A5065971777- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Fuel Cells and Related Materials
- Cardiac electrophysiology and arrhythmias
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Obesity and Health Practices
- Cancer-related gene regulation
- Mechanical Circulatory Support Devices
- Metalloenzymes and iron-sulfur proteins
- High voltage insulation and dielectric phenomena
- Aerodynamics and Fluid Dynamics Research
- Congenital heart defects research
- Metabolism and Genetic Disorders
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- Thermal Analysis in Power Transmission
- Porphyrin Metabolism and Disorders
- Genomics and Chromatin Dynamics
Michigan Medicine
2024
University of Michigan
2018-2022
Trinity University
2020
Hospital Universitario Doctor Peset
2020
University of California, Los Angeles
2016
Morelia Institute of Technology
2015
UCLA Health
2015
Abstract Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive molecular processes underlying cardiac pumping. Physiological rates of myocardial consumption require heart resynthesize its entire pool several times per minute. In failing heart, cardiomyocyte metabolic dysfunction leads a reduction in capacity for synthesis and associated free cellular processes. Yet it remains unclear if how metabolic/energetic that occurs during failure...
Expression of a cohort disease-associated genes, some which are active in fetal myocardium, is considered hallmark transcriptional change cardiac hypertrophy models. How this transcriptome remodeling affected by the common genetic variation present populations unknown. We examined role genetics, as well contributions chromatin proteins, to regulate gene expression and heart failure susceptibility. 84 genetically distinct inbred strains control isoproterenol-treated mice, exhibited varying...
This paper details a multi-scale model computational of myocardial energetics---oxidative ATP synthesis, hydrolysis, and phosphate metabolite kinetics---and mechanics used to analyze data from rat cardiac decompensation failure. Combined, these two models simulate mechano-energetics: the coupling between metabolic production hydrolysis generate mechanical work. The is predict how differences in energetic state found failing versus control hearts causally contribute systolic dysfunction heart...
The adult mammalian heart has limited regenerative capacity following injury, leading to progressive failure and mortality. Recent studies have identified the spiny mouse (
Re-expression of fetal genes is a hallmark transcriptome change in models cardiac hypertrophy, but how this remodeling affected by the common genetic variation present populations unknown. We examined gene expression 86 strains control and isoproterenol (ISO)-treated mice, which exhibited varying degrees disease. Correlations between individual (Anf, Serca2a, alpha-MHC, beta-MHC) hypertrophic phenotypes were not significant. Expanded analysis 37 showed sparse correlation (at p<0.05) with...
Hydrolysis of ATP provides the chemical free energy to drive molecular processes underlying cardiac pumping. Under normal conditions heart hydrolyzes and resynthesizes entire pool several times per minute. In failing heart, cardiomyocyte metabolic dysfunction leads a reduction in potential (free hydrolysis) at which is synthesized made available cellular processes. We hypothesize that this metabolic/energetic causes contractile myocardium failure, contributing whole‐body phenotype (venous...
Abstract BACKGROUND New echocardiographic phenotypes of heart failure (HF) are focused on myocardial systolic involvement the left ventricle (LV), either endocardial and/or transmural. PURPOSE. To study pattern in patients (p) with HF preserved ventricular ejection fraction (pLVEF) and cardiac amyloidosis (CA). METHODS. Comparative 16 p CA pLVEF, considering as cut point LVEF &gt; 50%, NYHA class ≥ II / IV, a control group healthy people. Longitudinal Strain (LS) Circumferential (CS)...
The Rieske protein plays a key role in both cellular respiration and photosynthesis, transferring electrons through the respective cytochrome bc 1 b 6 f complexes of each process. It is characterized by [2Fe‐2S] cluster unique that one iron ligated nitrogens from two solvent‐exposed histidine residues while other sulfurs cysteines. In electron transport chain (ETC), oxidizes ubiquinol reduces c , between II IV. Previous work has demonstrated how hydrogen bonds, solvent accessibility ligands,...