A5075963904- Melanoma and MAPK Pathways
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Retinal Development and Disorders
- Protein Tyrosine Phosphatases
- Estrogen and related hormone effects
Universitat Autònoma de Barcelona
2022-2023
Vall d'Hebron Institut de Recerca
2022-2023
Endometrial cancer (EC) is the most common type of gynecologic in women developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival patients high-risk EC tumors poor, indicating a need for novel therapies. The MEK5-ERK5 pathway activated response to growth factors and different stressors, including oxidative stress cytokines. Previous evidence supports role pathology several cancers. We investigated ERK5 EC. In silico analysis PanCancer Atlas dataset...
Death receptor ligand TRAIL is a promising cancer therapy due to its ability selectively trigger extrinsic apoptosis in cells. However, TRAIL-based therapies humans have shown limitations, mainly inherent or acquired resistance of tumor To address this issue, current efforts are focussed on dissecting the intracellular signaling pathways involved TRAIL, identify strategies that sensitize cells TRAIL-induced cytotoxicity. In work, we describe oncogenic MEK5-ERK5 pathway as critical regulator...
Abstract Death receptor ligand TRAIL is a promising cancer therapy due to its ability selectively trigger extrinsic apoptosis in cells. However, TRAIL–based therapies humans have shown limitations, mainly inherent or acquired resistance of tumor To address this issue, current efforts are focussed on dissecting the intracellular signaling pathways involved TRAIL, identify strategies that sensitize cells TRAIL-induced cytotoxicity. In work, we describe oncogenic MEK5-ERK5 pathway as critical...
Abstract Endometrial cancer (EC) is the most common type of gynaecologic in women developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival patients high-risk EC tumors poor, indicating a need for novel molecular therapies. The MEK5-ERK5 pathway activated response to growth factors and different forms stress, including oxidative stress cytokines. Previous evidence support role pathology several cancers. We have investigated ERK5 EC. In silico analysis...