A5053102199- Gut microbiota and health
- Pressure Ulcer Prevention and Management
- Diagnosis and Treatment of Venous Diseases
- Effects of Radiation Exposure
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Respiratory viral infections research
- Food Allergy and Anaphylaxis Research
- Microscopic Colitis
- Carcinogens and Genotoxicity Assessment
- Allergic Rhinitis and Sensitization
- Transgenic Plants and Applications
- Cancer Research and Treatments
- Oral health in cancer treatment
- Viral Infections and Outbreaks Research
- Clinical practice guidelines implementation
- Social and Demographic Issues in Germany
- Esophageal Cancer Research and Treatment
- Psychiatric care and mental health services
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Influenza Virus Research Studies
- DNA Repair Mechanisms
- Asthma and respiratory diseases
University of California, Los Angeles
2016-2024
Medical University of Vienna
2021-2024
Faculty (United Kingdom)
2020
Institute of Biological Chemistry, Academia Sinica
2020
Austrian Economics Center
2020
University of Vienna
2006-2013
Cedars-Sinai Medical Center
2013
University of California, Riverside
2013
University of Duisburg-Essen
2008-2012
Essen University Hospital
2005-2010
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver Knowledge Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology,...
Abstract Ataxia-telangiectasia is a genetic disorder associated with high incidence of B-cell lymphoma. Using an ataxia-telangiectasia mouse model, we compared lymphoma in several isogenic colonies harboring different bacterial communities, finding that intestinal microbiota are major contributor to disease penetrance and latency, lifespan, molecular oxidative stress, systemic leukocyte genotoxicity. High-throughput sequence analysis rRNA genes identified mucosa-associated phylotypes were...
Heat treatment of milk induces a reaction between the proteins and lactose, resulting in lactosylated protein species. The lactosylation two major whey α-lactalbumin β-lactoglobulin was investigated by reversed phase liquid chromatography−mass spectrometry (LC-MS). Three sample series, consisting aqueous model solutions each separately mixture whole milk, were heated for different time periods, progression monitored. observed degrees kinetics showed that not influenced presence other...
An optical immunochip biosensor has been developed as a rapid method for allergen detection in complex food matrixes, and its application evaluated the of egg white allergens, ovalbumin ovomucoid. The near-field phenomenon underlying basic principle sensor design is called resonance-enhanced absorption (REA), which utilizes gold nanoparticles (Au NPs) signal transducers highly sensitive interferometric setup. Using this approach, novel, simple, colorimetric solid-phase immunoassay on planar...
The purpose of this study was: (1) to determine the combination risk factors which best predicts developing pressure ulcers among inpatients in an acute care university hospital; (2) appropriate weight for each factor; and (3) derive a concise easy-to-use assessment tool daily use by nursing staff.Efficient application preventive measures against requires identification patients at risk. Adequate tools are still needed because predictive value existing is sometimes unsatisfactory.Survey.A...
The absolute quantitation of proteins in biological matrixes is great interest many fields and can be accomplished by different methodologies. Here, a method for the whey protein β-lactoglobulin using liquid chromatography coupled to mass spectrometry reported. developed approach was characterized detail applied determination contents various milk products. A special focus placed on recovery rates isolation procedure robust LC−MS. For these purposes internal standards were employed. observed...
Using the National Statistics ('DRG-Statistik') published by Federal Statistical Office, we analyzed prevalences of pressure ulcers coded as principal or additional diagnosis separately and describe differences in ulcer characteristics.Age-adjusted prevalence tables for gender age distribution diagnoses were provided Office.In 2005, about 16 million patients treated full-time German hospitals. 9,941 (0.06%) referred with 191,040 (1.19%) had at least one ulcer. People >65 years highest risk...
Ionizing space radiation causes oxidative DNA damage and triggers stress responses, compromised repair mechanisms can lead to increased risk of carcinogenesis. Young adult mice with developed innate adaptive immune systems that harbored either a conventional intestinal microbiota (CM) or an restricted microbial composition (RM) were irradiated total dose 1 Gy delivered by high-energy protons (2.5 GeV/n, LET = 0.2-2 keV/μm) silicon iron ions (850 MeV/n, ≈ 50 keV/μm 150 keV/μm, respectively)....
