A5037437881- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Reproductive System and Pregnancy
- Connective tissue disorders research
- Blood disorders and treatments
- Wnt/β-catenin signaling in development and cancer
- Histiocytic Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Glycosylation and Glycoproteins Research
- Tuberous Sclerosis Complex Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Bone and Dental Protein Studies
- Neutropenia and Cancer Infections
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Ovarian cancer diagnosis and treatment
Medical University of Lodz
2014-2023
Bial (Portugal)
2015
The inactivation of tumor suppressor genes located within 9p21 locus (CDKN2A, CDKN2B) occurs in up to 30% children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), but its independent prognostic significance remains controversial. In order investigate the impact deletions and promoter methylation 9p21, 641 newly diagnosed BCP-ALL using specific multiplex ligation-dependent probe amplification (MS-MLPA) were investigated. A total 169 (26.4%) microdeletions detected, which 71...
The role of HLA‐G is extensively studied in cancer due to its inhibition the immune response. Several polymorphisms gene have been reported significantly affect expression. We, therefore, investigated whether functionally relevant polymorphisms, ‐725C/G/T, and 14‐base pair, any influence on susceptibility diffuse large B‐cell lymphoma (DLBCL) clinical course. were genotyped 207 previously untreated patients with DLBCL 150 unrelated controls. A significant difference genotype distribution...
We prospectively examined whether surface expression of Cytokine Receptor-Like Factor 2 (CRLF2) on leukemic blasts is associated with survival and induction treatment response in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Flow cytometric analysis bone marrow-derived cells revealed that 7.51% (29/286) 386 BCP-ALL patients were CRLF2-positive (CRLF2pos) at diagnosis. The median minimal residual disease (MRD) was lower CRLF2pos than CRLF2-negative (CRLF2neg) day...
Neutropenia is a hematological condition characterized by decrease in absolute neutrophil count (ANC) peripheral blood, typically classified adults as mild (1-1.5 × 109/L), moderate (0.5-1 or severe (< 0.5 109/L). It can be categorized into two types: congenital and acquired. Congenital chronic neutropenia (SCN) arises from mutations various genes, with different inheritance patterns, including autosomal recessive, dominant, X-linked forms, often linked to mitochondrial diseases. The most...
Abstract Background Craniofrontonasal syndrome (CFNS) is a rare X-linked disorder that results from pathogenic variants in the EFNB1 gene. The paradoxically presents with greater severity of symptoms heterozygous females than hemizygous males. Results We have recruited and screened female cohort affected CFNS. Our primary finding was description monozygotic twins, i.e., patients 5 6, discordant for CFNS phenotype. Intriguingly, patient presented classical gestalt, whereas 6 manifested only...
Abstract Background: Craniofrontonasal syndrome (CFNS) is a rare X-linked disorder that results from pathogenic variants in the EFNB1 gene. The paradoxically presents with greater severity of symptoms heterozygous females than hemizygous males. Results: Our primary finding was description monozygotic twins, i.e., patients 5 & 6, discordant for CFNS phenotype. Intriguingly, patient presented classical gestalt, whereas 6 manifested only very subtle craniofacial features, not resembling...