A5009831581- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Botanical Research and Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Lipid Membrane Structure and Behavior
- Sphingolipid Metabolism and Signaling
- Microbial Natural Products and Biosynthesis
- Asymmetric Synthesis and Catalysis
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
- Digestive system and related health
- Marine Sponges and Natural Products
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Estrogen and related hormone effects
- Plant and animal studies
- Piperaceae Chemical and Biological Studies
Ludwig-Maximilians-Universität München
2016-2019
McGill University
2013-2018
Walter and Eliza Hall Institute of Medical Research
2015
The University of Melbourne
2015
Abstract Two amino acids play a key role in the first total synthesis of lycopalhine A. l ‐glutamic acid serves as convenient chiral starting material for 13‐step synthesis, and ‐proline promotes an unusual 5‐ endo ‐trig Mannich cyclization that generates central pyrrolidine ring Lycopodium alkaloid. The bicyclo[3.3.0]octanol moiety molecule is formed through intramolecular aldol addition may occur spontaneously nature.
Distant relative: The configuration of the quaternary stereocenter in puraquinonic acid (see scheme, right) is defined by groups far removed from point asymmetry. use a bicyclic thioglycolate lactam to set at an early stage cuts length synthesis natural product nearly two thirds.
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress understanding how ceramides execute their biological roles is hampered by a lack methods to manipulate cellular levels metabolic fate with appropriate spatiotemporal precision. Here, we report on clickable, azobenzene-containing ceramides, caCers, photoswitchable substrates exert optical control over production cells. Combining atomic force...
Activation of the Wnt/β-catenin pathway occurs in a vast majority colorectal cancers. However, outcome disease strongly varies from patient to patient, even within same tumor stage. This heterogeneity is governed large parts by genetic makeup individual tumors and combination oncogenic mutations. To express throughout intestinal epithelium degradation resistant β-catenin (Ctnnb1) which lacks first 131 amino acids, we inserted an epitope-tagged ΔN(1-131)-β-catenin encoding cDNA as knockin...
A concise route to the azatricyclo[6.2.1.04,11]undecane core of (−)-dendrobine and (−)-mubironine C is described wherein an unstabilized azomethine ylide cycloaddition provides complete carbon framework natural products. The cyclization precursor made in short order from (R)-carvone through unconventional high-pressure Ireland–Claisen reaction. Attempts install a final hydroxyl group intramolecular lactonization strategy observation unexpected highly complex enal–ene product are also reported.
Über die Distanz: Purachinonsäure (rechts im Schema) enthält ein Stereozentrum, dessen Konfiguration von weit entfernten Gruppen definiert wird. Die Verwendung eines bicyclischen Thioglycolatlactams zur frühen Einführung des quartären Stereozentrums reduziert Länge der Naturstoffsynthese um fast zwei Drittel.
Abstract Two amino acids play a key role in the first total synthesis of lycopalhine A. l ‐glutamic acid serves as convenient chiral starting material for 13‐step synthesis, and ‐proline promotes an unusual 5‐ endo ‐trig Mannich cyclization that generates central pyrrolidine ring Lycopodium alkaloid. The bicyclo[3.3.0]octanol moiety molecule is formed through intramolecular aldol addition may occur spontaneously nature.
Abstract Two amino acids play a key role in the total synthesis of lycopalhine A (I).