A5050369503- Immune cells in cancer
- Prostate Cancer Treatment and Research
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Inflammation biomarkers and pathways
- Eosinophilic Disorders and Syndromes
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Mechanisms of cancer metastasis
- Systemic Lupus Erythematosus Research
- Drug-Induced Adverse Reactions
- Uterine Myomas and Treatments
- Cutaneous lymphoproliferative disorders research
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Complement system in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Tuberous Sclerosis Complex Research
- Contact Dermatitis and Allergies
- Cancer Genomics and Diagnostics
University of Rochester Medical Center
2016-2022
Clinical Research Management
2022
University of Rochester
2012-2021
University of California, San Diego
2012
Abstract Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer other malignancies. Although have the ability to suppress T-cell function, little known about direct impact these innate on tumor growth. Here, it reported that suppressor (MDSC) are predominant tumor-infiltrating xenografts established athymic nude mice. MDSCs significantly increased number as a function xenograft growth were successfully...
The regulation of vascular permeability, leukocyte trafficking, and the integrity endothelial cell-cell contacts are closely linked by a complex mechanism interregulation. Here, we investigate role Krev interaction-trapped 1 (KRIT1), an adherens junction accessory protein required for stability, in regulating these functions.
Lymphangioleiomyomatosis (LAM) is a rare disease in women. Patients with LAM develop metastatic smooth-muscle cell adenomas within the lungs, resulting reduced pulmonary function. cells contain mutations tuberous sclerosis genes (TSC1 or TSC2), leading to up-regulation of mTORC1 activity and elevated proliferation. The origin remains unknown; however, inactivation Tsc2 gene mouse uterus resulted myometrial tumors exhibiting features, approximately 50% animals developed lung tumors. This...
Abstract Granulocytic myeloid infiltration and resultant enhanced neutrophil elastase (NE) activity is associated with poor outcomes in numerous malignancies. We recently showed that NE expression from infiltrating cells was high human prostate cancer xenografts mouse Pten-null tumors. further demonstrated directly stimulated to proliferate, migrate, invade, inhibition of vivo attenuated xenograft growth. Interestingly, reduced SERPINB1, an endogenous inhibitor, also correlates diminished...
Alopecia in varying patterns is a common feature of lupus erythematosus (LE).1 Several forms alopecia that are not specific to LE can occur the setting lupus, such as areata, telogen effluvium, and anagen effluvium. LE-specific alopecias those with histology consistent include acute, subacute, chronic cutaneous lupus. Common nonscarring diffuse hair thinning fragility acute scarring, erythematous scaly plaques follicular keratotic plugs, peripheral hyperpigmentation, central hypopigmentation...
Dermatomyositis (DM) classically presents as a dyad of typical cutaneous findings and varying degrees proximal muscle weakness. Interestingly, the development DM may signal underlying malignancy, numerous myositis-specific autoantibodies have been associated with this paraneoplastic phenomenon. Positivity for anti-TIF1gamma antibody, in particular, raises suspicion cancer-associated DM. Here, we present an unusual case antibody-positive that ultimately lead to diagnosis myelodysplastic...
Abstract Uterine leiomyomas, commonly referred to as fibroids, are benign, estrogen sensitive smooth muscle tumors that occur in the myometrium of uterine wall. Leiomyomas common, it is estimated 60% reproductive-aged women affected, and 80% develop leiomyomas during their lifetime. In fact, leading cause abnormal menstrual bleeding or pain, well number one reason for hysterectomy. Novel treatment options necessary current treatments limited anti-estrogen therapy Estrogen known have an...
Changes in the stability of endothelial cell‐cell contacts are commonly associated with chronic and acute vascular inflammation. However, it remains unclear how changes contact impact progress KRIT1‐deficient animals lack adherens junction accessory protein KRIT1, exhibit a loss stability. Krit1 +/‐ mice increased baseline microvessel permeability, but maintain normal leukocyte responses. Stimulation Krit1+/‐ various inflammatory mediators enhanced edema formation not activation. exhibited...
<div>Abstract<p>Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer other malignancies. Although have the ability to suppress T-cell function, little known about direct impact these innate on tumor growth. Here, it reported that suppressor (MDSC) are predominant tumor-infiltrating xenografts established athymic nude mice. MDSCs significantly increased number as a function xenograft...
<div>Abstract<p>Granulocytic myeloid infiltration and resultant enhanced neutrophil elastase (NE) activity is associated with poor outcomes in numerous malignancies. We recently showed that NE expression from infiltrating cells was high human prostate cancer xenografts mouse <i>Pten</i>-null tumors. further demonstrated directly stimulated to proliferate, migrate, invade, inhibition of <i>in vivo</i> attenuated xenograft growth. Interestingly, reduced...
<p>Supplementary Figure 3. Epigenetic repression of endogenous NE inhibitors in LNCaP cells.</p>
<p>Supplementary Figure 2. EGF does not induce SERPINB1 expression in prostate cancer cells.</p>
<p>Supplementary Figure 1. SERPINB1 expression is reduced in Pten-null compared to wild type mouse prostates.</p>
<p>High power image of neutrophil elastase localization in a xenograft.</p>
<p>Depletion of MDSCs suppresses prostate cancer xenograft proliferation.</p>
<p>High CD33 expression predicts poor outcomes in prostate cancer patients.</p>
<p>High power image of neutrophil elastase localization in a xenograft.</p>
<p>Depletion of MDSCs suppresses prostate cancer xenograft proliferation.</p>
<p>High CD33 expression predicts poor outcomes in prostate cancer patients.</p>
<p>Supplementary Figure 3. Epigenetic repression of endogenous NE inhibitors in LNCaP cells.</p>
<p>Supplementary Figure 2. EGF does not induce SERPINB1 expression in prostate cancer cells.</p>