A5042272526- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
- Dental Radiography and Imaging
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- Orthopaedic implants and arthroplasty
- Temporomandibular Joint Disorders
- Facial Trauma and Fracture Management
- Orthodontics and Dentofacial Orthopedics
- Cancer Immunotherapy and Biomarkers
- Hernia repair and management
- Dental materials and restorations
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Esophageal and GI Pathology
- Advanced X-ray and CT Imaging
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Oral and Maxillofacial Pathology
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
China Medical University
2010-2024
China Medical University Hospital
2010-2024
University of Southern California
2019-2024
Atrium Health Wake Forest Baptist
2005-2024
Washington University in St. Louis
2013-2024
Western University of Health Sciences
2024
Wake Forest University
2003-2022
Illinois College
2022
University of Illinois Chicago
2022
Buddhist Tzu Chi General Hospital
2021
Abstract Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by antagonizing adenosine receptors. Chronic caffeine use results in an adaptation of the vascular receptor system presumably to compensate for vasoconstrictive effects caffeine. We investigated on blood flow (CBF) increasing levels chronic use. Low (mean = 45 mg/day), moderate 405 and high 950 mg/day) users underwent quantitative perfusion magnetic resonance imaging four separate occasions:...
Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory milieu all impact DCs with regard to promoting or inhibiting tumor immunity. The following review introduces important facets function, how subset phenotype can affect interplay other factors microenvironment. It will also discuss current cancer...
Abstract The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise several subsites. We investigated survival rates and clinical pathological characteristics different anatomical subsites Taiwanese population. retrospectively analyzed data for 3010 patients with treated at Changhua Christian Hospital. Subsequently, we compared features Pathological T4 stage OSCCs occurred alveolar...
Tantalum (Ta) oxides and their coatings have been proved to increase applications in the biomedical fields by improving osseointegration wear resistance. In this study, Ta oxide containing different proportions of Ag are deposited on SS304 materials. A twin-gun magnetron sputtering system is used deposit tantalum oxide-Ag coating. Staphylococcus aureus, which exhibits physiological commensalism human skin, nares, mucosal oral areas, chosen as model for vitro antibacterial analyses via a...
Abstract Objectives: Three‐dimensional finite element (FE) models of splinted prosthetic crowns were studied and stress analyses evaluated with different types implant support, including standard, wide or two implant(s) for partial, posterior edentulous restorations. Material methods: The FE constructed based on a cadaver mandible containing the 2nd premolar 1st molar. these teeth modeled as connected disconnected to mimic non‐splinted designs, respectively. One standard was placed at...
This study compared the adequacy of dental cone beam computed tomography (CBCT) and micro (micro-CT) in evaluating structural parameters trabecular bones. The cellular synthetic bones 4 density groups (Groups 1–4: 0.12, 0.16, 0.20, 0.32 g/cm3) were used this study. Each group comprised 8 experimental specimens that approximately 1 cm3. Dental CBCT micro-CT scans conducted on each specimen to obtain independent measurements following bone parameters: volume fraction (BV/TV), specific surface...
Abstract Background Dental cone beam computed tomography (CBCT) is commonly used to evaluate cancellous bone density before dental implant surgery. However, our knowledge, no measurement approach has been standardized yet. This study aimed the relationship between three different regions of interest (ROI) methods on at site using CBCT images. Methods Patients’ images ( n = 300) obtained surgery were processed Mimics (Materialise, Leuven, Belgium). At potential sites, rectangle, cylinder, and...
Bone stress and interfacial sliding at the bone-implant interface (BII) were analyzed in zirconia titanium implants with various thread designs conditions (bonded BII contact BIIs different frictional coefficients) for both conventional immediately loaded treatments.A total of 18 finite element models comprising two implant materials (zirconia titanium), three (different shapes pitches), BIIs) to assess effects on bone stresses BII. The material properties model anisotropic, a lateral force...
Recent studies indicate that umbilical cord stem cells are cytoprotective against several disorders. One critical limitation in using is reduction their viability under stressful conditions, such as diabetes. However, the molecular intricacies responsible for diabetic conditions not fully elucidated. In this study, we found high glucose (HG) induced loss of chaperone homeostasis, stabilized PTEN, triggered downstream signaling cascade, and apoptosis oxidative stress Wharton's jelly derived...
Before extracting impacted lower third molars, dentists must first identify the spatial relationship between inferior alveolar nerve (IAN) and an molar to prevent injury from extraction. Nevertheless, current method for describing IAN is deficient. Therefore, objectives of this study were to: (1) evaluate relative position molars IAN; (2) investigate by using a cylindrical coordinate system. From radiology department's database, we selected computed tomography images 137 (from 75 patients)...
This study compared the capabilities of dual-energy X-ray absorptiometry (DXA) and dental cone-beam computed tomography (CBCT) for predicting cortical bone strength rat femurs tibias.Specimens tibias obtained from 14 rats were first scanned with DXA to obtain areal mineral density (BMD) midshaft portion bones. The bones then using CBCT measure volumetric (vCtBMD) cross-sectional moment inertia (CSMI) calculating index (BSI). A three-point bending test was conducted fracture load each femur...
Trismus is frequently a sequel of temporomandibular joint (TMJ) involvement in zygomaticomaxillary complex (ZMC) fracture. Although trismus commonly observed patients with ZMC fracture, continuous follow-up examinations their degree mouth opening have rarely been documented. The aim this retrospective study was to determine the incidence and clinical significance fracture involving glenoid fossa or articular eminence TMJ an emphasis on trismus. medical computed tomography (CT) imaging data...
ABSTRACT PURPOSE Cancer neoantigens are important targets of cancer immunotherapy. Neoantigen vaccines have the potential to induce or enhance highly specific antitumor immune responses with minimal risk autoimmunity. We developed a neoantigen DNA vaccine platform capable efficiently presenting both HLA class I and II epitopes. To test safety, feasibility efficacy this platform, we performed phase 1 clinical trial in triple negative breast patients persistent disease following neoadjuvant...
Bone morphogenetic proteins (BMPs) have been shown to play a role in the functional maintenance of adult epididymis. To begin investigate BMP signal transduction during postnatal epididymal development, we examined expression profile Bmp7 murine epididymis by situ hybridization. Our data show that early development (younger than 3 wk age), transcripts are detected uniformly epithelial cells throughout As mice aged (from 4 wk), was gradually restricted initial segment, with increased levels....
The G protein alpha-subunit alpha 2 is essential to the developmental program of Dictyostelium. transiently phosphorylated on a serine residue(s) following stimulation with extracellular cAMP (Gundersen, R. E., and Devreotes, P.N. (1990) Science 248, 591-593). To aid in defining function phosphorylation, we identified site phosphorylation. Comparison isoelectric points (pI) nonphosphorylated forms indicated that single mole phosphate added 2. Cleavage at tryptophan residues...