A5016021645- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Extracellular vesicles in disease
- Biochemical Analysis and Sensing Techniques
- Obstructive Sleep Apnea Research
- Periodontal Regeneration and Treatments
- Ear and Head Tumors
- Phonetics and Phonology Research
- Neuroscience of respiration and sleep
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Olfactory and Sensory Function Studies
- Multisensory perception and integration
- Sinusitis and nasal conditions
- Regulation of Appetite and Obesity
- RNA and protein synthesis mechanisms
- Cerebral Venous Sinus Thrombosis
- Reconstructive Facial Surgery Techniques
- Neuroscience and Music Perception
- Meningioma and schwannoma management
- Noise Effects and Management
- Bone and Dental Protein Studies
- Tracheal and airway disorders
Ljubljana University Medical Centre
2016-2025
University of Ljubljana
2016-2025
Klinički Bolnički Centar Rijeka
2022
Medical University of Graz
2022
Faculty (United Kingdom)
2021
Campus Bio Medico University Hospital
2015
Usher syndrome (USH), the most prevalent cause of hereditary deafness–blindness, is an autosomal recessive and genetically heterogeneous disorder. Three clinical subtypes (USH1–3) are distinguishable based on severity sensorineural hearing impairment, presence or absence vestibular dysfunction, age onset retinitis pigmentosa. A total 10 causal genes, 6 for USH1, 3 USH2, 1 USH3, USH2 modifier gene, have been identified. robust molecular diagnosis required not only to improve genetic...
Functional and structural brain alterations in the absence of auditory input have been described, but observed changes deaf are not uniform. Some previous researchers focused only on areas, while others investigated whole or other selected regions interest. Majority studies revealed decreased white matter (WM) volume altered WM microstructure preserved grey (GM) structure areas deaf. However, increased GM also reported. Several were found outside these differ between studies. The differences...
To determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical standard conservative therapies.Patients were randomly allocated treatment with PVRP (PVRP group) or methods (control in a setting four once-monthly checkups subsequent follow-up. The outcome was measured Chronic Otitis Media Questionnaire-12 (COMQ-12), CPTBCI focus surface area, symptom-free time...
Choanal atresia is the most common congenital anatomical abnormality of nasal cavities, manifested with a clinical picture neonatal respiratory distress. The treatment requires interdisciplinary management based mainly on tertiary referral centre experiences. However, there lack high-quality evidence in available literature. Recommendations were prepared systematic review supporting literature: website survey addressed to participating authors consisting 28 questions and five live meetings....
The present study searched for evidence of possible associations between some genetic factors that could affect the development molar–incisor hypomineralisation (MIH). In 113 patients who were surgically treated at an Otorhinolaryngology and Cervicofacial Surgery Clinic (ORL) during early childhood, human leukocyte antigen (HLA) DQ2 DQ8 haplotypes single nucleotide polymorphisms (SNP) eight amelogenesis-related genes in genomic DNA. Genotypes determined by high resolution melting (HRM),...
Objectives: Pupil dilation can serve as a measure of auditory attention. It has been proposed an objective for adjusting hearing aid configurations, and threshold in the pediatric population. Here we explore (1) whether pupillary response (PDR) to audible sounds be reliably measured normally infants within their average attention span, adults, (2) how accurate within-participant models are classifying PDR based on stimulus type at various intensity levels, (3) amount analyzed data affects...
Abstract Objective Relationship between obesity and the taste is complex with many inconsistent conflicting findings that are largely methodology dependent. The impact of glucagon-like peptide-1 analogues on remains unaddressed. Research Design Methods In this 16-week, single-blinded, placebo-controlled study, 30 women polycystic ovary syndrome (PCOS), aged 33.7 ± 6.1 years a body mass index 36.4 4.4 kg/m2 were randomized to semaglutide 1.0 mg QW or placebo. Change in recognition was...
Objectives: This study aimed to investigate the impact of platelet-rich plasma (PRP) and gel (PRG) on tympanic membrane closure rates, hearing improvement, quality life following tympanoplasty. Methods: Seventy-two patients with chronic perforations were enrolled in a double-blinded, randomized controlled trial at single tertiary referral center. All underwent tympanoplasty using temporalis fascia graft randomly assigned one two groups: group received standard alone, while other...
Objective: To assess the influence of acquired auditory control on some voice parameters in deaf children and adults after cochlear implantation. Study Design: Prospective clinical study. Setting: Tertiary referral center. Patients: Twenty-nine prelingually deafened 11 postlingually adults. Interventions: The samples a vowel /a/ were analyzed with an Multi-Dimensional Voice Program (Kay Elemetrics Corporation, Lincoln Park, NJ) before 6 to 12 months Main Outcome Measures: average fundamental...
In order to prepare optimal platelet and extracellular vesicle (EV)-rich plasma for the treatment of chronic temporal bone inflammation, we studied effects centrifugation parameters on redistribution blood constituents in samples 23 patients 20 volunteers with no record disease. Concentrations cells EVs were measured by flow cytometry. Sample content was inspected scanning electron microscopy. A mathematical model constructed interpret experimental results. The observed enrichment platelets...
Objective: To assess the influence of acquired auditory control on some voice parameters in deaf children and adults after cochlear implantation. Study Design: Prospective clinical study. Setting: Tertiary referral center. Patients: Twenty-nine prelingually deafened 11 postlingually adults. Interventions: The samples a vowel /a/ were analyzed with an Multi-Dimensional Voice Program (Kay Elemetrics Corporation, Lincoln Park, NJ) before 6 to 12 months Main Outcome Measures: average fundamental...
Purpose: to determine a detailed clinical and haplotypic variability of the Slovenian USH2A patients with homozygous c.11864G>A (p.Trp3955Ter) nonsense mutation develop sensitive, accurate rapid screening test. Methods: Ten unrelated ophthalmological exam were included in our study. The High-Resolution Melting (HRM) method was developed for fast reliable detection mutation. Results: represents vast majority pathogenic alleles USH2A-Usher syndrome population (84%). median age onset...
USH2A mutation is the most common cause of retinitis pigmentosa, with or without hearing impairment. Patients commonly exhibit hyperautofluorescent ring on fundus autofluorescence imaging (FAF) and rod-cone dystrophy electrophysiology. A detailed study three patients a rare pattern double rings was performed. Twenty-four typical single were used for comparison ages onset, visual fields, optical coherence tomography, electrophysiology, audiograms. Double delineated area pericentral retinal...