A5008103439- Medicinal Plant Research
- Agricultural and Biological Research
- Essential Oils and Antimicrobial Activity
- 14-3-3 protein interactions
- Ion Transport and Channel Regulation
- Protein Kinase Regulation and GTPase Signaling
- Public Health and Nutrition
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Phytoestrogen effects and research
- Computational Drug Discovery Methods
- Ginger and Zingiberaceae research
- Natural Products and Applications
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Biological Activities
- Advanced Breast Cancer Therapies
- Chemical Synthesis and Analysis
- Herbal Medicine and Trade Cooperation
- Cytokine Signaling Pathways and Interactions
- Hibiscus Plant Research Studies
- Photodynamic Therapy Research Studies
- Endoplasmic Reticulum Stress and Disease
- Phytochemistry and Bioactive Compounds
Muhammadiyah University Purwokerto
2011-2023
Cardiff University
2017-2020
Mahidol University
2014
As the pandemic of coronavirus disease 2019 (COVID-19) continues while there is no drug and vaccine available, every effort to discover one should be considered. This review aimed discuss potential use jamu, Indonesian traditional herbal medicine, deal with COVID-19 by following those more-established Chinese medicine (TCM). The online literature search using PubMed database, as well circulars from Ministry Health, were carried out collect data up June 07, 2020. TCM for treatment prevention...
Malaysia merupakan negara tujuan terdekat dari tenaga kerja migran Indonesia untuk bekerja di luar negeri. Tahun 2026 diproyeksikan mencapai 2,7 juta dan 50% pekerja ilegal yang tidak memiliki akses terhadap fasilitas pendidikan kesehatan. Keterbatasan tersebut menjadikan kelompok illegal anak-anaknya menjadi rentan menghadapi permasalahan Kegiatan ini dilaksanakan dengan menggandeng mitra Sanggar Bimbingan (SB) Kampong Bharu Kuala Lumpur melakukan edukasi Perilaku Hidup Bersih Sehat (PHBS)...
COVID-19 global pandemic increases the usage of vitamin supplement products. However, easy access to purchase and consume product risk for its misuse. Lack information or misinformation available leads abuse. Teachers' parents' role in deciding choice use products pupil children is crucial. Thus, a program was held provide about correct teachers parents. The performed parents TK Aisyiyah Ledug via online. attractive audio-visual materials were delivered animation video, artistic leaflet,...
The application of the aryloxy triester phosphoramidate prodrug technology to ISS-610-Met improves its ability inhibit STAT3 in cells.
Abstract SPAK and OSR1 are two protein kinases that play critical roles in regulating ion homeostasis. They activated under osmotic stress through phosphorylation by their upstream WNK at a conserved threonine site on T‐loops. Additionally, phosphorylate highly serine residue S‐motif, the function of which remains elusive. Using affinity pull down mass spectrometry, we identified E3 ubiquitin ligase complex Cullin 4‐DDB1‐WDR3/WDR6 as binder to kinase SPAK/OSR1 S‐motif...
ABSTRAK Sambiloto merupakan tanaman yang sejak dahulu digunakan sebagai obat tradisional karena khasiatnya sangat banyak diantaranya adalah perangsang daya kekebalan tubuh. Telah dilakukan pengeringan terhadap sambiloto dengan beberapa metode. Penelitian bertujuan untuk mengetahui apakah metode atau cara dapat mempengaruhi kadar flavonoid total pada ekstrak herba ( Andrographis paniculata ). Ekstraksi menggunakan sokletasi dan uji KLT Densitometri. Hasil data Densitometri menunjukkan bahwa...
Based on the various benefit of bangle , anti-bacterial and anti -inflammatory effects its astringent effect rhizome potential to be developed as a lotion .T his research were aimed formulate ethanolic extract examine physical characteristic also irritation test against skin. Extraction was carried out by maceration method. Research used 3 formulas contain 6.75 % with variation triethanolamine concentration they 0.4% 0.45% 0.5% for formula I, II III. Negative control 0.5% without . Lotion...
Rosella is a very useful plant. Widely used as traditional medicine, its calyx functions antioxidant, antiseptic, diuretic, and anticholesterol. This research aimed at knowing the concentrate of providone toward condition good quality granule, taste reaction, detection content flanoid in instant garnule roselle extract. The fresh was pounded with mixer then abtained essence stearmed to lose water content, antil thick extract derived. granule rosella juice formulated wet granulation method 3...
Purwoceng (Pimpinella alpina Molk) is a traditional medicinal plant used for its aphrodisiac values. This was originated Dieng Plateu, Central Java, Indonesia. has been reported to contain steroid, flavonoids, glycoside, saponins, tannins, and phenolic. Based on secondary metabolite compounds of herbs, research need be done determine the other potential free radicals scavenger antibacterial activities Purwoceng. The objectives this are screen activity in vitro using DPPH (1,1...
ABSTRAK Telah dilakukan penelitian penetapan kadar tanin pada daun rambutan ( Nephelium lappaceum ) dengan metode spektrofotometri ultraviolet visibel. Penetapan untuk mengetahui jumlah yang terkandung dalam rambutan. Metode digunakan penyarian simplisia adalah maserasi. Ekstrak sudah didapat kemudian diencerkan, ditambahkan reagen Folin Denis dan Natrium Karbonat anhidrat, setelah itu dibaca panjang gelombang maksimum saat operating time tercapai. Reaksi pembentukan terjadi reduksi...
