A5015882195- Pain Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Pain Management and Placebo Effect
- Advanced Drug Delivery Systems
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Histone Deacetylase Inhibitors Research
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Stress Responses and Cortisol
- Pesticide Exposure and Toxicity
- HIV/AIDS drug development and treatment
- Intensive Care Unit Cognitive Disorders
- HIV Research and Treatment
- Toxic Organic Pollutants Impact
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Neonatal and fetal brain pathology
- Hemoglobin structure and function
- Anesthesia and Neurotoxicity Research
- Musculoskeletal pain and rehabilitation
- Mitochondrial Function and Pathology
Institute of Nuclear Medicine & Allied Sciences
2018-2025
Currently, the concept of lipid-based drug delivery systems has gained much interest because their capability to deliver drugs which dissolve sparingly in water or insoluble nature. Several methods exist, and each method its own advantages as well limitations. The primary objective formulation development is improve bioavailability drug. nano-sized have enough potential do so. This article addresses various barriers transportation through certain routes also common excipients used develop...
Ketamine is known for its antinociceptive effect and also used treatment-resistant depression. However, the efficacy safety of (2R, 6R)-hydroxynorketamine (HNK), a ketamine metabolite has been sparingly investigated acute pain management. The current study aims at investigating intranasal 6R)-HNK using pre-clinical models pain. Additionally, behavioural neurophysiological analyses were carried out effective time window. Antinociceptive was evaluated hot plate test Hargreaves' plantar test....
Subanesthetic ketamine has been used for treatment-resistant depression and is popular as an opioid-sparing agent.The present study aimed to investigate the dose-dependent antinociceptive effect of intranasal (INK) along with behavioral neurophysiological safety in mice.Antinociceptive efficacy was evaluated terms thermal nociceptive response formalin test. The studies were carried out separately healthy mice using telemetry-based cortical electroencephalography, hemodynamic changes,...
The study aimed to investigate the significance of serum biomarkers in severity grading traumatic brain injury (TBI). For this purpose, mice underwent fluid percussion (FPI) at three discrete levels, mild, moderate, and severe. trauma was verified by qualitative quantitative histopathology brain. samples were analyzed for potential changes ubiquitin C‑terminal hydrolase‑1 (UCHL‑1), S100β, interleukin‑6 (IL‑6), corticosterone, β‑endorphin 24 72 h post injury. A multifold increase values...