A5066529528- Malaria Research and Control
- Mosquito-borne diseases and control
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Hemoglobinopathies and Related Disorders
Howard University
2023-2024
Hypoglycemia, defined as a blood glucose < 2.2 mmol/L, is associated with death in pediatric cerebral malaria (CM). The optimal duration of monitoring CM unknown. We collected data from 1,674 hospitalized Malawian children to evaluate the association between hypoglycemia and or neurologic disability survivors. assessed routine periodic measurements glucose. Children at admission had 2.87-fold higher odds (95% CI: 1.35-6.09) and, if they survived, 3.21-fold greater 1.51-6.86) sequelae...
Abstract Background In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker associated death. The usefulness of post-admission measurements in CM is less clear. strength association between neurological sequelae survivors, well the optimal duration to identify at higher risk adverse outcomes unknown. Methods A retrospective cohort study 1674 Malawian hospitalized from 2000 2018 who had every 6...
Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those low mortality or neurologic morbidity, limiting power detect significant differences between intervention arms. One solution is enrichment, enrolling trial participants higher adverse We assessed if demographic, physical examination and point-of-care laboratory testing results in combination could...
Abstract Background Admission blood lactate has previously guided therapy and is a valid estimator of prognosis in children with cerebral malaria (CM). Since bolus intravenous fluid administration to febrile coma signs hypovolemia (including high lactate) may be harmful, the use guide waned. Its utility as prognostic biomarker, either at admission or during hospitalization, remains unclear. Methods We performed retrospective cohort study 1674 Malawian CM hospitalized from 2000–2018 who had...