A5017434251- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Electrochemical Analysis and Applications
- Neurological disorders and treatments
- 3D Printing in Biomedical Research
- Sleep and Wakefulness Research
- Industrial Vision Systems and Defect Detection
- Transcranial Magnetic Stimulation Studies
- ECG Monitoring and Analysis
- stochastic dynamics and bifurcation
- Cardiac electrophysiology and arrhythmias
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Neural Networks and Applications
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Prosthetics and Rehabilitation Robotics
- Image Processing and 3D Reconstruction
Italian Institute of Technology
2016-2025
University of Genoa
2007-2025
Ospedale Policlinico San Martino
2023-2024
Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro
2019-2023
Songdo Hospital
2023
Global Engineering and Materials (United States)
2022-2023
Bioengineering Technology and Systems (Italy)
2021
University of Kansas Medical Center
2020
Robert Bosch (Germany)
2011
BioElectronics (United States)
2002
Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. We used RNAi knockdown expression neuronal cultures showed that this treatment specifically reduced the synaptic of metabotropic glutamate receptor 5 (mGluR5), but did affect other major proteins. The...
Neurons extracted from specific areas of the Central Nervous System (CNS), such as hippocampus, cortex and spinal cord, can be cultured in vitro coupled with a micro-electrode array (MEA) for months. After few days, neurons connect each other functionally active synapses, forming random network displaying spontaneous electrophysiological activity. In spite their simplified level organization, they represent an useful framework to study general information processing properties basic learning...
Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions are known to involve both excitatory inhibitory cells. However, if how inhibition regulates these activity is unclear. Using fluorescence-targeted electrophysiological recording cell-specific optogenetic manipulation in anesthetized non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin somatostatin positive...
Neuronal assemblies within the nervous system produce electrical activity that can be recorded in terms of action potential patterns. Such patterns provide a sensitive endpoint to detect effects variety chemical and physical perturbations. They are function synaptic changes do not necessarily involve structural alterations. In vitro neuronal networks (NNs) grown on micro-electrode arrays (MEAs) respond neuroactive substances as well vivo brain. As such, they constitute valuable tool for...
The development of robotic devices for rehabilitation is a fast-growing field. Nowadays, thanks to novel technologies that have improved robots’ capabilities and offered more cost-effective solutions, are increasingly being employed during clinical practice, with the goal boosting patients’ recovery. Robotic also widely used in context neurological disorders, where it often provided variety different fashions, depending on specific function be restored. Indeed, effect robot-aided...
Abstract Characterization and modeling of biological neural networks has emerged as a field driving significant advancements in our understanding brain function related pathologies. As today, pharmacological treatments for neurological disorders remain limited, pushing the exploration promising alternative approaches such electroceutics. Recent research bioelectronics neuromorphic engineering have fostered development new generation neuroprostheses repair. However, achieving their full...
Despite considerable advancement of first choice treatment (pharmacological, physical therapy, etc.) over many decades, neurological disorders still represent a major portion the worldwide disease burden. Particularly concerning, trend is that this scenario will worsen given an ever expanding and aging population. The different methods brain stimulation (electrical, magnetic, are, on other hand, one most promising alternatives to mitigate suffering patients families when conventional fall...
Abstract Upper-limb movement characterization is crucial for many applications, from research on motor control, to the extraction of relevant features driving active prostheses. While this usually performed using electrophysiological and/or kinematic measurements only, collection tactile data during grasping movements could enrich overall information about interaction with external environment. We provide a dataset collected 10 healthy volunteers performing 16 tasks, including simple (i.e.,...
Abstract To investigate distributed synaptic plasticity at the cell assembly level, we used dissociated cortical networks from embryonic rats grown on grids of 60 extracellular substrate‐embedded electrodes (micro‐electrode arrays). We developed a set experimental protocols based pairing tetanic bursts (20 Hz) with low‐frequency stimuli (≤ 1 Hz), delivered through two separate channels array (i.e. associative stimulation). tested our large data 26 stable cultures, selected basis both their...
Synapsins (Syns) are synaptic vesicle (SV) phosphoproteins that play a role in transmission and plasticity. Mutation of the SYN1 gene results an epileptic phenotype mouse man, implicating SynI control network excitability. We used microelectrode array patch-clamp recordings to study activity primary cortical neurons from wild-type (WT) or knockout (KO) mice. deletion was associated with increased spontaneous evoked activities, more frequent sustained bursts action potentials high degree...
One of the key properties intelligent behaviors is capability to learn and adapt changing environmental conditions. These features are result continuous intense interaction brain with external world, mediated by body. For this reason "embodiment" represents an innovative very suitable experimental paradigm when studying neural processes underlying learning new adapting unpredicted situations. To purpose, we developed a novel bidirectional interface. We interconnected in vitro neurons,...
ORIGINAL RESEARCH article Front. Neural Circuits, 14 March 2013 Volume 7 - | https://doi.org/10.3389/fncir.2013.00040