Chronic infection with Pseudomonas aeruginosa is associated progressive deterioration in lung function cystic fibrosis (CF) patients. The purpose of this trial was to assess the efficacy and safety tobramycin nebuliser solution (TNS) nebulised colistin CF patients chronically infected P. . One-hundred fifteen patients, aged ≥6 yrs, were randomised receive either TNS or colistin, twice daily for 4 weeks. primary end point an evaluation relative change from baseline, as measured by forced...

This international phase III study of inhaled dry powder mannitol was a randomised, double-blind, 26-week study, followed by further 26-week, open-label (OL) extension. 324 cystic fibrosis (CF) patients were in 3:2 ratio, to (400 mg b.i.d. ) and control groups. The primary efficacy end-point determine the change forced expiratory volume 1 s (FEV over double-blind phase. Secondary end-points included changes vital capacity pulmonary exacerbations. A significant improvement FEV seen 26 weeks...

We examined whether arterial hypoxemia impairs incremental exercise performance in subjects with interstitial lung disease (ILD). Seven underwent two tests on a bicycle ergometer random order; one while breathing room air (RA), and the other 60% O2. Maximal was impaired all subjects: maximal oxygen uptake (peak VO2) 56 +/- 4% predicted (+/- SEM); demonstrated significant desaturation during RA (mean 11 1%). Breathing O2 resulted increase peak VO2 (RA: 1.32 0.05 L/min; O2: 1.58 0.08 p <...

Our aim was to determine whether inspiratory muscle fatigue changes breathing pattern and any seen occur before mechanical develops. Nine normal subjects breathed through a variable resistance with predetermined mouth pressure (Pm) during inspiration fixed ratio of time total breath duration. Breathing after resistive (recovery pattern) compared at rest CO2 rebreathing (control for each subject. Relative rapid shallow also in experiments electromyogram evidence diaphragmatic where Pm...

To assess the effect of normal respiratory resistive load on ventilation (VE) and motor output during exercise, we studied flow-proportional pressure assist (PA) (2.2 cmH2O.l-1.s) various ventilatory parameters progressive exercise to maximum in six healthy young men. We also measured dynamic lung compliance (Cdyn) resistance (RL) calculated time course muscle (Pmus) breath assisted unassisted states at a sustained level corresponding 70–80% subject's O2 consumption. Unlike helium breathing,...

During progressive exercise ventilation (VI) initially increases through in both tidal volume (VT) and respiratory frequency (f) but at high levels of further VI are almost completely due to f a VT plateau is seen. We wished determine whether the presence tachypneic influence related very or it represents stereotypic response system VI. therefore compared breathing pattern six subjects during maximal incremental (ME) with that same when similar were obtained by combination submaximal...

Lung volumes were measured at rest and during exercise by an open-circuit N2-washout technique in patients with interstitial lung disease (ILD). Exercise tidal flow-volume (F-V) curves also compared maximal F-V to investigate whether these demonstrated flow limitation. Seven underwent 4 min of constant work rate bicycle ergometer 40, 70, 90% their previously determined rates. End-expiratory volume total capacity near the end each period exercise. There was no significant change...

We have previously shown that respiratory factors (arterial hypoxemia and/or pulmonary mechanics) contribute to limit maximal incremental exercise in interstitial lung disease (ILD). In this study, we tested the hypothesis arterial hypoxemia, not mechanics, primarily limits subjects with ILD. Seven ILD underwent two tests random order. Test 1: breathing room air (RA); 2: 60% O2 added external dead space (O2VD). Added VD was used prevent fall minute ventilation (VI) while O2. All demonstrated...

We report eight cases of patients with severe acne who were treated isotretinoin and developed painful nodules in the axillae groin, consistent hidradenitis suppurativa (HS). The pathogenesis HS is still not completely understood; recent research from a study 2011 biopsies lesions showed reduction or absence sebaceous glands compared normal skin HS, suggesting that this contributes to disease. Interestingly, main effect decrease size action glands, so hypothetically, as acts by reducing...

