A5067961111- Pluripotent Stem Cells Research
- Urticaria and Related Conditions
- Reproductive tract infections research
- Autoimmune Bullous Skin Diseases
- COVID-19 and healthcare impacts
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Cardiac Imaging and Diagnostics
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Healthcare cost, quality, practices
- Coronary Interventions and Diagnostics
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- CRISPR and Genetic Engineering
- Systemic Sclerosis and Related Diseases
- Atrial Fibrillation Management and Outcomes
- Zebrafish Biomedical Research Applications
- Epigenetics and DNA Methylation
- Cardiac tumors and thrombi
- Electronic Health Records Systems
- Otitis Media and Relapsing Polychondritis
MRC Weatherall Institute of Molecular Medicine
2016-2022
University of Oxford
2016-2022
Addenbrooke's Hospital
2021
Oxford University Hospitals NHS Trust
2013-2020
Cambridge University Hospitals NHS Foundation Trust
2020
John Radcliffe Hospital
2016-2018
Churchill Hospital
2013-2014
ABB (Sweden)
2013
China Post (China)
2013
Korea Telecom (South Korea)
2013
Delivery of every aspect care by all clinical and non-clinical departments in the UK's NHS is being reassessed fundamentally reorganised expectation an imminent surge patients with covid-19. 1Modelling outbreak assumes infection fatality ratio 0.9% a hospital admission rate 4.4%, 30% those admitted requiring critical or extracorporeal membrane oxygenation. 2 3The increased demand on healthcare services will be compounded apparent risk among workers, 4 staff absences because illness...
The threat to health of the COVID-19 infection (caused by novel zoonotic SARS-CoV-2 coronavirus) is now established.1, 2 As widespread community transmission becomes likely, it necessary urgently consider unique impact this may have on haematology patients and practical steps that can be taken reduce their risk during ongoing care. importance personal hygiene, use protective equipment investigation, isolation treatment infected are well documented elsewhere...
Abstract The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, most common single gene disorders. Here, we address mechanisms regulating embryonically α-like globin, termed ζ-globin. We show that in embryonic erythroid cells, ζ-gene lies within a ~65 kb sub-TAD (topologically associating domain) open, acetylated chromatin interacts with α-globin...
Since<i>Mycobacterium marinum (balnei)</i>infection in man was first described by Linnell and Norden,<sup>1</sup>numerous cases have been reported, usually the form of swimming pool granuloma.<sup>2</sup>The disease has also as a generalized infection immunocompromised hosts.<sup>3,4</sup>We present case cutaneous<i>M marinum</i>in an immunologically normal infant. <h3>Report Case</h3> A 16-month-old girl seen at University Michigan Hospital, Ann Arbor, with two-month history "pimplelike"...
#### Key points Neutropenic sepsis is a medical emergency in which broad-spectrum antibiotics must be given without delay In total, 75% of hospital patients do not receive their within the 1 h target door-to-needle time The typical presenting features can blunted or
The study of cellular processes and gene regulation in terminal erythroid development has been greatly facilitated by the generation an immortalised cell line derived from Human Umbilical Derived Erythroid Precursors, termed HUDEP-2 cells. ability to efficiently genome edit cells make clonal lines hugely expands their utility as insertion clinically relevant mutations allows potentially every genetic disease affecting red blood development. Additionally, sequences encoding short protein tags...
This report describes the evolution of electronic clinical decision support system (CDSS) and feedback methods at our center challenges lessons learned. The blood product order with integrated CDSS ensures collection data regarding patient's condition justification for order. An alert is generated in real time if placed outside agreed guidelines. We have provided several ways. began monthly review meetings junior hematology clinicians responsible ordering blood. was successful reducing...
Mouse embryonic stem cells (mESCs) can be manipulated in vitro to recapitulate the process of erythropoiesis, during which multipotent undergo lineage specification, differentiation and maturation produce erythroid cells. Although useful for identifying specific progenitors precursors, this system has not been fully exploited as a source analyse erythropoiesis. Here, we establish protocol characterised erythroblasts isolated scalable manner from differentiated embryoid bodies (EBs). Using...
The subject of the treatment gonorrhoea by high fever mechanically produced is
ABSTRACT Genome-wide association studies (GWAS) have identified over 150,000 links between common genetic variants and human traits or complex diseases. Over 80% of these associations map to polymorphisms in non-coding DNA. Therefore, the challenge is identify disease-causing variants, genes they affect, cells which effects occur. We developed a platform using ATAC-seq, DNaseI footprints, NG Capture-C machine learning address this challenge. Applying approach red blood cell identifies...
Background Rarely, healthy donors fail adequate peripheral blood stem cell ( PBSC ) mobilization. If the recipient has already received conditioning chemotherapy, this can result in donor undergoing urgent marrow harvest under general anesthesia. Plerixafor is a novel CXCR 4 antagonist, licensed for autologous PBSCH patients who failed mobilization with granulocyte–colony‐stimulating factor G ‐ CSF alone. Experience using plerixafor allogeneic failing scarce. Case Report A 65‐year‐old...
Research Articles| January 15 2010 Non-Gonococcal Urethritis and Trichomoniasis in the Male Subject Area: Further Areas A.J. King London, England Search for other works by this author on: This Site PubMed Google Scholar Urol Int (1959) 9 (3-6): 127–145. https://doi.org/10.1159/000277449 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Get Permissions Cite Citation King; Male....
Case ReportA 56-year-old woman with acute myeloid leukemia was admitted to our unit in January 2010 for her second cycle of chemotherapy daunorubicin and cytarabine.Before diagnosis, she had no medical problems.At found have an incidental factor VII deficiency.Her bone marrow karyotype normal, activating mutation FMS-like tyrosine kinase 3 (FLT3).She enrolled onto the (AML) 17 trial randomly assigned receive cytarabine kinase-3 inhibitor, lestaurtinib.The first complicated by neutropenic...