A5002929730- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Cancer Research and Treatments
- Amino Acid Enzymes and Metabolism
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Metabolism and Genetic Disorders
- Reproductive Biology and Fertility
- Carcinogens and Genotoxicity Assessment
- Effects of Radiation Exposure
- Viral gastroenteritis research and epidemiology
- Animal Genetics and Reproduction
- Drug-Induced Hepatotoxicity and Protection
- T-cell and Retrovirus Studies
- Cancer, Hypoxia, and Metabolism
- Connexins and lens biology
- Epigenetics and DNA Methylation
- Carbohydrate Chemistry and Synthesis
- Respiratory viral infections research
- Proteoglycans and glycosaminoglycans research
- T-cell and B-cell Immunology
- HER2/EGFR in Cancer Research
Tohoku University
2008-2022
Kirin (United States)
2020
Kyowa Kirin (Japan)
2008-2018
Kyowa Hakko Kirin (Singapore)
2015-2018
Yokohama City University
2016
Yokohama City University Medical Center
2016
Toyama Prefectural University
2009-2010
Soai University
2009
Kyushu University
2009
Tokai University
2009
Some cases of familial amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding cytosolic, copper–zinc superoxide dismutase (<i>SOD1</i>). We report here that rats express a human <i>SOD1</i> transgene with two different ALS-associated (G93A and H46R) develop striking motor neuron degeneration paralysis. As disease transgenic ALS mice, pathological analysis demonstrates selective loss neurons spinal cords these rats. In cord tissues, this is accompanied activation...
Abstract Fibroblast growth factor (FGF)23 is proposed to play a physiological role in the regulation of phosphate and vitamin D metabolism; deranged circulatory levels FGF23 cause several diseases with abnormal mineral metabolism. This paper presents novel approach analyze mechanism action using anti-FGF23 monoclonal antibodies that can neutralize activities both vitro vivo. We developed two (FN1 FC1) recognize N- C-terminal regions FGF23, respectively. Both FN1 FC1 inhibited activity...
Adult T cell leukemia (ATL) is an aggressive neoplastic disease, in which a quarter of the patients develop opportunistic infections due to cellular immunodeficiency. However, underlying mechanism responsible for immunosuppression has remained unclear. Recent studies have demonstrated that cells from subset with ATL express Foxp3, specific marker CD25+CD4+ regulatory (Treg) cells, regulate immune response by suppressing CD4+ functions. whether there functional resemblance between Foxp3...
Since the beginning of 20th century, humans have experienced four influenza pandemics, including devastating 1918 'Spanish influenza'. Moreover, H5N1 highly pathogenic avian (HPAI) viruses are currently spreading worldwide, although they not yet efficiently transmitted among humans. While threat a global pandemic involving virus strain looms large, our mechanisms to address such catastrophe remain limited. Here, we show that pre-stimulation Toll-like receptors (TLRs) 2 and 4 increased...
d-Serine is nephrotoxic in rats. Based on circumstantial evidence, it has been suspected that d-amino-acid oxidase involved this nephrotoxicity. Since we found LEA/SENDAI rats lacked oxidase, examined whether enzyme was associated with d-serine-induced nephrotoxicity using the and control F344 When d-propargylglycine, which known to have a effect through its metabolism by injected intraperitoneally into rats, caused glucosuria polyuria. However, injection of d-propargylglycine did not cause...
Wild waterfowl are a reservoir for influenza A viruses, which can be transmitted from these birds to other animal species. Occasionally, viruses species animals than wild waterfowl, e.g. an equine virus has been dogs and caused outbreaks. To understand the molecular mechanism by adapt new species, changes involved in adaptation of H7N7 were studied mice. Mutations mouse-adapted mapped one amino acid change PA protein, PB2 two PB1. Of mutations, Glu-to-Lys substitution at position 627...
ABSTRACT Bacterial endotoxins, also known as lipopolysaccharides, are a fever-producing by-product of gram-negative bacteria commonly pyrogens. It is essential to remove endotoxins from parenteral preparations since they have multiple injurious biological activities. Because their strong heat resistance (e.g., requiring dry-heat sterilization at 250°C for 30 min) and the formation various supramolecular aggregates, depyrogenation more difficult than sterilization. We report here that soft...
Quail are thought to serve as intermediate hosts of influenza A viruses between aquatic birds and terrestrial birds, such chickens, due their high susceptibility aquatic-bird viruses, which then adapt replicate efficiently in new hosts. However, does replication quail similarly result efficient humans? Using sialic acid-galactose linkage-specific lectins, we found both avian (sialic acid-α2-3-galactose [Siaα2-3Gal] linkages on sialyloligosaccharides)--and human (Siaα2-6Gal)-type receptors...
To investigate the pathogenesis of human T lymphocyte virus type I (HTLV-I)- related diseases, env-pX gene HTLV-I was introduced into germline inbred Wistar-King-Aptekman-Hokudai rats. A wide spectrum collagen vascular diseases evident in transgenic rats, including chronic destructive arthritis similar to rheumatoid arthritis, necrotizing arteritis mimicking polyarteritis nodosa, polymyositis, myocarditis, dermatitis, and sialoadenitis dacryoadenitis resembling Sjögren's syndrome humans....
The β subunits of voltage-dependent calcium channels are known to modify channel currents through pore-forming α1 subunits. Of the four reported date, β3 subunit is highly expressed in smooth muscle cells and thought consist L-type channels. To determine role cardiovascular system situ, we performed a series experiments β3-null mice. Western blot analysis indicated significant reduction expression plasma membrane Dihydropyridine binding also revealed decrease population aorta....
Transgenic mice were generated in which a 2.2-kb segment of the 5'-flanking sequence mouse oviduct-specific glycoprotein (OGP) gene was used to drive expression simian virus 40 large T antigen (Tag). These spontaneously developed tumors female reproductive tract. Analysis using reverse transcriptase-polymerase chain reaction showed that OGP region drove Tag mRNA oviduct, uterus, vagina, and ovary, but not other tissues. Histological immunohistochemical analyses revealed tumor cells...