A5045546316- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Dental Implant Techniques and Outcomes
- Graphene research and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cellular Mechanics and Interactions
- Pancreatic and Hepatic Oncology Research
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- Advanced Fluorescence Microscopy Techniques
- Nanoplatforms for cancer theranostics
Université Paris-Saclay
2017-2022
Centre National de la Recherche Scientifique
2018-2022
Institut Galien Paris-Saclay
2017-2022
Université Paris-Sud
2017
Istituto Nanoscienze
2016
The preclinical drug screening of pancreatic cancer treatments suffers from the absence appropriate models capable to reproduce in vitro heterogeneous tumor microenvironment and its stiff desmoplasia. Driven by this pressing need, we describe paper conception characterization a novel 3D model consisting triple co-culture cells (PANC-1), fibroblasts (MRC-5) endothelial (HUVEC), which assembled form hetero-type multicellular spheroid (MCTS). By histological analyses Selective Plain...
Application of 3D multicellular tumor spheroids to the investigation polymer nanomedicines.
We recently constructed a multicellular spheroid model of pancreatic tumor based on triple co-culture cancer cells, fibroblasts and endothelial cells characterized by the presence fibronectin, an important component extracellular matrix. By combining stromal components, this recreates in vitro three-dimensional (3D) architecture solid tumors. In study, we used these hetero-type spheroids as tool to assess penetration doxorubicin (used drug) through whole mass either free form or loaded into...
Graphene-based capsules have strong potential for a number of applications, including drug/gene delivery, tissue engineering, sensors, catalysis and reactors. The ability to integrate graphene into carrier systems with three-dimensional (3D) geometry may open new perspectives both fundamental tests mechanics novel (bio)technological applications. However, the assembly 3D complexes from or its derivatives is challenging because poor stability under biological conditions. In this work, we...
Well-defined, heterotelechelic polymer prodrugs for combination therapy were synthesized by using a of the "drug-initiated" nitroxide-mediated polymerization from gemcitabine-alkoxyamine initiator and nitroxide exchange reaction TEMPO-bearing drugs to end-cap drug-polymer chain-end second drug. This methodology was successfully applied two different clinically relevant combinations, gemcitabine/doxorubicin (Gem/Dox) gemcitabine/lapatinib (Gem/Lap), showing certain degree universality...