A5044309729- Traumatic Brain Injury and Neurovascular Disturbances
- 3D Printing in Biomedical Research
- Barrier Structure and Function Studies
- Advanced Neuroimaging Techniques and Applications
- Cell Image Analysis Techniques
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Blood properties and coagulation
- Advanced MRI Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Mathematical Biology Tumor Growth
- Tree-ring climate responses
- Tensor decomposition and applications
- Lattice Boltzmann Simulation Studies
- Lipid metabolism and disorders
- Cellular Mechanics and Interactions
- Medical Image Segmentation Techniques
- Neuroscience and Neural Engineering
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- NMR spectroscopy and applications
University College London
2020-2024
Institut de Mécanique des Fluides de Toulouse
2016-2024
Université de Toulouse
2017-2024
Centre National de la Recherche Scientifique
2017-2024
Nerve Centre
2020-2023
Institut National Polytechnique de Toulouse
2016-2020
École Nationale Supérieure d'Électrotechnique, d'Électronique, d'Informatique, d'Hydraulique et des Télécommunications
2016-2020
Université Toulouse III - Paul Sabatier
2017
Despite the key role of capillaries in neurovascular function, a thorough characterization cerebral capillary network properties is currently lacking. Here, we define range metrics (geometrical, topological, flow, mass transfer, and robustness) for quantification structural differences between brain areas, organs, species, or patient populations and, parallel, digitally generate synthetic networks that replicate organizational features anatomical (isotropy, connectedness, space-filling...
Structural changes to microvascular networks are increasingly highlighted as markers of pathogenesis in a wide range disease, e.g. Alzheimer's vascular dementia and tumour growth. This has motivated the development dedicated 3D imaging techniques, alongside creation computational modelling frameworks capable using reconstructed simulate functional behaviours such blood flow or transport processes. Extraction from data broadly consists two image processing steps: segmentation followed by...
The physics of blood flow in small vessel networks is dominated by the interactions between Red Blood Cells (RBCs), plasma and walls. resulting couplings microvessel network architecture heterogeneous distribution RBCs at network-scale are still poorly understood. main goal this paper to elucidate how a local effect, such as RBC partitioning individual bifurcations, interacts with global structure field induce specific preferential locations model microfluidic networks. First, using...
ABSTRACT Structural changes to microvascular networks are increasingly highlighted as markers of pathogenesis in a wide range disease, e.g. Alzheimer’s vascular dementia and tumour growth. This has motivated the development dedicated 3D imaging techniques, alongside creation computational modelling frameworks capable using reconstructed simulate functional behaviours such blood flow or transport processes. Extraction from data broadly consists two image processing steps: segmentation...
Abstract Recent studies have explored the potential of tissue‐mimetic scaffolds in encouraging nerve regeneration. One major determinants regenerative success cellular repair constructs (NRCs) is local microenvironment, particularly native low oxygen conditions which can affect implanted cell survival and functional performance. In vivo, cells reside a range environmental due to spatial gradients nutrient concentrations that are established. Here we evaluate vitro differences behavior such...
Millions of people worldwide are affected by peripheral nerve injuries (PNI), involving billions dollars in healthcare costs. Common outcomes for patients include paralysis and loss sensation, often leading to lifelong pain disability. Engineered Neural Tissue (EngNT) is being developed as an alternative the current treatments large-gap PNIs that show underwhelming functional recovery many cases. EngNT repair constructs composed a stabilised hydrogel cylinder, surrounded sheath material,...
Recent progresses in intravital imaging have enabled highly-resolved measurements of periarteriolar oxygen gradients (POGs) within the brain parenchyma. POGs are increasingly used as proxies to estimate local baseline consumption, which is a hallmark cell activity. However, profile around given arteriole arises from an interplay between consumption and delivery, not only by this but also distant capillaries. Integrating such interactions across scales while accounting for complex...
Cellular engineered neural tissues have significant potential to improve peripheral nerve repair strategies. Traditional approaches depend on quantifying tissue behaviours using experiments in isolation, presenting a challenge for an overarching framework design. By comparison, mathematical cell-solute models benchmarked against experimental data enable computational be performed test the role of biological/biophysical mechanisms, as well explore impact different design scenarios and thus...
Abstract The existence of cerebral blood flow (CBF) reductions in Alzheimer’s disease (AD) patients and related mouse models has been known for decades, but the underlying mechanisms resulting impacts on cognitive function AD pathogenesis remain poorly understood. In APP/PS1 model we found that an increased number cortical capillaries had stalled as compared to wildtype animals, largely due leukocytes adhered capillary segments blocked flow. These stalls were early feature development,...
Around 5% of all traumas result in Peripheral Nerve Injuries (PNI). More than one million people per year are affected Europe and the USA (Chen et al. 2015), healthcare costs estimated t...
Abstract The xylem network, the water conduction system in wood determines ability of trees to avoid hydraulic failure during drought stress. capability withstand embolisms, disruptions column by gas bubbles that contribute failure, is mainly determined anatomical arrangement and connectedness (topology) vessels. However, quantification network characteristics has been difficult, so relating properties topology vulnerability predicting function remains challenging. We studied vessel networks...