Abstract We investigated the major leaf isoflavonoid contents of Pueraria mirifica from three different cultivars (PM-III, PM-IV, and PM-V) using reverse RP-HPLC analysis. The proportions net levels puerarin, daidzin, genistin, daidzein in P. leaves were found to depend on plant cultivar correlate with cultivation temperature rainfall amount. crude leaf-extracts tested Yeast Estrogen Screen (YES) assay both human estrogen receptors (hERα hERβ). Their estrogenic activity was higher when...
Buah adas mengandung minyak atsiri antara lain anethole, fenchone dan metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteri pada bakteri Gram Positif Negatif. Penelitian ini bertujuan untuk membuat lotion dari buah menentukan antibakterinya terhadap Staphylococcus aureus Pseudomonas aeruginosa. dilakukan menggunakan yang diperoleh destilasi uap air dengan konsentrasi 1, 5, 10% (Formula I, II III). Kemudian tersebut diuji parameter fisik ditentukan antibakterinya. Hasil...
Abstract The specific targeting of protein‐protein interactions by phosphoserine‐containing small molecules has been scarce due to the dephosphorylation phosphoserine and its charged nature at physiological pH, which hinder uptake into cells. To address these issues, we herein report synthesis aryloxy triester phosphoramidates as prodrugs that are enzymatically metabolized release phosphoserine. This phosphoserine‐masking approach was applied a inhibitor 14‐3‐3 dimerization, generated...
ABSTRACT One of traditional medicine which can be used to treat ringworm and skin disorder caused by parasites is Senna alata. In vitro research showed that ethanolic extract ketepeng cina’s leaves has antifungal activity against Trichophyton mentagrophytes. This was aimed determine the effect varied concentration cina on physical properties cream dosage form. Creams were formulated with 3 variation alata extract, then determined characteristic its The results adhesion spreading creams...
ABSTRAK Telah dilakukan penelitian tentang aktivitas antijamur ekstrak etanol daun mimba ( Azadirachta indica ) terhadap Candida albicans dengan metode dilusi. Ekstrak tersebut dihasilkan cara soxhletasi dan maserasi menggunakan pelarut 70%. Penentuan kandungan senyawa dalam Kromatografi Lapis Tipis. Hasil yang diperoleh bahwa mempunyai . lebih efektifdalam menghambat membunuh jamur dibandingkan maserasi. Hal ini dapat dilihat dari perolehan Kosentrasi Hambat Minimum (KHM) Konsentrasi Bunuh...
Estrogen receptor beta (ERβ) is an isoform of estrogen that plays a role in breast cancer. An E3 ubiquitin ligase, murine double minute 2 (MDM2), can bind to ERβ and degrade it. Virtual screening protein-protein docking studies are one the approaches be performed discover FDA-approved drugs targeting interaction ERβ-MDM2 complex. This study aimed conduct virtual 1615 compounds between as initial potential cancer drugs. Biovia Discovery Studio 2021, ClusPro 2.0, PyRx 8.0, PyMOL software were...
Estrogen receptors alpha (ERα) and beta (ERβ) is highly expressed in different cancer cells. Inhibition of ERs by small molecules a promising approach to developing novel anticancer agents amidst increased endocrine therapy resistance. A heterocyclic molecule, 2-benzoxazolinone (2- BOA) its derivatives, found Acanthus ilicifolius leaves, possesses on varied cell types such as HeLa, MCF7, A-549, SW-480. However, the mechanism growth inhibition an enigma. This study aimed unmask activity 2-BOA...
Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening an effective approach breast drug discovery via estrogen receptor (ER) signaling. TRIM56, E3 ubiquitin protein ligase, can bind to and stabilize ER alpha. Thus, that inhibit or weaken interaction between alpha TRIM56 promising obtain novel yet specific drugs. In this study, we performed protein-protein studies virtual FDA-approved drugs from ZINC database against complex...
Graptophyllum pictum is a well-known folk medicine in Indonesia. The red leaves are widely used for their anti-inflammatory properties to relieve hemorrhoids. However, little known about what extent these can affect platelet aggregation. This study was aimed determine the anti-inflammation and anti-platelet aggregation activities of ethanolic extract (EEGP). Apart from ear hind-paw edema assay, bleeding time assay were also performed on male Wistar rats. test animals grouped into six groups:...
ABSTRAK Penggunaan antimikroba sintetik atau pengawet secara terus menerus pada makanan, seperti formalin jika dikonsumsi dapat menyebabkan timbulnya berbagai penyakit. Berdasarkan kejadian tersebut masyarakat mulai mencari alternatif lain dalam penggunaan dan yang lebih sedikit memberikan dampak negatif bagi kesehatan. Salah satunya diperoleh dari daun cocor bebek diketahui memiliki aktifitas bisa digunakan sebagai alami. Penelitian ini dilakukan untuk menentukan efektifitas ekstrak etanol...
Cervical cancer is a type of possessing the 3rd highest incidence among women worldwide. Today’s therapies against are still ineffective, thus people seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment conducted to study ability chloroform extract E. leaves and its isolates on HeLa cervical cells. The cytotoxicity assay doubling time were done using direct counting method, while DNA staining was acrydine orange. isolate # 30 showed...
COVID-19 is associated with disseminated lung damage in patients, Dexamethasone can reduce injury caused by inflammation and there the progression to respiratory failure prevent death. This systematic review aimed determine benefits safety of treatment. The study was performed a comprehensive literature search which were published several databases i.e., PubMed, Science Direct, VHL Regional Portal, ClinicalTrials.gov within time 28 November 2020. Inclusion criteria articles on patients who...