A5052752998- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Crystallization and Solubility Studies
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- Gastrointestinal motility and disorders
- Analytical Methods in Pharmaceuticals
- Gastroesophageal reflux and treatments
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Diet and metabolism studies
- Protein purification and stability
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- HIV/AIDS Research and Interventions
- Probiotics and Fermented Foods
- Pharmacogenetics and Drug Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Microscopic Colitis
- Transgenic Plants and Applications
- Hepatitis B Virus Studies
KU Leuven
2016-2025
Utrecht University
1987
It was the purpose of this study to investigate excipient-mediated precipitation inhibition upon induction supersaturation poorly water-soluble drugs in aspirated human intestinal fluids (HIF) representing both fasted and fed state. Etravirine, ritonavir, loviride, danazol fenofibrate were selected as model compounds. For comparative purposes, also evaluated simple aqueous buffer, simulation media representative for state (FaSSIF FeSSIF, respectively). Supersaturation induced test containing...
The availability of in vitro tools that are constructed on the basis a detailed knowledge key aspects gastrointestinal (GI) physiology and their impact formulation performance subsequent drug release behaviour is fundamental to success efficiency oral product development. Over last six years, development optimization improved, biorelevant has been cornerstone IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together industry academic partners, by linking tool human studies...
The aim of this study was to evaluate gastrointestinal (GI) dissolution, supersaturation, and precipitation posaconazole, formulated as an acidified (pH 1.6) neutral 7.1) suspension. A physiologically based pharmacokinetic (PBPK) modeling simulation tool applied simulate GI systemic concentration-time profiles which were directly compared with intraluminal data measured in humans. Advanced Dissolution Absorption Metabolism (ADAM) model the Simcyp Simulator correctly simulated incomplete...