Stella Marbot
A5058811394- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Cardiac and Coronary Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Medical Coding and Health Information
- Coronary Interventions and Diagnostics
- Antimicrobial Resistance in Staphylococcus
University Hospital of Basel
2017-2022
University of Basel
2017-2022
Cardiovascular Institute Hospital
2017
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
Abstract BACKGROUND Clinical performance of the novel high-sensitivity cardiac troponin I (Siemens-hs-cTnI-Centaur) assay is unknown. We aimed to clinically validate Siemens-hs-cTnI-Centaur and develop 0/1-h 0/2-h algorithms. METHODS enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists including all clinical information twice: first, using serial hs-cTnT...
We aimed to evaluate the impact of age on performance European Society Cardiology (ESC) 0/1h-algorithms and derive externally validate alternative cut-offs specific older patients.We prospectively enrolled patients presenting emergency department (ED) with symptoms suggestive acute myocardial infarction in three large diagnostic studies. Final diagnoses were adjudicated by two independent cardiologists. High-sensitivity cardiac troponin (hs-cTn) T I concentrations measured at presentation...
Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE incompletely understood.
Abstract BACKGROUND This study aimed to prospectively advance a rule-out strategy for functionally significant coronary artery disease (CAD) by use of high-sensitivity cardiac troponin I (hs-cTnI) from bench bedside, application 3-step approach: validation in serum, correlation plasma, and on clinical platform. METHODS Patients without known CAD referred rest/stress myocardial perfusion single-photon emission tomography/computer tomography (MPI-SPECT/CT) were assigned 3 consecutive cohorts:...
Abstract Background Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence outcome PMI using hs-cTnI, compare it hs-cTnT. Methods prospectively included 2455 patients at high cardiovascular risk undergoing 3111 surgeries, for whom hs-cTnI hs-cTnT concentrations were measured before surgery on postoperative days 1 2. was defined as...
Abstract Background In order to differentiate perioperative myocardial infarction/injury (PMI) after non-cardiac surgery from preexisting cardiomyocyte injury chronic disorders, recent studies have shown the importance of using an acute absolute increase as a criterion for PMI. For high-sensitivity troponin T (hs-cTnT), PMI defined 14ng/L (the 99th percentile) has been be strongly associated with 30-day mortality. Until now, no data on hs-cTnI are available. This is major unmet clinical...
Abstract Background Perioperative myocardial injuries (PMI) are a common complication following non-cardiac surgery associated with significantly increased postoperative mortality. Due to its mostly asymptomatic presentation it is currently often missed in clinical routine. With the advent of routine screening PMI will be an increasingly recognised. Therefore, more detailed understanding different etiologies causing needed guide management. Methods We included consecutive high-risk patients...