A5087225320- Spanish Linguistics and Language Studies
- Higher Education Teaching and Evaluation
- Literacy and Educational Practices
- Linguistic Studies and Language Acquisition
- Inflammatory mediators and NSAID effects
- Dementia and Cognitive Impairment Research
- Educational Technology in Learning
- Nursing care and research
- Historical Linguistics and Language Studies
- Sesquiterpenes and Asteraceae Studies
- Machine Learning in Healthcare
- Marine Sponges and Natural Products
- Geography and Education Methods
- Educational theories and practices
- Cultural and political discourse analysis
- Technology Use by Older Adults
- Synthesis and Biological Activity
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sulfur-Based Synthesis Techniques
- Diet and metabolism studies
- Aging, Health, and Disability
- Oxidative Organic Chemistry Reactions
- Dental materials and restorations
- Second Language Learning and Teaching
- Immigration and Intercultural Education
Yale University
2024
Universidad Cardenal Herrera CEU
2018-2023
Universidad de Granada
2015-2018
Universidad del Desarrollo
2016
Universitat de València
2007-2010
University of Salerno
2007
As a part of our drug discovery effort, recently we clarified the molecular basis phospholipase A2 (PLA2) inactivation by petrosaspongiolide M (PM), an interesting metabolite belonging to marine sesterterpene family, containing in its structural architecture γ-hydroxybutenolide moiety and showing potent anti-inflammatory activity. In attempt expand diversity as well simplify crucial synthetic features parent compound, decided develop selected library based on densely functionalized scaffold....
Purpose: The early detection of Mild Cognitive Impairment (MCI) is essential in aging societies where dementia becoming a common manifestation among the elderly. Thus our aim to develop decision tree discriminate individuals at risk MCI non-institutionalized elderly users community pharmacy. A more clinically and patient-oriented role pharmacist primary care makes dispensation medication an adequate situation for effective, rapid, easy, reproducible screening MCI. Methods: cross-sectional...
Rheumatic diseases result in chronic pain (CP) and require treatment with drugs whose prolonged administration is associated side effects. However, publications the academic literature have suggested that diet modification food supplementation can play a crucial role alleviating symptoms of inflammatory disease. Thus, it hoped use an anti-inflammatory for management might improved quality life. Hence, here we aimed to investigate effect foods patients CP caused by rheumatic diseases.After...
El objetivo de este estudio piloto es analizar el efecto una intervención emocional y/o farmacoterapéutica en cuidadores informales personas con deterioro cognitivo sobre sus niveles sobrecarga, su salud percibida, bloqueos para un desarrollo saludable y consumo fármacos. Para ello, 21 (edad media = 67.10 ± 3.80 años) fueron asignados a uno cuatro grupos: control, emocional, seguimiento farmacoterapéutico, e farmacoterapéutico. programa tuvo duración nueve semanas. Los resultados mostraron...
A peptide-catalyzed enantioselective oxidation of sulfides to yield pharmaceutically relevant chiral sulfoxides is reported. Experimental evidence suggesting that a hydrogen bond-donating moiety must be present in the substrate achieve high levels enantioinduction supported by computational modeling transition states. These models also indicate dual points contact between peptidic catalyst and are likely responsible for formation one desired sulfoxide 94:6 er.
In our recent studies, we focused attention on the synthesis of several γ‐hydroxybutenolides designed basis petrosaspongiolide M 1 (PM) structure that has been recognized to potently inhibit inflammatory process through selective PLA 2 enzyme inhibition. By means a combination computational methods and efficient synthetic strategies, generated small collections PM modified analogs identify new potent inhibitors, suitable for clinical development. course biological screening compounds,...
Subjective memory complaints (SMCs) may be important markers in the prediction of cognitive deterioration. The aim this study was to find associations between individual lifestyle factors, which contribute impairment (CI) people with SMCs and conduct a literature review on relationship internet use CI subjects over 50 years old, as related factor. This case-controlled that included 497 aged who were recruited from 19 community pharmacies. Three screening tests used detect possible CIs,...
Mild cognitive impairment (MCI) is the first sign of dementia among elderly populations and its early detection crucial in our aging societies. Common MCI tests are time-consuming such that indiscriminate massive screening would not be cost-effective. Here, we describe a protocol uses machine learning techniques to rapidly select candidates for further via question-based test. This minimizes number resources required because only patients who potentially positive tested further. methodology...
Mild cognitive impairment (MCI) is the first sign of dementia among elderly populations and its early detection crucial in our aging societies. Common MCI tests are time-consuming such that indiscriminate massive screening would not be cost-effective. Here, we describe a protocol uses machine learning techniques to rapidly select candidates for further via question-based test. This minimizes number resources required because only patients who potentially positive tested further. methodology...
Evaluación de la Pérdida Osea y del Éxito / Fracaso