BACKGROUND--Exercise testing has become an important tool in the diagnosis and treatment of restrictive lung disease. The reproducibility variables measured during exercise was examined subjects with stable METHODS--Six subjects, who had never previously undergone testing, each underwent three maximal incremental studies on a bicycle ergometer conducted 28 day period. RESULTS--Data collected at rest, before exercise, were not significantly different study days. Comparison results end tests...

Inspiratory muscle fatigue and pulmonary edema are both known to cause rapid shallow breathing. It has been suggested that exercise tolerance in patients with disease cardiac may be limited by the development of inspiratory edema, respectively, at maximal exercise. If these hypotheses correct, breathing pattern during recovery from should compared This study was performed test hypotheses. Seven chronic obstructive (COPD), 8 interstitial lung (ILD), 7 (CD) (mitral valve or left ventricular...

<h3>Background</h3> The current lifetable approach to survival estimation is favoured by CF registries. Recognising the limitation of this approach, we examined utility a parametric model project birth cohort estimates beyond follow-up period, where short duration meant median were indeterminable. <h3>Methods</h3> Parametric models fitted observed survivorship data from US Foundation (CFF) Patient Registry 1980–1994 cohort. Model-predicted was estimated. best fitting applied Cystic Fibrosis...

Recent reports have suggested that low-dose nebulized morphine may improve exercise tolerance in patients with interstitial lung disease (ILD) by acting on peripheral opioid-sensitive pulmonary receptors. We therefore examined whether the administration of would influence dyspnea or breathing pattern during subjects ILD and their performance. Each six underwent three maximal incremental cycle ergometer tests, each test separated from last at least 3 d. was similar except 30 min before...

We examined the effects of dead space (VD) loading on breathing pattern during maximal incremental exercise in eight normal subjects. Addition external VD was associated with a significant increase tidal volume (VT) and decrease respiratory frequency (f) at moderate high levels ventilation (VI); VI 120 l/min, VT f added were 3.31 +/- 0.33 liters 36.7 6.7 breaths/min, respectively, compared 2.90 0.29 41.8 7.3 breaths/min without VD. Because does not change CO2 inhalation heavy (Gallagher et...

1. Seven active subjects (24 +/‐ 1 years; maximal oxygen uptake (VO2,max), 3.77 0.2 l min‐1; mean S.E.M.) performed constant work rate heavy exercise (CWHE, approximately 80% of incremental rate) to exhaustion on 2 days, one with (unload) and without (control) respiratory muscle unloading. 2. With unloading, a special device applied flow‐proportional mouth pressure assist (positive inspiratory (I), negative expiratory (E) flows) throughout each breath. No occurred during control CWHE. To...

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition characterized by recurrent, painful abscesses, nodules, and draining sinus tracts. The primary sites of involvement are the intertriginous areas axilla, groin, perianal, perineal, inframammary regions. prevalence HS estimated to be 1% 4%,1Dessinioti C. Katsambas A. Antoniou suppurrativa (acne inversa) as systemic disease.Clin Dermatol. 2014; 32: 397-408Abstract Full Text PDF PubMed Scopus (60) Google Scholar...

Repeated bouts of submaximal exercise are an important part most pulmonary rehabilitation programmes. Patients with moderate-to-severe cystic fibrosis (CF) often demonstrate oxygen desaturation during exercise, which may limit their ability to participate in these This study examines whether arterial contributes limitation by testing supplemental O 2 improves capacity. Eight patients CF (mean forced expiratory volume one second 41% predicted) each underwent two tests on a bicycle ergometer...

The relative importance of laryngeal afferents in the cough reflex humans is unknown. This study was designed to investigate superior nerve induced by inhaled nebulized citric acid awake humans. Nine healthy volunteers had their thresholds measured after conduction blockade and a sham block. Of nine subjects, four showed no change threshold anesthesia, three increased block compared with block, two decreased geometric means for vs. tests were 16 +/- 13 (SD) 15 8% acid, respectively. There...