Ricardo Corral
A5050631604- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Tryptophan and brain disorders
- Treatment of Major Depression
- Mental Health Treatment and Access
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- Psychological Treatments and Disorders
- Long-Term Effects of COVID-19
- Mental Health and Psychiatry
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Psychology Research and Bibliometrics
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Digital Mental Health Interventions
- Aging and Gerontology Research
- Child Nutrition and Feeding Issues
- Statistical Methods in Epidemiology
- Employment and Welfare Studies
- Healthcare Decision-Making and Restraints
- Delphi Technique in Research
- Resilience and Mental Health
Hospital Borda
2016-2025
University of Buenos Aires
2018-2025
Asociación Psicoanalítica de Buenos Aires
2021-2024
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2015-2023
Universidad Nacional de Córdoba
2023
Osakidetza
2021
Arab American Pharmacist Association
2019
Instituto de Neurología de Buenos Aires
2013
Instituto de Neurología Cognitiva
2010
The objective of this international, 8-week, randomized, double-blind study was to show the superiority antidepressant efficacy agomelatine, first MT1/MT2 receptor agonist and 5-HT2C antagonist antidepressant, versus fluoxetine in outpatients fulfilling Diagnostic Statistical Manual Mental Disorders-volume IV-TR criteria for major depressive disorder severe intensity, defined by a baseline Hamilton Depression Rating Scale (HAM-D17) total score at least 25 CGI severity illness 4. Patients...
Objective The aim of this real-world study was to evaluate the effect agomelatine on anhedonia as primary endpoint in outpatients under treatment major depressive episodes. Methods an open-label, multicenter, 8-week phase IV trial. Two hundred fifty-seven (257) patients were recruited, and 143 included analysis. Agomelatine administered orally a 25-mg tablet. dose could be increased 50 mg after 2 weeks treatment. Results An improvement severity (Snaith-Hamilton Pleasure Scale total score)...
A large proportion of patients with major depressive disorder (MDD) have treatment-resistant depression (TRD). The TRAL study examines the impact TRD on suicidality and health-related quality life (HRQoL) among MDD in 4 Latin American countries.In this multicenter, prospective, observational study, were recruited from 33 sites Mexico, Colombia, Brazil, Argentina. Patients assessed for TRD, defined as failure to respond ≥2 antidepressant medications adequate dose duration. Other assessments...
Abstract Background The prevalence of medical illnesses is high among patients with psychiatric disorders. current study aimed to investigate multi-comorbidity in disorders comparison the general population. Secondary aims were factors associated metabolic syndrome and treatment appropriateness mental Methods sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). analysis was based on registration previous history that could...
Metabotropic glutamate receptor 5 (mGluR5) is involved in cocaine reward processing and addiction. Preclinical studies suggest that blocking this inhibits self-administration seeking behavior rodents. We assessed a selective noncompetitive antagonist of mGluR5 called mavoglurant phase 2 randomized, placebo-controlled clinical trial 68 adults with use disorder. Study participants were randomly assigned 1:1 ratio to an up-titrating schedule oral twice daily up 200 mg for 98 days or placebo....
Background: Generic health-related quality of life (HRQoL) scales are increasingly being used to assess the effects new treatments in schizophrenia. The objective this study is better understand usefulness generic and condition specific HRQoL schizophrenia by analyzing their correlates. Methods: Data formed part Pattern study, an international observational among 1379 outpatients with Patients were evaluated Mini International Neuropsychiatric Inventory, Clinical Global...
Artículo de revisiónEl litio es un metal alcalino, usado hace más 60 años en psiquiatría, y actualmente considerado el estándar oro tratamiento del trastorno bipolar (TB). De acuerdo con la evidencia reciente, este principio activo útil para amplio espectro variedades clínicas los trastornos afectivos. Además, se estima que desde tiempo reduce riesgo suicidio comportamiento suicida personas estado ánimo. Por otro lado, algunos estudios novedosos han demostrado catión posee una potencial...
Agomelatine, has been shown to be effective and well-tolerated, in treating: major depressive disorder, anxiety symptoms of depression (1,2) Generalized Anxiety Disorder (3,4). The present analysis evaluate the antidepressant efficacy agomelatine more anxious elderly depressed patients ≥ 65 years, based on a score HAMD combined items 10 11 5 at baseline. In this 8-week international double-blind randomized study, among 222 out-patients randomized, 119 were anxious: 82 25-50 mg group 37...
Treatment resistant depression (TRD) is one of the most pressing issues in mental healthcare LatAm. However, clinical data and outcomes standard care (SOC) are scarce. The present study reported on Treatment-Resistant Depression America Latina (TRAL) project 1-year follow-up patients under SOC assessing presentation outcomes.
The Third Argentine Consensus on the management of bipolar disorders (TB) is an initiative Association Biological Psychiatry (AAPB). As a reference document, this consensus pursues two main objectives: one hand, to summarize and systematize best available evidence comprehensive pathology; other, provide useful, up-to-date instrument for psychiatrists, multidisciplinary teams dedicated mental health, government agencies. During period approximately six months work -that is, from May October...
Schizophrenia is a brain disconnection syndrome involving abnormal interactions between widespread networks.Genetic and non-genetic mechanisms are thought to interact affecting the developing resulting in predisposition suffer schizophrenia.We did review of current data research emphasizing on white matter abnormalities mainly punctual axonal disorganization many pathways reduction total number neurons different parts brain, brainstem and/or cerebellum.Finally we consider: (i) hypoactivation...
Approximately 30% of people with schizophrenia fail to respond first-line antipsychotic treatment which impacts the burden disease. Treatment resistant denotes patients failure at least twoadequate trials different antipsychotics. Clozapine is a unique drug approved for treating treatment-resistant schizophrenia, however 1/3 clozapine. Even though strategies have been proposed clozapine-resistant evidence very limited, unclear, and poor quality. A formal literature search was conducted then,...