A5055057189- Hepatitis B Virus Studies
- Hepatitis C virus research
- Neuropeptides and Animal Physiology
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Hepatitis Viruses Studies and Epidemiology
- Pneumonia and Respiratory Infections
- Receptor Mechanisms and Signaling
- Wheat and Barley Genetics and Pathology
- Regulation of Appetite and Obesity
- Hemoglobinopathies and Related Disorders
- Evolution and Genetic Dynamics
- Escherichia coli research studies
- Trauma and Emergency Care Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Genetics and Biotechnology
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Trauma Management and Diagnosis
- HIV Research and Treatment
- Bacterial Infections and Vaccines
- Immunotherapy and Immune Responses
Johns Hopkins University
2013-2018
Bloomberg (United States)
2017
Children's Hospital of Philadelphia
2011-2013
California University of Pennsylvania
2013
Eastern Virginia Medical School
1980
ABSTRACT Competence for genetic transformation in Streptococcus pneumoniae develops response to accumulation of a secreted peptide pheromone and was one the initial examples bacterial quorum sensing. Activation this signaling system induces not only expression proteins required but also production cellular chaperones proteases. We have shown here that activity pathway is sensitively responsive changes accuracy protein synthesis are triggered by either mutations ribosomal or exposure...
The appearance of new mutations within a population provides the raw material for evolution. consistent decline in fitness observed classical mutation accumulation studies has provided support long-held view that deleterious are more common than beneficial mutations. Here we present results study using design with bacterium Streptococcus pneumoniae which derived populations increased. This rise was associated specifically adaptation to survival during brief stationary phase periods between...
Competence for genetic transformation in Streptococcus pneumoniae has previously been described as a quorum-sensing trait regulated by secreted peptide pheromone. Recently we demonstrated that competence is also activated reduction the accuracy of protein biosynthesis. We have now investigated whether errors upstream translation form random genomic mutations can provide similar stimulus. Here show generation mutator phenotype S. through deletions mutX, hexA or hexB enhanced expression...
Untreated chronic hepatitis B can lead to liver failure and/or cancer. These complications be avoided through prevention with vaccination or treatment of disease. To inform health policy for the Tibetan community in India, we conducted study prevalence and needs. We a cross-sectional over 3 months 2013. Households were randomly selected participation via satellite map; one boarding school residential monastery also included. Participants asked questions whole blood sample was collected HBsAg...
Abstract Human genetic studies demonstrate a link between the 32‐bp deletion that produces nonfunctional CCR5 receptor and enhanced recovery from acute hepatitis B virus (HBV) infection. To investigate role of in immune responses to HBV, we intravenously infected Ccr5 +/+ (WT) −/− (KO) mice with replication‐incompetent adenovirus containing overlapping HBV1.3 construct (AdHBV), or vector control. At day 3 following AdHBV infection, analysis intrahepatic leukocytes (IHL) showed KO had...
Abstract Human genetic studies demonstrate that a non-functional CCR5 receptor sequence variant is associated with enhanced control of acute hepatitis B virus (HBV) infection. To better understand the role in immune responses to HBV, we employed mouse model HBV which Ccr5 +/+(WT) or −/−(KO) C57BL/6 mice were intravenously infected adenovirus containing an overlapping HBV1.3 construct (AdHBV) vector (AdShuttle). Mice (N=4–6/group) euthanized at days 2, 3, 7, 10, and 14 post injection....