Background Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In patients, skeletal muscle wasting, mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6), the presence acute phase response. Acute proteins, including fibrinogen amyloid A (SAA) synthesized by hepatocytes IL-6 as part innate immune To gain insight into relationships among these observations, we...

The cupin superfamily is a group of functionally diverse proteins that are found in all three kingdoms life, Archaea, Eubacteria, and Eukaryota. These have characteristic signature domain comprising two histidine- containing motifs separated by an intermotif region variable length. This consists six beta strands within conserved barrel structure. Most cupins, such as microbial phosphomannose isomerases (PMIs), AraC- type transcriptional regulators, cereal oxalate oxidases (OXOs), contain...

MicroRNAs are non-coding RNAs that regulate gene expression including differentiation and development by either inhibiting translation or inducing target degradation. The aim of this study is to determine the microRNA signature during human pancreatic identify potential targets calculating correlations between microRNAs their corresponding mRNA targets, predicted bioinformatics, in genome-wide RNA microarray study.The fetal samples 10-22 weeks gestational age (wga), was obtained PCR-based...

Minimum dominating sets (MDSet) of protein interaction networks allow the control underlying through their topological placement. While essential proteins are enriched in MDSets, we hypothesize that statistical properties biological functions genes enhanced when focus on MDSet (e-MDSet). Here, determined minimum E. coli, S. cerevisiae and H. sapiens, defined as subsets whereby each remaining can be reached by a single interaction. We compared several functional parameters essential, MDSet,...

Summary We have compiled two comprehensive gene expression profiles from mature leaf and immature seed tissue of rice ( Oryza sativa ssp. japonica cultivar Nipponbare) using Serial Analysis Gene Expression (SAGE) technology. revealed a total 50 519 SAGE tags, corresponding to 15 131 unique transcripts. Of these, the large majority (∼70%) occur only once in both libraries. Unexpectedly, most abundant transcript (∼3% total) library was derived type 3 metallothionein gene. The overall frequency...

Journal Article Investigations into the Role of Sucrose in Potato cv. Estima Microtuber Production vitro Get access S. Khuri, Khuri Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Moorby Annals Botany, Volume 75, Issue 3, March 1995, Pages 295–303, https://doi.org/10.1006/anbo.1995.1024 Published: 01 1995

Myzus persicae, the green peach aphid, is a polyphagous herbivore that feeds from hundreds of species mostly dicot crop plants. Like other phloem-feeding aphids, M. persicae rely on endosymbiotic bacterium, Buchnera aphidicola (Buchnera Mp), for biosynthesis essential amino acids and nutrients are not sufficiently abundant in their phloem sap diet. Tobacco-specialized typically red somewhat distinct lineages this species. To determine whether bacteria could play role tobacco adaptation, we...

The neurotransmitter L-Glutamate (L-Glu) acting at ionotropic L-Glu receptors (iGluR) conveys fast excitatory signal transmission in the nervous systems of all animals. iGluR-dependent neurotransmission is a key component synaptic plasticity that underlies learning and memory. During learning, two subtypes iGluR, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPAR) N-methyl-D-aspartate (NMDAR), are dynamically regulated postsynaptically vertebrates. Invertebrate organisms such as...

Glucose is a simple sugar that plays an essential role in many basic metabolic and signaling pathways. Many proteins have binding sites are highly specific to glucose. The exponential increase of genomic data has revealed the identity seem be central biological processes, but whose exact functions unknown. these associated with disease processes. Being able predict glucose-specific will greatly enhance our ability annotate protein function may significantly contribute drug design. We hereby...

Summary Rare mutations in more than 20 genes have been suggested to cause dilated cardiomyopathy (DCM), but explain only a small percentage of cases, mainly familial forms. We hypothesised that common variants may also play role increasing genetic susceptibility DCM, similar observed other complex disorders. To test this hypothesis, we performed case‐control analyses on all DNA polymorphic variation identified resequencing study six candidate DCM ( CSRP3 , LDB3 MYH7, SCN5A TCAP and TNNT2 )...

Conotoxin has been proven to be effective in drug design and could used treat various disorders such as schizophrenia, neuromuscular chronic pain. With the rapidly growing interest conotoxin, accurate conotoxin superfamily classification tools are desirable systematize increasing number of newly discovered sequences structures. However, despite significance extensive experimental investigations on those have not intensively explored.In this paper, we propose consider suboptimal alignments...

Abstract Coniferous forests are an important component of the Lebanese landscape. Ten species conifers in five genera found as wild populations Lebanon: Cilician fir Abies cilicica , cedar Lebanon Cedrus libani Mediterranean Cyprus Cupressus sempervirens Syrian juniper Juniperus drupacea Grecian J. excelsa willdenow foetidissima prickly oxycedrus Calabrian pine Pinus brutia Aleppo P. halepensis and stone pinea. Although none these seriously threatened a global context, they exist mostly...

Nucleosomes are the basic structural units of eukaryotic chromatin, and they play a significant role in regulating gene expression. Specific DNA sequence patterns known, from empirical theoretical studies, to influence bending flexibility, have been shown exclude nucleosomes. A whole genome localization these patterns, their analysis, can add important insights on regulation mechanisms that depend upon structure chromatin around gene.A annotation for nucleosome exclusion regions (NXRegions)...

Production of taro [ Colocasia esculenta (L.) Schott], a tropical root crop, is declining in many areas the world as result spread diseases such Taro leaf blight (TLB). cv. Bun Long was transformed through Agrobacterium tumefaciens with oxalate oxidase (OxO) gene gf2.8 from wheat ( Triticum aestivum ). Insertion this confirmed by polymerase chain reaction (PCR) and Southern blot analysis. One independent line contained one insertion (g5), whereas second four copies gene. Reverse...

Histone deacetylases (HDACs) are the proteins responsible for removing acetyl group from lysine residues of core histones in chromosomes, a crucial component gene regulation. Eleven known HDACs exist humans and most other vertebrates. While basic function has been well characterized new discoveries still being made, transcriptional regulation their corresponding genes is poorly understood. Here, we conducted computational analysis eleven HDAC promoter sequences 25 vertebrate species to...

The functions of roughly a third all proteins in

The investigation of host-pathogen interaction interfaces and their constituent factors is crucial for our understanding an organism's pathogenesis. Here, we explored the interactomes HIV, hepatitis C virus, influenza A human papillomavirus, herpes simplex vaccinia virus in a host by analyzing combined sets targets genes that are required viral infection. We also considered bacteriophages lambda T7 infection Escherichia coli. found targeted proteins immediate network neighbors significantly...