A5089167799- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Prenatal Substance Exposure Effects
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Opioid Use Disorder Treatment
- Neonatal and fetal brain pathology
- Vagus Nerve Stimulation Research
- Intensive Care Unit Cognitive Disorders
- Stress Responses and Cortisol
McLean Hospital
2021-2025
Harvard University
2021-2025
University of Kentucky
2024-2025
Wake Forest University
2023
Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes Alzheimer's disease (AD). Since the cellular mechanisms governing this relationship are poorly understood, we explored whether ATP-sensitive potassium (KATP) channels, which couple changes in energy availability with excitability, play role AD pathogenesis. First, demonstrate that KATP channel subunits Kir6.2/KCNJ11 SUR1/ABCC8 were...
Opioid use disorder is marked by a progressive change in the motivation to administer drug even presence of negative consequences. After long periods abstinence, urge return taking intensifies over time, known as incubation craving. Conditioned responses drug-related stimuli, can acquire motivational properties and exert control motivated behaviors leading relapse. Although, preclinical data suggest that behavioral expression opioid similar between male female rodents, we do not have...
Opioid use disorder is marked by a progressive change in the motivation to administer drug even presence of negative consequences. After long periods abstinence, urge return taking intensifies over time, known as incubation craving. Conditioned responses drug-related stimuli, can acquire motivational properties and exert control motivated behaviors leading relapse. Although, preclinical data suggest that behavioral expression opioid similar between male female rodents, we do not have...
Introduction Rates of relapse to drug use during abstinence are among the highest for opioid disorder (OUD). In preclinical studies, reinstatement drug-seeking has been extensively studied as a model relapse–but work primarily in males. We asked whether biological sex contributes behaviors comprising self-administration prescription oxycodone rats, and we calculated relative contribution these behavioral measures male female rats. Materials methods Rats were trained self-administer (8 days,...
Oxycodone is one of the most widely prescribed and misused opioid painkillers in United States. Evidence suggests that biological sex hormonal status can impact drug reward humans rodents, but extent to which these factors influence rewarding effects oxycodone unclear. The purpose this study was utilize place conditioning determine female on expression conditioned rats. Gonadally intact adult Sprague-Dawley male rats were used test: (1) whether both sexes express at similar doses, (2)...
Abstract Opioid use disorder is marked by a progressive change in the motivation to administer drug even presence of negative consequences. After long periods abstinence, urge return taking intensifies over time, known as incubation craving. Conditioned responses drug-related stimuli, can acquire motivational properties and exert control motivated behaviors leading relapse. Although, preclinical data suggest that behavioral expression opioid similar between male female rodents, we do not...
Abstract The current opioid epidemic has dramatically increased the number of children who are prenatally exposed to opioids, including oxycodone. A social and cognitive abnormalities have been documented in these as they reach young adulthood. However, little is known about mechanisms underlying developmental effects prenatal exposure. Microglia, resident immune cells brain, respond acute exposure Moreover, microglia sculpt neural circuits during healthy development. Indeed, we recently...