A5020232649- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Telomeres, Telomerase, and Senescence
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Science, Research, and Medicine
- Mass Spectrometry Techniques and Applications
- Radiation Therapy and Dosimetry
- Electric Vehicles and Infrastructure
- Click Chemistry and Applications
- Advanced Battery Technologies Research
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Hydrogels: synthesis, properties, applications
- Renal Diseases and Glomerulopathies
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA and protein synthesis mechanisms
- Dialysis and Renal Disease Management
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
Texas Tech University
2022-2023
Texas Tech University Health Sciences Center
2022-2023
Delta Air Lines (United States)
2015-2020
Rutgers, The State University of New Jersey
2012-2017
Research Triangle Park Foundation
2015
Cornell University
2011
St George Hospital
2008
UNSW Sydney
2008
National Cancer Institute
2006
Center for Cancer Research
2006
This study evaluates targeted liposomes loaded with the α-particle generator <sup>225</sup>Ac to selectively kill prostate-specific membrane antigen (PSMA)–expressing cells aim assess their potential for antivascular radiotherapy. <b>Methods:</b> In this study, PEGylated were and labeled mouse antihuman PSMA J591 antibody or A10 aptamer. The targeting selectivity, extent of internalization, killing efficacy evaluated on monolayers prostate cancer intrinsically expressing (human LNCaP rat...
ABSTRACT The regulation by two transcriptional activators of flagellar expression (FlhD and FlhC) the chemotaxis methyl-accepting protein Aer was studied with glass slide DNA microarrays. An flhD ::Kan insertion an aer deletion were independently introduced into Escherichia coli K-12 strains, effects upon gene investigated. Altogether, altered 29 operons known function. Among them Aer, which in turn regulated a subset these operons, namely, ones involved anaerobic respiration...
A subset of cancers across multiple histologies with predominantly poor outcomes use the alternative lengthening telomeres (ALT) mechanism to maintain telomere length, which can be identified robust biomarkers. ALT has been reported prevalent in high-risk neuroblastoma and certain sarcomas, are a major clinical challenge that lack targeted therapeutic approaches. Here, we found variety pediatric adult cancer histologies, including carcinomas. Patient-derived cell lines from neuroblastomas,...
We investigated the feasibility and efficacy of a drug delivery strategy to vascularized cancer that combines targeting selectivity with high uptake by targeted cells bioexposure delivered chemotherapeutics. Targeted lipid vesicles composed pH responsive membranes were designed reversibly form phase-separated domains, which are utilized tune vesicle's apparent functionality permeability. During circulation, mask functional ligands stably retain their contents. Upon extravasation in tumor...
// Takahiro Yoshida 1, *, $ , Kideok Jin * Hong Song 2 Sunju Park 1 David L. Huso 3, @ Zhe Zhang Han Liangfeng Charles Zhu 4 Frank Bruchertseifer 5 Alfred Morgenstern George Sgouros Saraswati Sukumar Department of Oncology, Johns Hopkins University School Medicine, Maryland, USA Radiology and Radiological Science, 3 Molecular Comparative Pathobiology, Biomedical Engineering, Rutgers University, Piscataway, NJ, European Commission, Joint Research Centre, Institute for Transuranium Elements,...
Abstract This study aims to evaluate the effect on killing efficacy of intracellular trafficking patterns α-particle emitters by using different radionuclide carriers in setting targeted antivascular α-radiotherapy. Nanocarriers (lipid vesicles) prostate-specific membrane antigen (PSMA), which is unique human neovasculature for a variety solid tumors, were loaded with generator actinium-225 and compared PSMA-targeted radiolabeled antibody. Actinium-225 emits total four α-particles per decay,...
Abstract Malignant gliomas are aggressive forms of primary brain tumors characterized by a poor prognosis. The most successful treatment so far is the local implantation polymer carriers (Gliadel® wafers) for sustained release carmustine. To improve effectiveness drug treatment, new and pharmacological agents currently being investigated. Of particular interest set novel thermo‐gelling polymers controlled hydrophobic drugs such as paclitaxel (e.g., OncoGel™). Herein, we use computational...
Effective targeting by uniformly functionalized nanoparticles is limited to cancer cells expressing at least two copies of targeted receptors per nanoparticle footprint (approximately ≥2 × 10(5) receptor cell); such a density supports the required multivalent interaction between neighboring and ligands from single nanoparticle. To enable selective below this density, on surface lipid vesicles were displayed in clusters that designed form acidic pH tumor interstitium. Vesicles with clustered...
<div>Abstract<p>A subset of cancers across multiple histologies with predominantly poor outcomes use the alternative lengthening telomeres (ALT) mechanism to maintain telomere length, which can be identified robust biomarkers. ALT has been reported prevalent in high-risk neuroblastoma and certain sarcomas, are a major clinical challenge that lack targeted therapeutic approaches. Here, we found variety pediatric adult cancer histologies, including carcinomas. Patient-derived cell...
Supplementary Data from Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation p53 Function
Supplementary Data from Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation p53 Function
Supplementary Data from Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation p53 Function
Supplementary Data from Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation p53 Function
<p>Demonstration of enhanced expression PSMA by HUVEC exposed to cell cultured media.</p>
<p>Dissociation constants for targeted vesicle constructs.</p>
<p>Viability (evaluated after one doubling time) of PSMA-positive HUVEC as a function delivered radioactivity per cell.</p>
<p>Viability (evaluated after one doubling time) of PSMA-positive HUVEC as a function delivered radioactivity per cell.</p>
<p>Demonstration of enhanced expression PSMA by HUVEC exposed to cell cultured media.</p>