A5100696660- Glycosylation and Glycoproteins Research
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Advanced Proteomics Techniques and Applications
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Medical Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- interferon and immune responses
- Tissue Engineering and Regenerative Medicine
- Caveolin-1 and cellular processes
- Cancer Research and Treatments
- Glaucoma and retinal disorders
- AI and HR Technologies
- Risk Perception and Management
- AI and Multimedia in Education
- Anesthesia and Neurotoxicity Research
- Phytochemical Studies and Bioactivities
- Steroid Chemistry and Biochemistry
- Acupuncture Treatment Research Studies
Georgia Institute of Technology
2023-2025
Tohoku Medical and Pharmaceutical University
2022-2025
Guangdong University of Technology
2022-2024
Heidelberg University
2023
Dalian University of Foreign Languages
2023
German Cancer Research Center
2023
Naval University of Engineering
2023
University of Cambridge
2022
Dalian University
2022
Tianjin University of Science and Technology
2013
Abstract Fms‐like tyrosine kinase‐3 (FLT3) is a commonly mutated gene in acute myeloid leukemia (AML). The two most common mutations are the internal‐tandem duplication domain (ITD) mutation and kinase (TKD) mutation. FLT3‐ITD FLT3‐TKD exhibit distinct protein stability, cellular localization, intracellular signaling. To understand underlying mechanisms, we performed proximity labeling with TurboID to identify proteins that regulate or ‐TKD differently. We found BRCA1/BRCA2‐containing...
Parental food education has been recognized among the important factors influencing children's literacy; however, intrinsic mechanisms through which this influence occurs are unclear. In study, a mediation model was constructed to explore issue, using parent-child relationship and learning motivation as mediating variables. total, 204 children, aged 9-14 years old, responded questionnaires on parental education, literacy, relationship, motivation, were used measure variables of interest. The...
Abstract The epithelial-to-mesenchymal transition (EMT) is a crucial process driving cancer metastasis. In this transition, cell morphologies and properties are dramatically changed, but the underlying molecular mechanisms remain to be explored. work, we performed comprehensive analysis of proteome, glycoproteome, surfaceome during EMT induced in A549 lung carcinoma cells using mass spectrometry-based proteomics. We identified five distinct states characterized by alterations protein...
O-GlcNAcylation plays critical roles in the regulation of protein functions and cellular activities, including interactions with other macromolecules. While formation biomolecular condensates (or biocondensates) regulated by a few individual proteins has been reported, systematic investigation on biocondensate remains to be explored. Here we systematically study regulating solubility its impacts RNA-protein using mass spectrometry-based chemoproteomics. Unexpectedly, observe system-wide...
This paper delves into the feasibility of implementing Cradle to (C2C) principles in conceptual product design achieve sustainability objectives. By developing two concept products and conducting a series qualitative quantitative experiments, this research demonstrates potential C2C approach as crucial guide process emphasizes its significance creating environmentally socially responsible products. Nevertheless, study also highlights challenges limitations associated with practical...
Abstract Monoclonal antibodies have emerged as key therapeutics, and nanobodies are rapidly gaining momentum following the approval of first nanobody drug in 2019. Nonetheless, development these biologics therapeutics remains a challenge. Despite availability established vitro directed evolution technologies that relatively fast cheap to deploy, gold standard for generating therapeutic discovery from animal immunization or patients. Immune-system derived tend favourable properties vivo,...
This study aims to investigate the changes of retinal vascular system in primary angle closure glaucoma (PACG) and acute (APAC) by optical coherence tomography (OCT) angiograph (OCTA) evaluate diagnostic ability vessel density (VD) different sectors layers optic disc macular area APAC PACG.In this cross-sectional, observational study, 21 patients (22 eyes) PACG (27 along with 17 healthy people were enrolled from August 2018 March 2019. Optic region imaged using swept-source OCTA system. VD...
Abstract The N‐termini of proteins can regulate their degradation, and the same protein with different may have distinct dynamics. Recently, it was found that N‐terminal glycine serve as a degron recognized by two E3 ligases, but also reported to stabilize proteins. Here we developed chemoenzymatic method for selective enrichment proteoforms integrated dual protease cleavage further improve specificity. Over 2000 unique peptides were analyzed from >1000 proteins, most them are previously...
