A5072422168- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Osteoarthritis Treatment and Mechanisms
- Marine Biology and Environmental Chemistry
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Reconstructive Surgery and Microvascular Techniques
- Microwave Engineering and Waveguides
- Force Microscopy Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Antenna Design and Analysis
- Congenital limb and hand anomalies
- Lipid Membrane Structure and Behavior
- Dendrimers and Hyperbranched Polymers
- Bone fractures and treatments
- Energy Harvesting in Wireless Networks
- Lubricants and Their Additives
- Total Knee Arthroplasty Outcomes
- Photonic and Optical Devices
- Antimicrobial agents and applications
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Anatomy and Medical Technology
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
Wuxi No.2 People's Hospital
2019-2025
Soochow University
2018-2025
Weizmann Institute of Science
2016-2025
Hangzhou Normal University
2025
Beihang University
2022-2023
Jiangxi Science and Technology Normal University
2023
Zhejiang University
2011-2022
Guangdong University of Technology
2019-2022
Xiamen University
2010-2021
Northwestern Polytechnical University
2020-2021
The strong surface hydration layer of nonfouling materials plays a key role in their resistance to nonspecific protein adsorption. Poly(sulfobetaine methacrylate) (polySBMA) is an effective material that can resist adsorption and cell adhesion. About eight water molecules are tightly bound with one sulfobetaine (SB) unit, additional over 8:1 ratio mainly swell the polySBMA matrix, which obtained through measurement T(2) relaxation time by low-field nuclear magnetic resonance (LF-NMR). This...
Slippery surfaces using lipids In engineered systems, a reduction in friction can come from the use of lubricants or through surface coatings that are inherently slippery. For most hydrogels, which cross-linked polymers heavily swelled with water, lubrication typically comes trapped liquids help to form slippery surface. Drawing inspiration articular cartilage part uses lipid boundary layer, Lin et al. designed hydrogels small concentrations continuously exuded toward make layer (see...
Polymer-protein interactions are crucial for determining the activity of both polymer and protein many bio-related applications. Poly(ethylene glycol) (PEG) as a well-known antifouling material is often coated on surfaces to form highly solvated brushes, which exhibit excellent protein-repellent properties. However, unlike surface-induced effects, little known about intrinsic PEG-protein in aqueous solution, an important yet neglected problem. Here, we investigate between PEG proteins...
In the course of evolution, nature has achieved remarkably lubricated surfaces, with healthy articular cartilage in major (synovial) joints being prime example, that can last a lifetime as they slide past each other ultralow friction (friction coefficient μ = force to surfaces other/load compressing < 0.01) under physiological pressures (up 10 MPa or more)). Such properties are unmatched by any man-made materials. The precise mechanism low between such sliding tissues, which is closely...
Hydration lubrication has emerged as a new paradigm for in aqueous and biological media, accounting especially the extremely low friction (friction coefficients down to 0.001) of articular cartilage joints. Among ensemble molecules acting joint, phosphatidylcholine (PC) lipids have been proposed key forming, complex with other including hyaluronic acid (HA), robust layer on outer surface cartilage. HA, ubiquitous synovial joints, is not itself good boundary lubricant, but binds PC at...
Environmentally responsive hydrogels for drug delivery.
Blood stability, active targeting, and controlled drug release are the most important features to design desirable carriers. Here, we demonstrate a zwitterionic biodegradable cross-linked micelle based on penta-block copolymer, which utilizes poly(carboxybetaine methacrylate) as hydrophilic segment, poly(ε-caprolactone) hydrophobic poly(S-2-hydroxyethyl-O-ethyl dithiocarbonate (PSODMA) block thiol protecting segment for cross-linking, cyclic Arg-Gly-Asp-d-Tyr-Lys [c(RGDyK)] targeting ligand....
Much attention has been drawn to targeted nanodrug delivery systems due their high therapeutic efficacy in cancer treatment. In this work, doxorubicin (DOX) was incorporated into a zwitterionic arginyl–glycyl–aspartic acid (RGD)-conjugated polypeptide by an emulsion solvent evaporation technique with drug loading content (45%) and efficiency (95%). This nanoformulation showed excellent colloidal stability at dilution serum. The pH-induced disintegration enzyme-induced degradation of the were...
Abstract Background Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related bone homeostasis, has been proven affected by melatonin. However, whether could play its anti-osteolysis effects through reprogramming gut remains elusive. Results Here,...
PMPCylated liposomes injected into mice joints show a massive increase in retention half-life compared with PEGylated (or hyaluronan, HA), making them promising candidates as boundary lubricants at articular cartilage, or drug carriers.
Polymer-drug conjugates are commonly used as nano drug vehicles (NDVs) to delivery anticancer drugs. Zwitterionic polymers ideal candidates conjugate drugs because they show higher resistance nonspecific protein adsorption in complex media than that of nonionic water-soluble polymers, such poly(ethylene glycol). However, the charge balance characteristics zwitterionic NDVs will be broken from inclusion additional charged groups brought by conjugated or functional groups, leading loss...
The surface primary amines of generation five poly(amido amine) (G5 PAMAM) dendrimer were modified by different amounts carboxybetaine acrylamide (CBAA). As a result, the fully molecules (CBAA-PAMAM-20, obtained from 20:1 molar ratio CBAA to amino groups in modification solution) show excellent compatibility with protein and cells. CBAA-PAMAM-20 fibrinogen (Fg) could coexist solution without forming aggregation, indicating very weak interaction force between fibrinogen. exhibits almost...
We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined coefficient of friction μ < 10–2) via hydration lubrication at physiological salt concentrations pressures. In contrast, sterically protected by...
Polyethylene glycol (PEG) is considered to be the most effective material prolong circulation time of nanoparticles by reducing non-specific protein adsorption in blood. However, it recognized that PEG decomposes physiological solutions, and an anti-PEG antibody has been detected some normal blood donors as a response injection with PEGylated polymer particles. Zwitterionic polymers are potential alternatives for biomedical applications because their super resistance adsorption. Thus,...