To compare point and period prevalence rates.Descriptive, cohort, cross-sectional survey.From a cohort of 25,075 cases, information on pressure ulcer status admission was recorded for 20,283 cases. From 3237 selected the team made 2234 assessments.Point prevalence, incidence rates.The showed rate 1.4% an 0.6%. Patients with were older, more likely to have had surgery, longer hospital stays, higher cost weight. The survey revealed 5.3%. within lengths stay, presented weight in comparison...
We analysed the effect of different body features on contact area, interface pressure and distribution three mattresses. Thirty-eight volunteers (age ranged from 17 to 73 years, 23 females) were asked lie mattresses in a random order: I, standard hospital foam mattresses; II, higher specification (Viscorelax Sure®); III, constant low devices (CareMedx®, AirSystems). Measurements performed supine position 90° left- right-sided position, respectively, using full-body mat (pressure mapping...
Intestinal microbiota play a significant role in nutrient metabolism, modulation of the immune system, obesity, and possibly carcinogenesis, although underlying mechanisms resulting disease or impacts on longevity caused by different intestinal are mostly unknown. Herein we use isogenic Atm-deficient wild type mice as models to interrogate changes metabolic profiles urine feces these mice, which differing their microbiota. Using high resolution mass spectrometry approach show that...
In a previous paper (Wilson and Maier, 1939) evidence was brought to show that the administration of sulphanilamide twice daily in dosage bordering on toxic limit guinea-pigs infected seven weeks previously with virulent strain Br. abortus able bring about sterilization tissues after treatment for three five weeks.The total used corresponded an average 0.8 mg. per gramme body weight.Animals given half this still remained two four weeks' treatment.These results receive confirmation from work,...
Glycan-targeting antibodies and pseudo-antibodies have been extensively studied for their stoichiometry, avidity, interactions with the rapidly modifying glycan shield of influenza A. Broadly neutralizing antiviral agents bind in same order when they neutralize enveloped viruses regardless location epitopes to host receptor binding site. Herein, we investigated cyanovirin-N (CV–N) surface-expressed glycoproteins such as those human immunodeficiency virus (HIV) gp120, hemagglutinin (HA),...
Aim. To evaluate the relation between pressure ulcers and delivery of care. Background. No decrease ulcer rates could be recognised in acute hospital care, despite intensive efforts prevention. Furthermore, reports show increasing rates. Design. Retrospective analysis data. Methods. The study included all inpatients from year 1 (2003/2004) 4 (2006/2007) interdisciplinary decubitus project. Information on was recorded at admission, discharge case new events. We analysed effect age, length...
Intestinal microbiota affect cell responses to ionizing radiation at the molecular level and can be linked development of immune system, controlled death or apoptosis. We have developed a mouse model report here that high-linear energy transfer (LET) induced repair chromosomal DNA lesions more efficiently in conventional than restricted intestinal mice. Based on different phylotype densities after whole-body irradiation, bacterial indicator phylotypes were found abundant microbiota....
Pressure ulcer is a relevant issue for quality management and cost containment of hospitals. Cross-sectional studies are the typical design to estimate frequency pressure ulcers. The derived point prevalence rate not as good case related reference value period rate. interdisciplinary project at University Clinics in Essen combined routine documentation with cross-sectional survey, thus providing both measurements first time.The computer-based collection information about ulcers started March...
Replicative senescence of human fibroblasts in vitro has been used as a model for vivo aging. The onset replicative varies between several months to years. A colony formation assay, critically dependent on growth speed, can be performed within weeks, and reported being an indicator the senescence. Earlier we could not find correlation speed mass cultures fibroblast strains. Therefore, studied assay 23 strains that varied widely their capacity. Neither number nor size colonies was related...
1. Experiments were carried out during the years 1931–5 in which mice on a basal diet of raw milk and white-flour biscuit compared with similar except that was replaced by commercially holderpasteurized (145–150° F. for 30 min.) belonging to same batch. Each group comprised aggregate about 1100 animals, usually 4–6 weeks old at commencement observation. For reasons given p. 206 no attempt made standardize volume consumed individual mice. Except preliminary experiments, when excess, amount...
Intestinal microbiota are considered a sensor for molecular pathways, which orchestrate energy balance, immune responses, and cell regeneration. We previously reported that restriction promoted higher levels of systemic radiation-induced genotoxicity, proliferative lymphocyte activation, apoptotic polarization metabolic pathways. Restricted intestinal (RM) harbors increased abundance Lactobacillus johnsonii (LBJ) has been investigated bacterial communities correlated genotoxicity. Indicator...