A5077175489- Antimicrobial Peptides and Activities
- Graphene and Nanomaterials Applications
- Immune Response and Inflammation
- Bacterial biofilms and quorum sensing
- Pediatric health and respiratory diseases
- Medicinal Plants and Neuroprotection
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Oral microbiology and periodontitis research
- Nanoparticles: synthesis and applications
- Medical and Biological Ozone Research
- Bacteriophages and microbial interactions
Museum of Heilongjiang Province
2021
Alabama State University
2015-2017
Resistance of food borne pathogens such as Salmonella to existing antibiotics is grave concern. Silver coated single walled carbon nanotubes (SWCNTs-Ag) have broad-spectrum antibacterial activity and may be a good treatment alternative. However, toxicity human cells due their physico-chemical properties serious public health Although pegylation commonly used reduce metal nanoparticle toxicity, SWCNTs-Ag not been pegylated yet, the effect on anti-bacterial cell cytotoxicity remains studied....
Abstract: The antimicrobial activity of silver-coated carbon nanotubes (AgCNTs) and their potential mode action against mucoid nonmucoid strains Pseudomonas aeruginosa was investigated in vitro. results showed that AgCNTs exhibited both with minimum inhibitory concentrations approximately 8 µg/mL, indicating a high sensitivity P. to AgCNTs. were also bactericidal at the same concentration. Scanning transmission electron-microscopy studies further revealed majority cells treated transformed...
Pseudomonas aeruginosa infection induces vigorous inflammatory mediators secreted by epithelial cells, which do not necessarily eradicate the pathogen. Nonetheless, it reduces lung function due to significant airway damage, most importantly in cystic fibrosis patients. Recently, we published that TP359, a proprietary cationic peptide had potent bactericidal effects against P. aeruginosa, were mediated down-regulating its outer membrane biogenesis genes. Herein, hypothesized TP359 could also...
Antimicrobial peptides (AMPs) are a class of antimicrobial agents with broad-spectrum activities. Several reports indicate that cationic AMPs bind to the negatively charged bacterial membrane causing depolarization and damage. However, damage may be insufficient elicit cell death, thereby suggesting other mechanism(s) action could involved in this phenomenon. In study, we investigated activity novel peptide, TP359, against two strains Pseudomonas aeruginosa, as well its possible mechanisms...
Differential gene expression levels of selected genes for the mucoid and non-mucoid strains P. aeruginosa exposed to TP359 bactericidal treatment. at 1 × 109 CFU/mL were either untreated as control, or treated with 4× MIC then grown 10 30 min. Total RNA was extracted, quantified before cDNA synthesis using reverse transcriptase, followed by PCR amplification. Data obtained from three-independent experiments used analyze relative 2-ΔΔCt method. Panels A B show 30 min treatment strain strain,...
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