartum health, but its impacts on breastmilk composition and offspring are understudied. To test whether the metabolome altered with (i) acute exercise and/or (ii) habitual physical activity, (iii) exercise-altered metabolites associated infant adiposity. Milk were assessed before after in association activity score two independent cohorts. Two academic medical centers. The cohort had 15 mother-infant dyads. nested case-control analysis 84 physically active...
This study investigates the prevalence of asthma and asthma-related symptoms in New Orleans inner-city schoolchildren. A cross-sectional survey 1535 elementary, middle, high schoolchildren (aged 5–18) was conducted by using International Study Asthma Allergies Childhood (ISAAC) written questionnaire. Lifetime wheezing 39.4%, lifetime 24.4%. Wheezing during previous 12 months reported 25.7% sample. Twenty-one percent respondents having one or more attacks per year, with 5.6% reporting four...
Overexpression of the small-conductance calcium-activated K(+) channel 3 (SK3) in transgenic mice compromises parturition, suggesting that SK3 plays a role pregnancy. In wild-type mouse myometrium, expression transcript and protein is significantly reduced during pregnancy, but mechanism(s) responsible for this attenuation unknown. The promoter region SK3-encoding KCNN3 gene contains two binding sites specificity (Sp) transcription factors, which are expressed uterus: Sp1, enhances response...
In late gestation, enhanced myometrial contractility is mediated in part through increased Rho/Rho kinase. Since leptin, which elevated pregnancy and obesity, can directly depress function, we hypothesized that leptin receptor-deficient mice, would be greater due to kinase activity. To test this, correlated RhoA Rho expression myometrium from nonpregnant (NP) late-pregnant (P18) heterozygous mice ( db/+) vs. wild-type (WT) mice. NP KCl-induced contractions were similar between WT db/+...
Transgenic and knockout mouse models have proven useful in the study of genes necessary for parturition—including that affect timing and/or progression labor contractions. However, taking full advantage these will require a detailed characterization contractile patterns uterus. Currently best methodology this has been measurement isometric tension isolated muscle strips vitro. does not provide real-time measure changes uterine pressure over course pregnancy. Recent advances opened...
A complex integration of molecular and electrical signals is needed to transform a quiescent uterus into contractile organ at the end pregnancy. Despite discovery key regulators uterine contractility, this process still not fully understood. Transgenic mice provide an ideal model in which study parturition. Previously, only method contractility mouse was ex vivo isometric tension recordings, are suboptimal for several reasons. The must be removed from its physiological environment, limited...
The maternal cardiovascular system undergoes hemodynamic changes during pregnancy via angiogenesis and vasodilation to ensure adequate perfusion of the placenta. Improper vascularization at maternal-fetal interface can cause complications poor fetal outcomes. Recent evidence indicates that small conductance Ca 2+ -activated K + channel subtype 3 (SK3) contributes vascular remodeling pregnancy, we hypothesized abnormal SK3 expression would alter ability adapt demands lead We investigated this...
Oxytocin is a potent uterotonic agent and used clinically for induction augmentation of labor, as well prevention treatment postpartum hemorrhage. increases uterine contractility by activating the oxytocin receptor (OXTR), member G protein-coupled family, which prone to molecular desensitization. After binding, OXTR phosphorylated kinase (GRK) allows recruitment β-arrestin, internalization, According previous in vitro analyses, desensitization calcium signaling mediated GRK6. The objective...
The prevalence of both obesity and gestational diabetes mellitus (GDM) has increased, each is associated with adverse perinatal outcomes including fetal overgrowth, neonatal morbidity, hypertensive disorders pregnancy caesarean delivery. Women GDM who are also overweight or obese have higher rates complications when compared normal-weight women GDM, which may occur in part due to suboptimal glycaemic control. current recommendations for targets pregnant based on limited evidence exceed the...
OBJECTIVE: To assess the ability of ultrasound in predicting abnormal karyotype pregnancies with prenatally diagnosed omphaloceles and to compare its test characteristics previously published studies. METHODS: A retrospective case-control study at one center was performed from 1995–2007. Cases were those an controls a normal karyotype. Data collection included demographics, results, findings. The number type associated anomalies compared between cases controls. sensitivity, specificity,...
Women with obesity have higher rates of complications following cesarean delivery, such as wound infection and endometritis, risks being the highest if a delivery is performed after labor. Previous efforts at predicting whether patient's labor course would ultimately result in been intermediate area under curve 0.75 to 78 range.This study aimed assess machine learning algorithms outperform traditional modeling developing prediction model among gravidas morbid (body mass index ≥40 kg/m2)...
Objective: We aimed to investigate prospective associations between milk bioactives related metabolic health (glucose, insulin, leptin, C reactive protein [CRP], and interleukin 6 [IL-6]) incident formula initiation at 3 months postpartum. Design: This study included 363 mother-infant dyads who were fully breastfed 1 month participated in the Mothers Infants Linked for Healthy Growth from pregnancy Associations glucose, CRP, IL-6 feeding (FF) months, respectively, tested using multiple...