Although camping as a form of leisure tourism has grown increasingly popular since the onset COVID-19 pandemic, research on factors influencing campsite selection is still limited. This study aims to explore relationship between perceived risk and selection. We constructed moderated mediation model tested whether destination image acted mediator in this association, tourists’ knowledge level indirect effect image. Three hundred twenty-five Chinese participants filled out questionnaires...
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure glycans. Fut8 widely conserved from Caenorhabditis elegans humans, its mutants have been reported in mice, zebrafish. Although show symptoms, such as spinal deformity growth retardation, effects on skeletal muscles are unknown. We aimed elucidate function muscle...
Gradient colors are widely used in product design. The variation of gradient muting a color as series steps from bright to dull creates soft and gradual impression while also affecting people's perceptions. This study manipulates the types explore relationship between gradients perception stability determine whether weight plays role. In case controlling for aesthetic differences, manipulated two (dark fading upward bottom versus downward top) measured perceptions stability. same hue, an...
Unfixed-seat tickets are one of the supplementary forms used when transport capacity high-speed rail is insufficient; however, needs passengers with unfixed-seat often neglected. To understand influence on passengers’ perception quality service, including their satisfaction, this study takes provision real-time crowding information (RTCI) as independent variable and satisfaction service dependent variable, adds social anxiety a moderating to construct model. We conducted experiments gathered...
Glycoproteins located on the cell surface play a pivotal role in nearly every extracellular activity. N-glycosylation is one of most common and important protein modifications eukaryotic cells, it often regulates folding trafficking. Glycosylation cell-surface proteins undergoes meticulous regulation by various enzymes endoplasmic reticulum (ER) Golgi, ensuring their proper trafficking to surface. However, impacts N-glycosylation, N-glycan maturity, status glycoproteins remain be explored....
With the wide application of big data technology, various management information systems in colleges and universities have accumulated a large amount data. The use mining technology teaching can make full these effectively improve to certain extent. purpose this paper is study construction an intelligent student system platform based on analysis. This documents performance system, example collection according process. interface will be seen by teachers, students supervisors friendly way,...
Objective To explore the effect of doctor-nurse-patient integrated nuring mode in promoting high quality care obstetrical department. Methods A total 132 cases primipara from June to July 2014 were taken as control group, and given traditional fragmented obstetric health model. A 136 March April 2015 study adopted nursing mode.The primipara's satisfaction for nursing, doctors' nurses' self-satisfaction before after implementation compared.Meanwhile, primiparae's body weight control,...
Under the background of engineering, in order to achieve teaching goal “Cultivate people with virtue”, ideological and political construction engineering courses pays more attention strengthening students’ ethics education, cultivating spirit striving for excellence as a great country craftsman, stimulating feelings mission serving science technology, so that help students get better knowledge skills. The paper takes course circuit an example, organically integrates elements curriculum into...
<div>Abstract<p>Dissociation from epithelial sheets and invasion through the surrounding stroma are critical early events during cancer metastasis. Here we find that a lymphocyte lineage–restricted transcription factor, Spi-B, is frequently expressed in human lung tissues. The Spi-B–expressing cells coexpressed vimentin but repressed E-cadherin exhibited invasive behavior. Increased Spi-B expression was associated with tumor grade, lymphatic metastasis, short overall survival....
<p>Table S2, related to Figure 4: Genes downregulated/upregulated >2-fold by Spi-B transient expression in A549 cells</p>
<p>Figure S1, related to Figure 3. Effect of Spi-B on EMT. (A) Phase-contrast micrographs HBECs expressing vector or Spi-B. Scale bars are 100μm; (B) western blot showed expression Spi-B, E-cadherin, Vimentin and Actin; (C) Quantitative RT-PCR assay for Snail1, Snail2, Twist1 ZEB1. S2, H526 cells control shRNAs. 50μm; BrdU in corporation A549 Spi-B; Spi-B-expressing were plated fibronectin-coated plates. After 15 min, attached counted. represent 200 mm. Bar graph below shows number...
<p>Table S3, related to Figure 4: List of Spi-B-dependent genes categorized by biological function.</p>